INT55894

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Context Info
Confidence 0.47
First Reported 1994
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.19
Pain Relevance 0.28

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signal transduction (Rasa1) cell adhesion (Rasa1) plasma membrane (Rasa1)
intracellular (Rasa1) embryo development (Rasa1) cytoplasm (Rasa1)
Rasa1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 2 99.94 Very High Very High Very High
Inflammation 2 99.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2 99.70 Very High Very High Very High
Colon Cancer 6 49.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our previous study, we demonstrated that azoxymethane (AOM) treatment significantly enhanced the expression of ras p21, the protein product of ras genes, and that the dietary administration of chemopreventive agents such as D,L-alpha-difluoromethylornithine (DFMO), a irreversible inhibitor of ornithine decarboxylase, and piroxicam, a non-steroidal anti-inflammatory drug (NSAID), exerted a significant inhibitory effect on AOM-induced ras p21 expression.
Positive_regulation (exerted) of Gene_expression (expression) of ras p21 associated with inflammation and cinod
1) Confidence 0.47 Published 1994 Journal Carcinogenesis Section Abstract Doc Link 8033306 Disease Relevance 0.10 Pain Relevance 0.15
In our previous study, we demonstrated that azoxymethane (AOM) treatment significantly enhanced the expression of ras p21, the protein product of ras genes, and that the dietary administration of chemopreventive agents such as D,L-alpha-difluoromethylornithine (DFMO), a irreversible inhibitor of ornithine decarboxylase, and piroxicam, a non-steroidal anti-inflammatory drug (NSAID), exerted a significant inhibitory effect on AOM-induced ras p21 expression.
Positive_regulation (enhanced) of Gene_expression (expression) of ras p21 associated with inflammation and cinod
2) Confidence 0.47 Published 1994 Journal Carcinogenesis Section Abstract Doc Link 8033306 Disease Relevance 0.09 Pain Relevance 0.14

General Comments

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