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Context Info
Confidence 0.15
First Reported 1992
Last Reported 1992
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.43
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Oprd1, Crh) extracellular space (Crh) extracellular region (Crh)
plasma membrane (Oprd1) response to stress (Crh) signal transducer activity (Oprd1)
Anatomy Link Frequency
hypothalamus 1
Oprd1 (Rattus norvegicus)
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 1 100.00 Very High Very High Very High
narcan 1 96.88 Very High Very High Very High
Endogenous opioid 1 63.24 Quite High
Disease Link Frequency Relevance Heat
Hypoglycemia 5 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that 1) central administration of EP acts through the opioid receptor to inhibit hypoglycemia-induced CRF gene expression in the hypothalamus and CRF release, which results in a decrease in ACTH secretion and POMC mRNA levels in the AP; and 2) the active site of EP is the CRF neuron in the paraventricular nucleus.
opioid receptor Negative_regulation (inhibit) of CRF in hypothalamus associated with hypoglycemia and opioid receptor
1) Confidence 0.15 Published 1992 Journal Endocrinology Section Abstract Doc Link 1311237 Disease Relevance 0.43 Pain Relevance 0.16

General Comments

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