INT55961

Context Info Confidence 0.68 First Reported 1994 Last Reported 2009 Negated 0 Speculated 1 Reported most in Body Documents 2 Total Number 9 Disease Relevance 9.39 Pain Relevance 0.92

mitochondrion (Maob) oxidoreductase activity (Maob)

Anatomy Link Frequency platelet 4 brainstem 1 Maob (Mus musculus)

Pain Link Frequency Relevance Heat medulla 2 99.06 Inflammation 8 97.88 cerebral cortex 1 97.28 monoamine 52 85.76 addiction 48 81.76 alcohol 8 81.32 Nicotine 16 80.80 anesthesia 1 74.56 Serotonin 24 49.36 antidepressant 8 14.48

Disease Link Frequency Relevance Heat Nicotine Addiction 1368 99.98 INFLAMMATION 8 97.88 Hyperammonemia 1 92.20 Cancer 24 90.12 Lung Cancer 24 86.60 Colon Cancer 8 82.24 Suicidal Behaviour 8 68.80 Cardiovascular Disorder Under Development 16 48.80 Atherosclerosis 24 5.00 Hypertension 16 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To investigate the persistent increase in MAO-B protein concentration, a study of the methylation of its gene promoter was undertaken in a small supplementary cohort of similar subjects.

Spec (investigate) Positive_regulation (increase) of MAO-B protein

1) Confidence 0.68 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2775922 Disease Relevance 1.55 Pain Relevance 0.10

This smoking-induced long-lasting effect was due to demethylation of the MAOB gene promoter which resulted in a persistent high protein concentration of platelet MAO-B.

Positive_regulation (concentration) of MAO-B in platelet associated with nicotine addiction

2) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 0.87 Pain Relevance 0

MAOA activities were decreased in cerebellum (by 23%, P < 0.05) and brainstem (by 16%, P < 0.05) of spf mice; activities of MAOB were concomitantly increased in cerebellum (by 22%, P < 0.05), brainstem (by 20%, P < 0.05) and cerebral cortex (by 22%, P < 0.05).

Positive_regulation (increased) of MAOB in brainstem associated with medulla and cerebral cortex

3) Confidence 0.60 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 8041507 Disease Relevance 0.09 Pain Relevance 0.38

Both S and FS exhibited reduced methylation of the MAOB promoter, leading to a more active transcription of the gene and hence a greater protein concentration of MAO-B.

Positive_regulation (methylation) of MAOB associated with nicotine addiction

4) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 1.15 Pain Relevance 0.19

This smoking-induced long-lasting effect was due to demethylation of the MAOB gene promoter which resulted in a persistent high protein concentration of platelet MAO-B.

Positive_regulation (induced) of MAOB in platelet associated with nicotine addiction

5) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 0.90 Pain Relevance 0

The persistence of increased protein concentrations of MAO-B was unexpected, even though some haematological and inflammation characteristics remain modified for several years after quitting smoking [19], [35], [36].

Positive_regulation (increased) of MAO-B associated with nicotine addiction and inflammation

6) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 1.27 Pain Relevance 0.08

Here, the distinct measurement of MAO activities and of MAO protein concentrations shows that the FS group accounts for the significantly higher platelet MAO-B activity found in “current non-smokers”.

Positive_regulation (accounts) of MAO-B in platelet associated with nicotine addiction

7) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 1.14 Pain Relevance 0.03

Moreover, ex vivo animal experiments showed that tobacco smoke induced a reduction in the MAOB promoter methylation.

Positive_regulation (induced) of MAOB associated with nicotine addiction

8) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 1.13 Pain Relevance 0.14

The present results reassert that MAO-B activity is inhibited by smoking and reveal for the first time that (i) platelet MAO-B protein concentration increased during smoking and (ii) this increase lasted long after quitting smoking (13 yrs average in our FS group, Table 2). 5-HT Catabolism and Cardiovascular Risk

Positive_regulation (increased) of platelet MAO-B protein in platelet associated with nicotine addiction

9) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 1.28 Pain Relevance 0

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