INT56207

Context Info Confidence 0.47 First Reported 1994 Last Reported 2010 Negated 1 Speculated 0 Reported most in Abstract Documents 7 Total Number 7 Disease Relevance 1.08 Pain Relevance 0.62

cytosol (Nqo1) oxidoreductase activity (Nqo1) aging (Nqo1) cytoplasm (Nqo1)

Anatomy Link Frequency HeLa 4 liver 2 nucleus 2 Nqo1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Inflammation 9 99.82 Central grey 1 99.32 Spinal cord 3 86.68 cINOD 4 86.48 dorsal root ganglion 1 76.76 aspirin 8 25.00 qutenza 2 25.00 spinal dorsal horn 1 25.00 Hyperalgesia 1 25.00 anesthesia 3 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 9 99.82 Urological Neuroanatomy 1 99.32 Prostate Cancer 28 88.64 Cancer 7 78.64 Ganglion Cysts 1 76.76 Stress 4 68.20 Pancreatitis 3 63.56 Alcoholic Pancreatitis 3 50.00 Bladder Cancer 4 45.32 Hyperalgesia 1 25.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Moreover, NQO1 gene silencing in HeLa cells by transfection of a small interfering RNA resulted in lowering of both the NQO1 protein level and the NQO1 activity by about 75%.

Positive_regulation (resulted) of Positive_regulation (lowering) of NQO1 in HeLa

1) Confidence 0.47 Published 2008 Journal Biofactors Section Abstract Doc Link 19096101 Disease Relevance 0 Pain Relevance 0

Moreover, NQO1 gene silencing in HeLa cells by transfection of a small interfering RNA resulted in lowering of both the NQO1 protein level and the NQO1 activity by about 75%.

Positive_regulation (resulted) of Positive_regulation (lowering) of NQO1 in HeLa

2) Confidence 0.47 Published 2008 Journal Biofactors Section Abstract Doc Link 19096101 Disease Relevance 0 Pain Relevance 0

Unilateral hindpaw inflammation did not result in an increase in NADPH-diaphorase activity in the periaqueductal gray or the ventroposteriolateral thalamic nucleus.

Neg (not) Positive_regulation (result) of Positive_regulation (increase) of NADPH-diaphorase in nucleus associated with inflammation and central grey

3) Confidence 0.47 Published 1994 Journal Brain Res. Section Abstract Doc Link 8069693 Disease Relevance 0.35 Pain Relevance 0.26

The quinone-forming family, including NCX 4040 and conisogenic bromides and mesylate, was rapidly bioactivated to a quinone, which gave activation of ARE and consequent induction of NQO1 in liver cells.

Positive_regulation (activation) of Positive_regulation (induction) of NQO1 in liver

4) Confidence 0.45 Published 2007 Journal Chem. Res. Toxicol. Section Abstract Doc Link 17975886 Disease Relevance 0.22 Pain Relevance 0.17

Although the control family, including NCX 4016 and conisogenic bromides and mesylates, cannot form a quinone, ARE activation and NQO1 induction were observed, compatible with slower SN2 reactions with thiol sensor proteins, and consequent ARE-luciferase and NQO1 induction.

Positive_regulation (activation) of Positive_regulation (induction) of NQO1

5) Confidence 0.45 Published 2007 Journal Chem. Res. Toxicol. Section Abstract Doc Link 17975886 Disease Relevance 0.22 Pain Relevance 0.16

A number of compounds effective at inducing phase 2 enzyme activity have been identified by screening for nicotinomide quinone oxidoreductase (NQO1) enzymatic induction in the Hepa 1c1c7 cell line [10-12].

Positive_regulation (screening) of Positive_regulation (induction) of NQO1

6) Confidence 0.44 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1421427 Disease Relevance 0.22 Pain Relevance 0.03

RESULTS: Frequencies of the gene deletion of GSTM1 and GSTT1 in addition to the C-allele frequency of NQO1 tended to be higher in the alcoholic patients with (AlCP) or without pancreatic dysfunction (Alc) than in the healthy controls although the difference was not significant.

Positive_regulation (tended) of Positive_regulation (frequency) of NQO1

7) Confidence 0.12 Published 2010 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 18986377 Disease Relevance 0.06 Pain Relevance 0

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