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Context Info
Confidence 0.23
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.51
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Hpse) extracellular region (Hpse) cell adhesion (Hpse)
nucleus (Hpse) carbohydrate metabolic process (Hpse) lysosome (Hpse)
Anatomy Link Frequency
pituitary 2
Hpse (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 11 99.68 Very High Very High Very High
Intracerebroventricular 9 99.48 Very High Very High Very High
Multiple sclerosis 26 94.80 High High
opioid receptor 2 91.92 High High
antagonist 4 90.64 High High
depression 1 66.32 Quite High
Inflammation 37 40.28 Quite Low
cytokine 4 25.84 Quite Low
Central nervous system 11 25.00 Low Low
agonist 6 25.00 Low Low
Disease Link Frequency Relevance Heat
Sprains And Strains 2 99.68 Very High Very High Very High
Stress 174 99.44 Very High Very High Very High
Disease 23 99.24 Very High Very High Very High
Multiple Sclerosis 132 99.04 Very High Very High Very High
Endometriosis (extended) 11 91.96 High High
Cushing's Syndrome /


2 81.92 Quite High
Depression 1 66.32 Quite High
Apoptosis 2 44.08 Quite Low
INFLAMMATION 40 40.28 Quite Low
Neuroblastoma 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acute administration of morphine stimulates the secretion of hypothalamic-pituitary-adrenal (HPA) hormones, ACTH, beta-endorphin and corticosterone in the rat.
Localization (secretion) of HPA in pituitary associated with morphine
1) Confidence 0.23 Published 1999 Journal J. Endocrinol. Section Abstract Doc Link 10556776 Disease Relevance 0.16 Pain Relevance 0.41
HPA response to restraint stress
Localization (response) of HPA associated with stress
2) Confidence 0.21 Published 2010 Journal Brain Research Section Body Doc Link PMC2994639 Disease Relevance 0.86 Pain Relevance 0
In our earlier studies we have demonstrated that recombinant human interferon-alpha 2A (rHu-IFN-alpha 2A) inhibits hypothalamo-pituitary-adrenocortical (HPA) secretion following both peripheral and central administration.
Localization (secretion) of HPA in pituitary
3) Confidence 0.14 Published 1994 Journal Brain Behav. Immun. Section Abstract Doc Link 8003770 Disease Relevance 0 Pain Relevance 0.16
In rhesus monkeys, the HPA axis response to a 30-min intracerebroventricular infusion of interleukin-1?
Localization (response) of HPA associated with intracerebroventricular
4) Confidence 0.12 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2890612 Disease Relevance 0.35 Pain Relevance 0.05
An adequate HPA response is necessary for correct control of disease; in fact, rat strains with a blunted HPA response are more vulnerable to EAE.
Localization (response) of HPA associated with multiple sclerosis, sprains and strains and disease
5) Confidence 0.11 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2958904 Disease Relevance 1.99 Pain Relevance 0.27

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