INT56226

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Context Info
Confidence 0.25
First Reported 1994
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.60
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophages 1
astrocytes 1
microglia 1
peritoneal macrophages 1
RT1-EC2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
potassium channel 12 100.00 Very High Very High Very High
Glutamate receptor 6 100.00 Very High Very High Very High
Neuritis 7 98.12 Very High Very High Very High
Inflammation 57 98.06 Very High Very High Very High
antidepressant 6 93.56 High High
Endep 3 87.52 High High
Nortriptyline 2 86.92 High High
monoamine 7 75.00 Quite High
Glutamate 54 66.96 Quite High
Central nervous system 108 55.92 Quite High
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 7 98.12 Very High Very High Very High
INFLAMMATION 78 98.06 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 249 94.48 High High
Anxiety Disorder 9 88.92 High High
Neurodegenerative Disease 84 86.56 High High
Infection 102 72.88 Quite High
Death 36 24.80 Low Low
Apoptosis 6 13.44 Low Low
Stress 42 5.00 Very Low Very Low Very Low
Disease 36 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study examined the modulation of IFN-gamma induced MHC class I and II expression on normal Lewis rats and rats with EAN peritoneal macrophages cultured in the absence or presence of 10(-4)-10(-8) M of the 5-HT reuptake inhibiting antidepressants zimeldine, and its metabolites norzimeldine and cpp200 oxalate as well as the antidepressants clomipramine and imipramine, in addition amitriptyline, nortriptyline and maprotiline in EAN rats.
Spec (examined) Positive_regulation (induced) of MHC class I and II in peritoneal macrophages associated with nortriptyline, antidepressant, endep and neuritis
1) Confidence 0.25 Published 1994 Journal Immunopharmacology Section Abstract Doc Link 8071062 Disease Relevance 0.33 Pain Relevance 0.62
Inflammatory molecules released from microglia/macrophages and astrocytes evoke NMDAR activation, as well as activation of metabotropic glutamate receptors (mGluR), receptor tyrosine kinases (RTK), voltage-gated potassium channels (Kv), other G-protein-coupled receptors (GPCR), and potentially major histocompatability complex subtype 1 receptors (MHC I).
Positive_regulation (activation) of MHC I in astrocytes associated with inflammation, glutamate receptor and potassium channel
2) Confidence 0.01 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 1.09 Pain Relevance 0.29
Inflammatory molecules released from microglia/macrophages and astrocytes evoke NMDAR activation, as well as activation of metabotropic glutamate receptors (mGluR), receptor tyrosine kinases (RTK), voltage-gated potassium channels (Kv), other G-protein-coupled receptors (GPCR), and potentially major histocompatability complex subtype 1 receptors (MHC I).
Positive_regulation (activation) of MHC I in microglia associated with inflammation, glutamate receptor and potassium channel
3) Confidence 0.00 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 1.09 Pain Relevance 0.29
Inflammatory molecules released from microglia/macrophages and astrocytes evoke NMDAR activation, as well as activation of metabotropic glutamate receptors (mGluR), receptor tyrosine kinases (RTK), voltage-gated potassium channels (Kv), other G-protein-coupled receptors (GPCR), and potentially major histocompatability complex subtype 1 receptors (MHC I).
Positive_regulation (activation) of MHC I in macrophages associated with inflammation, glutamate receptor and potassium channel
4) Confidence 0.00 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 1.09 Pain Relevance 0.29

General Comments

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