INT55859

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Context Info
Confidence 0.35
First Reported 1994
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 0
Pain Relevance 7.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dll1) cell-cell signaling (Dll1)
Anatomy Link Frequency
spinal cord 2
spinal 1
Dll1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 50 100.00 Very High Very High Very High
Enkephalin 35 100.00 Very High Very High Very High
medulla 6 100.00 Very High Very High Very High
Kappa opioid receptor 8 99.98 Very High Very High Very High
agonist 25 99.52 Very High Very High Very High
Spinal cord 6 99.00 Very High Very High Very High
antagonist 22 98.52 Very High Very High Very High
Opioid 2 98.34 Very High Very High Very High
antinociception 14 98.00 Very High Very High Very High
Delta opioid receptors 2 97.64 Very High Very High Very High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, delta2 opioid agonism appeared more consistent and reliable than delta1 opioid agonism in stimulating water intake when paired with AII, and these data indicate interactions between delta1 and delta2 agonists and AII in mediating water intake.
delta1 Binding (interactions) of associated with agonist and opioid
1) Confidence 0.35 Published 1997 Journal Peptides Section Abstract Doc Link 9149296 Disease Relevance 0 Pain Relevance 0.50
This study used isobolographic analysis to determine how delta1 and delta2 opioid receptors in the VMM interact with their respective receptors in the spinal cord to produce antinociception.
delta1 Binding (interact) of in spinal cord associated with antinociception, medulla, opioid receptor and spinal cord
2) Confidence 0.35 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10215679 Disease Relevance 0 Pain Relevance 1.24
MET-induced enhancement of H2O2 release was mediated via delta1 or delta2 opioid receptor subtypes, or by mu-kappa opioid receptor functional interactions, while MET-induced suppression involved functional interactions between delta1 and mu, delta2 and mu, or delta1 and kappa opioid receptors.
delta1 Binding (interactions) of associated with kappa opioid receptor, opioid receptor and enkephalin
3) Confidence 0.33 Published 2008 Journal Neuropeptides Section Abstract Doc Link 18237778 Disease Relevance 0 Pain Relevance 1.60
MET-induced enhancement of H2O2 release was mediated via delta1 or delta2 opioid receptor subtypes, or by mu-kappa opioid receptor functional interactions, while MET-induced suppression involved functional interactions between delta1 and mu, delta2 and mu, or delta1 and kappa opioid receptors.
delta1 Binding (interactions) of associated with kappa opioid receptor, opioid receptor and enkephalin
4) Confidence 0.33 Published 2008 Journal Neuropeptides Section Abstract Doc Link 18237778 Disease Relevance 0 Pain Relevance 1.61
Interaction between medullary and spinal delta1 and delta2 opioid receptors in the production of antinociception in the rat.
delta1 Binding (Interaction) of in spinal associated with antinociception, enkephalin and opioid receptor
5) Confidence 0.30 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 10215679 Disease Relevance 0 Pain Relevance 1.23
Delta antagonist and kappa agonist activity of Naltriben: evidence for differential kappa interaction with the delta 1 and delta 2 opioid receptor subtypes.
delta 1 Binding (interaction) of associated with antagonist, agonist and opioid receptor
6) Confidence 0.04 Published 1994 Journal Life Sci. Section Title Doc Link 8028443 Disease Relevance 0 Pain Relevance 0.69
They also suggest that nor-BNI-sensitive kappa opioid receptors interact with delta 2, but not delta 1 opioid receptors in the spinal cord.
delta 1 Neg (not) Binding (interact) of in spinal cord associated with kappa opioid receptor, opioid receptor and spinal cord
7) Confidence 0.02 Published 1994 Journal Life Sci. Section Abstract Doc Link 8028443 Disease Relevance 0 Pain Relevance 0.77

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