INT55647

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Context Info
Confidence 0.35
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 5.43
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Nfasc) plasma membrane (Nfasc)
Anatomy Link Frequency
skull 1
peripheral nervous system 1
Nfasc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
imagery 12 99.36 Very High Very High Very High
Pain 6 96.24 Very High Very High Very High
Peripheral nervous system 3 95.50 Very High Very High Very High
sodium channel 72 92.60 High High
Action potential 25 91.88 High High
Inflammation 11 81.20 Quite High
anesthesia 3 73.12 Quite High
potassium channel 14 30.48 Quite Low
Nav1.6 2 28.48 Quite Low
Nav1.2 92 28.04 Quite Low
Disease Link Frequency Relevance Heat
Skin Infection 74 100.00 Very High Very High Very High
Adhesions 7 99.62 Very High Very High Very High
Osteomyelitis 9 99.32 Very High Very High Very High
Wound Healing 3 97.88 Very High Very High Very High
Pain 5 96.24 Very High Very High Very High
Infection 15 94.04 High High
Amputation 1 88.36 High High
Staphylococcus Infection 9 87.76 High High
Pressure And Volume Under Development 12 87.48 High High
Injury 26 86.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is important to recognize that NF may occur spontaneously, and it should be suspected in patients with unexplained soft tissue pain and tenderness.
NF Binding (recognize) of associated with pain and skin infection
1) Confidence 0.35 Published 1994 Journal Am Surg Section Abstract Doc Link 8010562 Disease Relevance 1.76 Pain Relevance 0.16
NF associated with underlying osteomyelitis is extremely uncommon with only one previous case report of scalp necrotising fasciitis with aspergillus osteomyelitis of the skull [8].
NF Binding (associated) of in skull associated with osteomyelitis and skin infection
2) Confidence 0.07 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2442594 Disease Relevance 1.29 Pain Relevance 0.08
Cell adhesion molecules such as neurofascin-186 bind ankyrinG and become AIS-targeted via an intracellular FIGQY motif [82], [83], [84], so in theory adding this sequence to ChR2-YFP could localise it to the AIS without interfering with sodium channel binding sites.
neurofascin-186 Binding (bind) of associated with sodium channel and adhesions
3) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2966437 Disease Relevance 0.23 Pain Relevance 0.09
NF exhibits high signal intensity on T2-weighted images by MRI with hyperintense signal corresponding to fluids associated with NF.
NF Binding (associated) of associated with skin infection and imagery
4) Confidence 0.03 Published 2008 Journal Cases J Section Body Doc Link PMC2577109 Disease Relevance 1.96 Pain Relevance 0.43
In the nodes of the peripheral nervous system (PNS), the aggregation of axonal components is dependent on ankyrin G, but the priming event is initiated by gliomedin, a membrane protein positioned in the microvilli of the Schwann cell facing the node of Ranvier, via a direct interaction with the extracellular domain of neurofascin-186 and neuronal cell adhesion molecule (Eshed et al., 2005, 2007; Dzhashiashvili et al., 2007).
neurofascin-186 Binding (interaction) of in peripheral nervous system associated with peripheral nervous system and adhesions
5) Confidence 0.01 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2600743 Disease Relevance 0.19 Pain Relevance 0.17

General Comments

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