INT55353

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Context Info
Confidence 0.57
First Reported 1994
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 0.31
Pain Relevance 5.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cofactor metabolic process (Ppt1) Golgi apparatus (Ppt1) cytosol (Ppt1)
extracellular space (Ppt1) protein modification process (Ppt1) extracellular region (Ppt1)
Anatomy Link Frequency
striatum 5
infraspinatus 2
nucleus accumbens 1
Ppt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 18 100.00 Very High Very High Very High
Paracetamol 7 100.00 Very High Very High Very High
narcan 2 99.84 Very High Very High Very High
Nucleus accumbens 6 99.76 Very High Very High Very High
antagonist 9 99.74 Very High Very High Very High
Dopamine 41 99.52 Very High Very High Very High
Dynorphin 15 97.36 Very High Very High Very High
aspirin 7 95.44 Very High Very High Very High
Antinociceptive 3 85.52 High High
Enkephalin 16 77.44 Quite High
Disease Link Frequency Relevance Heat
Myofascial Pain Syndromes 3 75.00 Quite High
Pain 5 73.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The decrease in PPT-A mRNA levels induced by the neonatal DA lesion was not changed after SR46349B treatment in the posterior part of the lesioned striatum.
Negative_regulation (decrease) of Positive_regulation (induced) of PPT in striatum associated with dopamine
1) Confidence 0.57 Published 2002 Journal J. Neurosci. Res. Section Abstract Doc Link 11754083 Disease Relevance 0 Pain Relevance 0.49
The present results demonstrate that knife-cut transections of the frontal corticostriatal pathway are capable of reversing the increased striatal PPE mRNA levels, but not the decreased PPT mRNA levels, induced by a 6-OHDA lesion of the dopaminergic input.
Neg (not) Negative_regulation (decreased) of Neg (not) Positive_regulation (induced) of PPT mRNA
2) Confidence 0.42 Published 1994 Journal Eur. J. Neurosci. Section Abstract Doc Link 7981878 Disease Relevance 0 Pain Relevance 0.34
Lesions of the dopaminergic striatal afferents resulted in marked increases in the mRNA encoding PPE throughout the striatum, including the ventral striatum and nucleus accumbens, while the levels of PPT mRNA were considerably reduced in these structures.
Negative_regulation (reduced) of Positive_regulation (levels) of PPT mRNA in striatum associated with nucleus accumbens
3) Confidence 0.41 Published 1994 Journal Eur. J. Neurosci. Section Abstract Doc Link 7981878 Disease Relevance 0 Pain Relevance 0.28
The ultrasound test group demonstrated statistically significant increases in PPT seg (decreased infraspinatus sensitivity) at 1, 3 and 5 min, when compared with PPT seg in the sham ultrasound group.
Negative_regulation (decreased) of Positive_regulation (increases) of PPT in infraspinatus
4) Confidence 0.31 Published 2008 Journal Pain Section Abstract Doc Link 18508198 Disease Relevance 0.31 Pain Relevance 0.54
The concurrent administration of the D1 DA antagonist, SCH-23390, blocked the GBR-induced increases in SP, NKA and PPT mRNA but failed to affect DYN or PD mRNA levels; the concurrent administration of the D2 DA antagonist, spiperone, blocked the GBR-induced increases in SP, NKA and PPT mRNA and also DYN and PD mRNA.
Negative_regulation (blocked) of Positive_regulation (increases) of PPT associated with dopamine, antagonist and substance p
5) Confidence 0.24 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8717356 Disease Relevance 0 Pain Relevance 0.78
The concurrent administration of the D1 DA antagonist, SCH-23390, blocked the GBR-induced increases in SP, NKA and PPT mRNA but failed to affect DYN or PD mRNA levels; the concurrent administration of the D2 DA antagonist, spiperone, blocked the GBR-induced increases in SP, NKA and PPT mRNA and also DYN and PD mRNA.
Negative_regulation (blocked) of Positive_regulation (increases) of PPT associated with dopamine, antagonist and substance p
6) Confidence 0.24 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8717356 Disease Relevance 0 Pain Relevance 0.71
The increase in PPT resulting from 3 microM acetaminophen was reduced by naloxone and apamin but not changed by L-nitro-arginine methylester (L-NAME), its inactive enantiomer D-NAME, acetylsalicylic acid, methysergide, or tropisetron.
Negative_regulation (reduced) of Positive_regulation (increase) of PPT associated with aspirin, paracetamol and narcan
7) Confidence 0.23 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 15616065 Disease Relevance 0 Pain Relevance 1.21
Dopaminergic denervation with 6-hydroxydopamine (6OHDA) blocked the GBR-induced increases in SP and DYN and PPT and PD mRNAs.
Negative_regulation (blocked) of Positive_regulation (increases) of PPT associated with substance p
8) Confidence 0.21 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8717356 Disease Relevance 0 Pain Relevance 0.74
Lesions of the dopaminergic striatal afferents resulted in marked increases in the mRNA encoding PPE throughout the striatum, including the ventral striatum and nucleus accumbens, while the levels of PPT mRNA were considerably reduced in these structures.
Negative_regulation (reduced) of in nucleus accumbens Positive_regulation (levels) of PPT mRNA in striatum associated with nucleus accumbens
9) Confidence 0.14 Published 1994 Journal Eur. J. Neurosci. Section Abstract Doc Link 7981878 Disease Relevance 0 Pain Relevance 0.28

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