INT55647

Context Info Confidence 0.35 First Reported 1994 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 5.43 Pain Relevance 0.94

cell adhesion (Nfasc) plasma membrane (Nfasc)

Anatomy Link Frequency skull 1 peripheral nervous system 1 Nfasc (Rattus norvegicus)

Pain Link Frequency Relevance Heat imagery 12 99.36 Pain 6 96.24 Peripheral nervous system 3 95.50 sodium channel 72 92.60 Action potential 25 91.88 Inflammation 11 81.20 anesthesia 3 73.12 potassium channel 14 30.48 Nav1.6 2 28.48 Nav1.2 92 28.04

Disease Link Frequency Relevance Heat Skin Infection 74 100.00 Adhesions 7 99.62 Osteomyelitis 9 99.32 Wound Healing 3 97.88 Pain 5 96.24 Infection 15 94.04 Amputation 1 88.36 Staphylococcus Infection 9 87.76 Pressure And Volume Under Development 12 87.48 Injury 26 86.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It is important to recognize that NF may occur spontaneously, and it should be suspected in patients with unexplained soft tissue pain and tenderness.

NF Binding (recognize) of associated with pain and skin infection

1) Confidence 0.35 Published 1994 Journal Am Surg Section Abstract Doc Link 8010562 Disease Relevance 1.76 Pain Relevance 0.16

NF associated with underlying osteomyelitis is extremely uncommon with only one previous case report of scalp necrotising fasciitis with aspergillus osteomyelitis of the skull [8].

NF Binding (associated) of in skull associated with osteomyelitis and skin infection

2) Confidence 0.07 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2442594 Disease Relevance 1.29 Pain Relevance 0.08

Cell adhesion molecules such as neurofascin-186 bind ankyrinG and become AIS-targeted via an intracellular FIGQY motif [82], [83], [84], so in theory adding this sequence to ChR2-YFP could localise it to the AIS without interfering with sodium channel binding sites.

neurofascin-186 Binding (bind) of associated with sodium channel and adhesions

3) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2966437 Disease Relevance 0.23 Pain Relevance 0.09

NF exhibits high signal intensity on T2-weighted images by MRI with hyperintense signal corresponding to fluids associated with NF.

NF Binding (associated) of associated with skin infection and imagery

4) Confidence 0.03 Published 2008 Journal Cases J Section Body Doc Link PMC2577109 Disease Relevance 1.96 Pain Relevance 0.43

In the nodes of the peripheral nervous system (PNS), the aggregation of axonal components is dependent on ankyrin G, but the priming event is initiated by gliomedin, a membrane protein positioned in the microvilli of the Schwann cell facing the node of Ranvier, via a direct interaction with the extracellular domain of neurofascin-186 and neuronal cell adhesion molecule (Eshed et al., 2005, 2007; Dzhashiashvili et al., 2007).

neurofascin-186 Binding (interaction) of in peripheral nervous system associated with peripheral nervous system and adhesions

5) Confidence 0.01 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2600743 Disease Relevance 0.19 Pain Relevance 0.17

General Comments

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