INT54835

Context Info Confidence 0.59 First Reported 1994 Last Reported 2010 Negated 2 Speculated 1 Reported most in Abstract Documents 5 Total Number 6 Disease Relevance 2.08 Pain Relevance 1.07

extracellular space (Col2a1) extracellular region (Col2a1) cytoplasm (Col2a1)

Anatomy Link Frequency cartilage 2 Col2a1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Osteoarthritis 78 98.92 Snapping jaw 2 94.68 cINOD 3 89.64 dexamethasone 2 87.32 Pain 6 86.96 Arthritis 8 86.32 diclofenac 2 83.60 aspirin 2 83.12 Inflammation 23 73.24 cytokine 10 70.32

Disease Link Frequency Relevance Heat Osteoarthritis 77 98.92 Chondrosarcoma 6 97.84 Osteoporosis 2 97.76 Metabolic Bone Disease 1 97.00 Temporomandibular Joint Syndrome 2 94.68 INFLAMMATION 27 89.40 Pain 4 86.96 Arthritis 15 86.32 Rheumatoid Arthritis 2 77.72 Immune System Diseases 1 68.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The presence of type-II collagen is obviously not regulated only by compressive forces but probably also by tension loading.

Neg (not) Regulation (regulated) of type-II collagen

1) Confidence 0.59 Published 1996 Journal Eur J Orthod Section Abstract Doc Link 8746172 Disease Relevance 0.17 Pain Relevance 0.17

We show that the combination of chondrosarcoma cultures, type II collagen specific ELISA and dimethylmethylene blue dye binding assay serves as a useful model for screening the effects of agents capable of modulating type II collagen and glycosaminoglycan synthesis.

Regulation (modulating) of type II collagen associated with chondrosarcoma

2) Confidence 0.39 Published 1994 Journal Agents Actions Section Abstract Doc Link 7942329 Disease Relevance 0.23 Pain Relevance 0.13

The effects of antiarthritic agents on type II collagen and glycosaminoglycan synthesis were examined in rat chondrosarcoma cultures.

Regulation (effects) of type II collagen associated with chondrosarcoma

3) Confidence 0.39 Published 1994 Journal Agents Actions Section Abstract Doc Link 7942329 Disease Relevance 0.35 Pain Relevance 0.19

No collagen II imunostaining was detected in control G1 group of rats 15 and 30 days after surgery and only a faint positive staining was observed on day 45 (Fig. 3a, d and g), although there was fibrous tissue throughout the healing process.

Regulation (detected) of collagen II

4) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923611 Disease Relevance 0.10 Pain Relevance 0

Glucosamine alone had no observable stimulatory effect on the transcription of primary cartilage matrix genes, such as aggrecan, collagen type II, or genes involved in glycosaminoglycan synthesis; however, glucosamine proved to be a potent, broad-spectrum inhibitor of IL-1?.

Neg (no) Spec (observable) Regulation (effect) of collagen type II in cartilage

5) Confidence 0.08 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1794517 Disease Relevance 0.07 Pain Relevance 0.11

Further studies are necessary to confirm the efficacy of COLLII as a protective factor of OA cartilage, and the potential significance of uCTX-I as a further marker to assess the evolution of EOA bone damage.

Regulation (efficacy) of COLLII in cartilage associated with osteoarthritis

6) Confidence 0.02 Published 2008 Journal J Orthop Traumatol Section Body Doc Link PMC2656961 Disease Relevance 1.15 Pain Relevance 0.48

General Comments

This test has worked.