INT56088

Context Info Confidence 0.46 First Reported 1994 Last Reported 1994 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0.83 Pain Relevance 0.57

extracellular space (TGFB1, SERPINE1) extracellular region (TGFB1, SERPINE1) aging (TGFB1) enzyme binding (TGFB1) embryo development (TGFB1) cytoplasm (TGFB1)

Anatomy Link Frequency fibroblast 4 TGFB1 (Homo sapiens) SERPINE1 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 14 91.96 cINOD 2 65.44 dexamethasone 2 62.08 Arthritis 2 29.28

Disease Link Frequency Relevance Heat Necrosis 4 99.22 Cancer 4 99.04 INFLAMMATION 2 65.04 Disease 2 5.00 Arthritis 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Tumor necrosis factor alpha (TNF alpha) reduced, and transforming growth factor-beta (TGF-beta) and basic fibroblast growth factor (bFGF) increased, the levels of PAI-1 antigen and mRNA in the culture fluids and cell extracts, respectively.

TGF-beta Positive_regulation (increased) of Transcription (levels) of PAI-1 in fibroblast associated with necrosis and cancer

1) Confidence 0.46 Published 1994 Journal Biochim. Biophys. Acta Section Abstract Doc Link 8054359 Disease Relevance 0.41 Pain Relevance 0.29

Tumor necrosis factor alpha (TNF alpha) reduced, and transforming growth factor-beta (TGF-beta) and basic fibroblast growth factor (bFGF) increased, the levels of PAI-1 antigen and mRNA in the culture fluids and cell extracts, respectively.

transforming growth factor-beta Positive_regulation (increased) of Transcription (levels) of PAI-1 in fibroblast associated with necrosis and cancer

2) Confidence 0.46 Published 1994 Journal Biochim. Biophys. Acta Section Abstract Doc Link 8054359 Disease Relevance 0.41 Pain Relevance 0.29

General Comments

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