INT56491

Context Info Confidence 0.12 First Reported 1993 Last Reported 2009 Negated 1 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 3.38 Pain Relevance 0.59

signal transduction (Tnfrsf8) molecular_function (Tnfrsf8) cellular_component (Tnfrsf8)

Anatomy Link Frequency T-cell 2 macrophages 1 Tnfrsf8 (Rattus norvegicus)

Pain Link Frequency Relevance Heat spinal stenosis 1 80.48 imagery 1 76.92 Inflammation 7 75.00 headache 1 74.20 Pain 3 74.04 Neuritis 1 73.32 Spinal cord 2 70.32 fibrosis 1 67.04 backache 3 59.36 Inflammatory marker 2 54.12

Disease Link Frequency Relevance Heat Lymphatic System Cancer 30 98.24 Cancer 3 90.64 Mycobacterial Infection 4 87.68 Disease 24 87.44 Diffuse Large B-cell Lymphoma 1 87.44 Empyema Thoracis 5 84.52 Spinal Tuberculosis 1 84.00 Lymphadenopathy 3 81.84 Spinal Stenosis 1 80.48 Pneumothorax 1 78.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Cells within the specimen were positive for CD30 and CD20 (Figure 6).

Positive_regulation (positive) of CD30

1) Confidence 0.12 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2311296 Disease Relevance 1.04 Pain Relevance 0.16

Surface antigen expression was further investigated in cultured cells, showing that the cultured cells did not express representative B-cell markers, except for CD20, as well as T-cell markers, but were positive for CD16, CD30, and CD103.

Neg (not) Positive_regulation (positive) of CD30 in T-cell

2) Confidence 0.03 Published 2005 Journal Virchows Arch. Section Abstract Doc Link 16021507 Disease Relevance 1.24 Pain Relevance 0.07

Some of the macrophages were also activated (CD4+/CD11c+/CD25+/CD30-).

Positive_regulation (activated) of CD30 in macrophages

3) Confidence 0.02 Published 1993 Journal J. Submicrosc. Cytol. Pathol. Section Abstract Doc Link 8096431 Disease Relevance 0.89 Pain Relevance 0.24

Immunoperoxidase stains performed on the cell block/core specimen showed that the large atypical cells were positive for CD2, CD30, CD43 and CD56, TIA-1, granzyme, and perforin, but for none of the other T-cell markers used (CD3, CD4, CD5, CD8, CD45RO), which stained the abundant background lymphocytes.

Positive_regulation (positive) of CD30 in T-cell

4) Confidence 0.01 Published 2009 Journal Diagn. Cytopathol. Section Abstract Doc Link 19373919 Disease Relevance 0.21 Pain Relevance 0.11

General Comments

This test has worked.