INT55002

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Context Info
Confidence 0.64
First Reported 1994
Last Reported 2010
Negated 3
Speculated 3
Reported most in Body
Documents 46
Total Number 49
Disease Relevance 22.80
Pain Relevance 3.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ASAP1) cytoplasm (ASAP1)
Anatomy Link Frequency
plasma 3
bladder 3
pulmonary artery 3
alveolar macrophages 2
pancreas 2
ASAP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 21 99.96 Very High Very High Very High
Catecholamine 99 99.84 Very High Very High Very High
interstitial cystitis 24 99.72 Very High Very High Very High
Inflammation 179 97.44 Very High Very High Very High
cva 61 91.28 High High
fibrosis 79 89.88 High High
Dopamine 88 86.60 High High
adenocard 22 72.16 Quite High
Pain 5 65.08 Quite High
imagery 30 62.28 Quite High
Disease Link Frequency Relevance Heat
Pulmonary Alveolar Proteinosis 309 100.00 Very High Very High Very High
Pancreatitis 19 100.00 Very High Very High Very High
Cervical Intraepithelial Neoplasia 38 99.96 Very High Very High Very High
Peripheral Arterial Disease 76 99.92 Very High Very High Very High
Cervical Cancer 217 99.84 Very High Very High Very High
Infection 115 99.76 Very High Very High Very High
Interstitial Cystitis 24 99.72 Very High Very High Very High
Tricuspid Valve Insufficiency 106 99.58 Very High Very High Very High
Cancer 148 99.52 Very High Very High Very High
Pulmonary Hypertension 392 99.26 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High expression of DDEF1 was shown to result in more motile low-grade UM cells by Ehlers et al. [63] and could therefore be important in metastatic development [63, 114, 115].
Gene_expression (expression) of DDEF1 associated with melanoma
1) Confidence 0.64 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902045 Disease Relevance 1.02 Pain Relevance 0
HPV DNA testing has been shown to have, on average, a 25% greater sensitivity than Pap cytology but somewhat lower specificity (on average, 10% lower) for detecting CIN 2/3 or cancer.
Gene_expression (detecting) of Pap associated with papillomavirus infection, cancer and cervical intraepithelial neoplasia
2) Confidence 0.61 Published 2004 Journal BMC Womens Health Section Body Doc Link PMC2096700 Disease Relevance 0.93 Pain Relevance 0
One woman who last had a Pap test 14 years ago noted,
Gene_expression (test) of Pap
3) Confidence 0.59 Published 2007 Journal Prev Chronic Dis Section Body Doc Link PMC2099293 Disease Relevance 0.39 Pain Relevance 0.07
Reason for having had a Pap test
Gene_expression (test) of Pap
4) Confidence 0.58 Published 2008 Journal Prev Chronic Dis Section Body Doc Link PMC2578779 Disease Relevance 0 Pain Relevance 0
Adjusted odds of ever having had a Pap test
Gene_expression (test) of Pap
5) Confidence 0.58 Published 2008 Journal Prev Chronic Dis Section Body Doc Link PMC2578779 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: Urinary HIP/PAP levels were significantly higher in IC patients and the apparent HIP/PAP expression in the bladder urothelium was more frequently observed among IC patients.
Gene_expression (expression) of PAP in bladder
6) Confidence 0.57 Published 2010 Journal Urology Section Body Doc Link 19646740 Disease Relevance 0.06 Pain Relevance 0
We have previously shown that PAP III is expressed with increased frequency in the bladder urothelium in a rat cystitis model (Takahara Y, et al.
Gene_expression (expressed) of PAP in bladder associated with cystitis
7) Confidence 0.57 Published 2010 Journal Urology Section Abstract Doc Link 19646740 Disease Relevance 0.62 Pain Relevance 0.35
METHODS: HIP/PAP levels in the urine from patients with IC were measured by enzyme-linked immunosorbent assay, and HIP/PAP expression in the bladder tissues was assessed by immunohistochemical study.
Gene_expression (expression) of PAP in urine
8) Confidence 0.57 Published 2010 Journal Urology Section Body Doc Link 19646740 Disease Relevance 0.09 Pain Relevance 0
OBJECTIVES: To investigate the pathophysiology of interstitial cystitis (IC), we examined urinary levels and urothelial expression of human orthologue of pancreatitis-associated protein (PAP) III, namely, hepatocarcinoma-intestine-pancreas (HIP)/PAP, in patients with IC.
Spec (examined) Gene_expression (expression) of PAP in pancreas associated with pancreatitis and interstitial cystitis
9) Confidence 0.57 Published 2010 Journal Urology Section Abstract Doc Link 19646740 Disease Relevance 0.55 Pain Relevance 0.37
Only 11% treat the infection and repeat Pap smear and 24% treat infection and do not repeat Pap smear.[8]
Gene_expression (smear) of Pap associated with infection
10) Confidence 0.55 Published 2010 Journal CytoJournal Section Body Doc Link PMC2926920 Disease Relevance 1.47 Pain Relevance 0.17
SULT1B1 and 1C2 cluster together in the trees of local structure, activity, and binding in the presence of PAP.
Gene_expression (presence) of PAP
11) Confidence 0.55 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1847840 Disease Relevance 0 Pain Relevance 0.16
The binding site for PAP or PAPS (PAP(S)) is nearly identical in all structures bound to these ligands, with highly conserved residues contributing to the binding pocket (highlighted in red in Figures 2 and 3).
Gene_expression (site) of PAP
12) Confidence 0.55 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1847840 Disease Relevance 0 Pain Relevance 0
Cofactor (PAP/PAPS) binding residues were also mapped onto the alignment and excluded from all pairwise comparisons and similarity calculations.
Gene_expression (residues) of PAP
13) Confidence 0.55 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1847840 Disease Relevance 0 Pain Relevance 0
Although we did not measure inhibition by this compound, we note that SULT1A1 bound DCNP in the presence of PAP, whereas SULT1A3 did not (Table 1).
Gene_expression (presence) of PAP
14) Confidence 0.55 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1847840 Disease Relevance 0 Pain Relevance 0.23
The evidence for the efficacy of Pap smear screening in cervical cancer comes mainly from three sources: (i) epidemiologic studies reporting a risk of invasive cervical cancer 2–10 times greater among women who have not been screened and an increased risk with time since last normal smear or with lower frequency of screening; (ii) cervical cancer incidence and mortality rates, which decreased sharply following the introduction of cytology screening in Scandinavian countries, Canada and the United States, and did so in proportion to the intensity of the screening efforts; and (iii) multiple national and international consensus panels worldwide.[31]
Gene_expression (screening) of Pap associated with cervical cancer
15) Confidence 0.53 Published 2004 Journal BMC Womens Health Section Body Doc Link PMC2096700 Disease Relevance 0.81 Pain Relevance 0
Estimation of relevant degrees of RVED or PAP reduction can possibly be derived indirectly from human thrombolysis studies, since thrombolytic treatment was associated with reduced mortality (4.7% vs 11.1%) in the setting of right ventricular dilatation in acute pulmonary embolism [21].
Gene_expression (reduction) of PAP associated with pulmonary embolism and cva
16) Confidence 0.52 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2859373 Disease Relevance 0.41 Pain Relevance 0.17
CONCLUSIONS: Urinary HIP/PAP levels were significantly higher in IC patients and the apparent HIP/PAP expression in the bladder urothelium was more frequently observed among IC patients.
Gene_expression (levels) of PAP in bladder
17) Confidence 0.49 Published 2010 Journal Urology Section Body Doc Link 19646740 Disease Relevance 0.07 Pain Relevance 0
The progress of the reaction was monitored by reading the absorbance at 259 nm, and the amount of PAP produced was determined by integration of the resolved peaks using the HPLC software (Waters, http://www.waters.com/).
Gene_expression (produced) of PAP
18) Confidence 0.49 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1847840 Disease Relevance 0 Pain Relevance 0
For example, both SULT1C3 and SULT1B1 were stabilized by catecholamines in the absence of PAP, but neither showed significant activity toward this class of compounds.
Neg (absence) Gene_expression (absence) of PAP associated with catecholamine
19) Confidence 0.49 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1847840 Disease Relevance 0 Pain Relevance 0.08
Interestingly, binding of SULT1C1, 1B1, and 1E1 to resveratrol was only observed in the absence of PAP, but all are active toward this substrate.
Neg (absence) Gene_expression (absence) of PAP
20) Confidence 0.49 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1847840 Disease Relevance 0 Pain Relevance 0.03

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