INT55957

From wiki-pain
Revision as of 01:10, 24 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 1993
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 57
Total Number 64
Disease Relevance 37.87
Pain Relevance 7.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (PRNP) endoplasmic reticulum (PRNP) nucleolus (PRNP)
plasma membrane (PRNP) nucleus (PRNP) cell cycle (PRNP)
Anatomy Link Frequency
PRP 5
body 4
brain 2
foot 2
blood 2
PRNP (Homo sapiens)
Pain Link Frequency Relevance Heat
iatrogenic 89 100.00 Very High Very High Very High
Serotonin 8 99.96 Very High Very High Very High
Pain 107 99.72 Very High Very High Very High
Inflammation 61 98.72 Very High Very High Very High
adenocard 3 98.50 Very High Very High Very High
headache 27 98.36 Very High Very High Very High
Central nervous system 51 97.72 Very High Very High Very High
c fibre 15 97.20 Very High Very High Very High
medulla 33 96.08 Very High Very High Very High
depression 10 95.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Creutzfeldt Jakob Disease 994 100.00 Very High Very High Very High
Disease 927 100.00 Very High Very High Very High
Targeted Disruption 482 100.00 Very High Very High Very High
Prion Diseases 288 100.00 Very High Very High Very High
Drug Induced Neurotoxicity 29 100.00 Very High Very High Very High
Kuru 505 99.74 Very High Very High Very High
Pain 106 99.72 Very High Very High Very High
Stress 66 99.06 Very High Very High Very High
Sprains And Strains 928 98.72 Very High Very High Very High
INFLAMMATION 57 98.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At peak of dobutamine stress test, systolic blood pressure, heart rate and PRP were increased similar to exercise test.
Positive_regulation (increased) of PRP in heart associated with stress
1) Confidence 0.67 Published 1993 Journal Kaku Igaku Section Abstract Doc Link 8345695 Disease Relevance 1.68 Pain Relevance 0.30
During subsequent exposure to activated PRP, the discharge commenced, on average, after a significant delay of about three minutes.
Positive_regulation (activated) of PRP in PRP
2) Confidence 0.67 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 8041482 Disease Relevance 0.19 Pain Relevance 0.87
In a first protocol, receptive fields of nociceptive C-fibers, at the corium side of the skin patch, were exposed to adenosine diphosphate (ADP), to heparinized human platelet-rich plasma (PRP) and to PRP activated by ADP.
Positive_regulation (activated) of PRP in PRP associated with nociception, c fibre and adenocard
3) Confidence 0.67 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 8041482 Disease Relevance 0.18 Pain Relevance 0.73
After application of activated PRP, 4/5 high threshold mechanosensitive C-units and 4/5 mechano-cold sensitive C-units became responsive to heat stimulation but only few of these fibers were excited (1/5 in each group).
Positive_regulation (activated) of PRP in PRP
4) Confidence 0.58 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 8041482 Disease Relevance 0.16 Pain Relevance 0.75
This lack of susceptibility of Tg(HuPrP) mice, together with the earlier pioneering work of Scott et al. [162], subsequently led Telling and colleagues to generate mice that expressed a chimeric PrP protein in which a segment of mouse PrPC was replaced with the corresponding human PrP sequence [161].
Positive_regulation (segment) of PrPC
5) Confidence 0.50 Published 2010 Journal Neuropathology and Applied Neurobiology Section Body Doc Link PMC3017745 Disease Relevance 1.12 Pain Relevance 0.04
While PrP expression is absolutely required for prion propagation and neurotoxicity [124] knockout of PrPC in embryonic models [139,140] or in adult brain [141] has no overt phenotypic effect that influences lifespan or fertility.
Positive_regulation (required) of PrPC in adult brain associated with targeted disruption, drug induced neurotoxicity and lifespan
6) Confidence 0.50 Published 2010 Journal Neuropathology and Applied Neurobiology Section Body Doc Link PMC3017745 Disease Relevance 0.62 Pain Relevance 0.09
METHODS: We compared two groups of patients undergoing panretinal photocoagulation (PRP) with an indirect laser.
Positive_regulation (undergoing) of PRP
7) Confidence 0.49 Published 2005 Journal Eye (Lond) Section Body Doc Link 15543180 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: When given in a single dose, oral diclofenac is an effective pretreatment analgesic agent for reducing the pain experienced during PRP for PDR.
Positive_regulation (experienced) of PRP
8) Confidence 0.49 Published 2009 Journal Ophthalmology Section Body Doc Link 19376588 Disease Relevance 0 Pain Relevance 0
We observed a fall of PRP serotonin in patients with tension-type headache to similar levels after treatment as the depressed group.
Positive_regulation (fall) of PRP in PRP associated with headache and serotonin
9) Confidence 0.49 Published 1993 Journal Cephalalgia Section Abstract Doc Link 8242728 Disease Relevance 0.89 Pain Relevance 1.17
It is proposed that PrPSc is the infectious agent acting to replicate itself with high fidelity by recruiting endogenous PrPC and that the difference between these isoforms lies purely in the monomer conformation and its state of aggregation [1–5,7–9].
Positive_regulation (recruiting) of PrPC
10) Confidence 0.47 Published 2010 Journal Neuropathology and Applied Neurobiology Section Body Doc Link PMC3017745 Disease Relevance 0.13 Pain Relevance 0
The oral transmissibility of BSE to humans to cause vCJD provides yet another link between kuru and BSE/vCJD.
Positive_regulation (cause) of vCJD associated with creutzfeldt jakob disease and kuru
11) Confidence 0.44 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2581654 Disease Relevance 1.62 Pain Relevance 0.16
In transgenic animals, a 106 amino acid fragment of the protein comprising PrP?
Positive_regulation (comprising) of PrP associated with targeted disruption
12) Confidence 0.44 Published 2010 Journal Neuropathology and Applied Neurobiology Section Body Doc Link PMC3017745 Disease Relevance 0.77 Pain Relevance 0
Figure 4 shows comparison of the typical PrP plaque pattern seen in the present kuru patient with cases of sCJD, iatrogenic CJD and vCJD.
Positive_regulation (iatrogenic) of CJD in plaque associated with iatrogenic, creutzfeldt jakob disease and kuru
13) Confidence 0.44 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2581659 Disease Relevance 0.64 Pain Relevance 0.20
However, there is now considerable evidence that different mutations may have different structural consequences in the expressed protein, including acting to destabilize the native PrPC fold, to increase aggregation propensity, to alter cellular trafficking, or to stabilize alternative protein (PrPSc) structures [175–180].
Positive_regulation (increase) of PrPC
14) Confidence 0.41 Published 2010 Journal Neuropathology and Applied Neurobiology Section Body Doc Link PMC3017745 Disease Relevance 0.73 Pain Relevance 0
However, there is now considerable evidence that different mutations may have different structural consequences in the expressed protein, including acting to destabilize the native PrPC fold, to increase aggregation propensity, to alter cellular trafficking, or to stabilize alternative protein (PrPSc) structures [175–180].
Positive_regulation (stabilize) of PrPC
15) Confidence 0.41 Published 2010 Journal Neuropathology and Applied Neurobiology Section Body Doc Link PMC3017745 Disease Relevance 0.80 Pain Relevance 0
Our research was the first to demonstrate transmission of BSE prions to transgenic mice expressing human PrP and these data confirmed that vCJD was caused by human exposure to the BSE prion strain [26,28] (Figure 3).
Positive_regulation (caused) of vCJD associated with targeted disruption, creutzfeldt jakob disease and sprains and strains
16) Confidence 0.41 Published 2010 Journal Neuropathology and Applied Neurobiology Section Body Doc Link PMC3017745 Disease Relevance 1.86 Pain Relevance 0.04
Because kuru, iatrogenic CJD and vCJD are caused by a peripheral route of exposure to infectious prions, it has been speculated that extensive lymphoreticular pathogenesis may result from this common route of exposure.
Positive_regulation (caused) of vCJD associated with iatrogenic, creutzfeldt jakob disease and kuru
17) Confidence 0.41 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2581659 Disease Relevance 1.29 Pain Relevance 0.09
PRP is promoted as an ideal autologous biological blood-derived product, which can be exogenously applied to various tissues where it releases high concentrations of platelet derived growth factors that enhance wound healing, bone healing and also tendon healing.
Positive_regulation (promoted) of PRP in tendon associated with wound healing
18) Confidence 0.40 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2861637 Disease Relevance 0.70 Pain Relevance 0.29
-TCP (Synthograft®, Bicon, Boston, MA, USA) mixed with 50 µl of the angiogenic factor-enriched PRP (activated PRP with the modified method + 2 × 106 PBMNCs) was implanted into the defect.
Positive_regulation (activated) of PRP
19) Confidence 0.35 Published 2010 Journal The Journal of Advanced Prosthodontics Section Body Doc Link PMC2984511 Disease Relevance 0.08 Pain Relevance 0.37
PBMNCs and PRP were collected by additional centrifugation (200 g and 1400 g, respectively) and PRP was activated with the method described above.
Positive_regulation (activated) of PRP
20) Confidence 0.35 Published 2010 Journal The Journal of Advanced Prosthodontics Section Body Doc Link PMC2984511 Disease Relevance 0.14 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox