INT55655

From wiki-pain
Revision as of 01:26, 21 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 19
Disease Relevance 7.98
Pain Relevance 5.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (DCN) aging (DCN) extracellular region (DCN)
proteinaceous extracellular matrix (DCN)
Anatomy Link Frequency
smooth muscle 2
blood 1
endothelial cells 1
brain 1
spleen 1
DCN (Homo sapiens)
Pain Link Frequency Relevance Heat
interstitial cystitis 5 98.82 Very High Very High Very High
Paracetamol 87 98.78 Very High Very High Very High
Inflammation 25 96.04 Very High Very High Very High
Analgesic 6 93.04 High High
Pain 102 90.56 High High
withdrawal 90 89.84 High High
metalloproteinase 46 88.72 High High
Calcitonin gene-related peptide 9 87.92 High High
c fibre 3 85.12 High High
algogenic 3 82.24 Quite High
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 680 99.76 Very High Very High Very High
Hereditary Corneal Dystrophies 2 99.48 Very High Very High Very High
Interstitial Cystitis 5 98.82 Very High Very High Very High
Penetrating Wounds 1 96.68 Very High Very High Very High
Calcification 10 96.08 Very High Very High Very High
INFLAMMATION 25 96.04 Very High Very High Very High
Syndrome 5 94.28 High High
Hyperplasia 9 92.20 High High
Cancer 104 91.76 High High
Pain 106 90.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, suitable dosages of LLLI may result in more effective tissue healing by promoting type I collagen and decorin synthesis.
Gene_expression (synthesis) of decorin
1) Confidence 0.75 Published 2009 Journal J. Orthop. Res. Section Abstract Doc Link 18991342 Disease Relevance 0.11 Pain Relevance 0.08
Cell proliferation and mRNA expressions of type I collagen and decorin were then measured.
Gene_expression (expressions) of decorin
2) Confidence 0.75 Published 2009 Journal J. Orthop. Res. Section Abstract Doc Link 18991342 Disease Relevance 0.16 Pain Relevance 0.12
The mRNA expressions of decorin and type I collagen in fibroblasts with LLLI were significantly higher (p < 0.05).
Gene_expression (expressions) of decorin in fibroblasts
3) Confidence 0.75 Published 2009 Journal J. Orthop. Res. Section Abstract Doc Link 18991342 Disease Relevance 0.12 Pain Relevance 0.09
Quantitative differences in IC tissues versus normal bladder tissue with respect to gene expression for this proteoglycan core protein can now be determined.
Gene_expression (expression) of proteoglycan core protein in bladder associated with interstitial cystitis
4) Confidence 0.50 Published 1994 Journal World J Urol Section Abstract Doc Link 8012411 Disease Relevance 0.40 Pain Relevance 0.34
Left branch shows distinctive underexpression and loss of expression areas with genes such as IFNGR2, interleukin 2, laminin B1, MSH2, MSH6 CASP8 and 10, RB1, PCNA, EGFR and PGS2, among others, and a few overexpressed genes such as MIF, CDK 2, 5, and 7, RPSA, JUP and ITGAE.
Gene_expression (expression) of PGS2
5) Confidence 0.46 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.56 Pain Relevance 0.03
Increases in decorin expression are associated with capillary endothelial cells in a model of angiogenesis and in inflamed arterial walls [22,23].
Gene_expression (expression) of decorin in endothelial cells
6) Confidence 0.37 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.41 Pain Relevance 0.03
Increased expression of decorin may lead to a reduction in the TGF-?
Gene_expression (expression) of decorin
7) Confidence 0.37 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.50 Pain Relevance 0
However, an increase in decorin expression in smooth muscle may also contribute to IPAH since over expression of decorin in arterial smooth muscle cells promotes the contraction of type I collagen and enhance arterial calcification [25,26].
Gene_expression (expression) of decorin in smooth muscle associated with calcification and pulmonary hypertension
8) Confidence 0.37 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.39 Pain Relevance 0.12
CHED can be confused with other congenital causes of corneal opacification, such as CSCD and Peters anomaly.
Gene_expression (confused) of CSCD
9) Confidence 0.37 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2695576 Disease Relevance 0.72 Pain Relevance 0
is a major inducer of extracellular matrix synthesis and decreases the production of decorin [20].
Gene_expression (production) of decorin in extracellular matrix
10) Confidence 0.32 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.52 Pain Relevance 0
However, an increase in decorin expression in smooth muscle may also contribute to IPAH since over expression of decorin in arterial smooth muscle cells promotes the contraction of type I collagen and enhance arterial calcification [25,26].
Gene_expression (expression) of decorin in smooth muscle associated with calcification and pulmonary hypertension
11) Confidence 0.32 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.39 Pain Relevance 0.12
We observed an average 2.49 fold increase in TIMP-3 expression relative to the housekeeping G3PDH mRNA and a 2.55 fold increase in decorin expression (both P < 0.01).
Gene_expression (expression) of decorin
12) Confidence 0.29 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.46 Pain Relevance 0
Since the upregulated genes were identified from pooled patient samples we verified increased expression of TIMP-3 and DCN in individual IPAH patient samples by RNA blot for two genes (Fig. 1).
Gene_expression (expression) of DCN associated with pulmonary hypertension
13) Confidence 0.25 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.47 Pain Relevance 0
Decorin was identified as being differentially expressed in both our SSH and this microarray study.
Gene_expression (expressed) of Decorin
14) Confidence 0.25 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.86 Pain Relevance 0.25
Gu[12] reported a stimulatory effect in proteoglycan core protein gene expression of TGF-?
Gene_expression (expression) of proteoglycan core protein
15) Confidence 0.09 Published 2006 Journal J Orthop Surg Section Body Doc Link PMC1636034 Disease Relevance 0.26 Pain Relevance 0
Hinz et al. [9] showed acetaminophen inhibits COX-2 activity in human blood cells and suppresses PG E2 generation in human blood monocytes.
Gene_expression (generation) of PG E2 in blood associated with paracetamol
16) Confidence 0.03 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2908220 Disease Relevance 0.38 Pain Relevance 1.49
For example, Swierkosz et al. [15] showed the greatest reduction of PG E2 synthesis was in the lung followed by the spleen and brain.
Gene_expression (synthesis) of PG E2 in brain
17) Confidence 0.03 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2908220 Disease Relevance 0.45 Pain Relevance 1.65
For example, Swierkosz et al. [15] showed the greatest reduction of PG E2 synthesis was in the lung followed by the spleen and brain.
Gene_expression (synthesis) of PG E2 in spleen
18) Confidence 0.01 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2908220 Disease Relevance 0.45 Pain Relevance 1.65
There are a number of receptors (including a heparin sulphate receptor) expressed differentially on various cell types, which provide entry points for Herpes viruses [10].
Gene_expression (expressed) of sulphate receptor
19) Confidence 0.01 Published 2002 Journal BMC Complement Altern Med Section Body Doc Link PMC139995 Disease Relevance 0.37 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox