INT5652

Context Info Confidence 0.37 First Reported 1991 Last Reported 2006 Negated 0 Speculated 1 Reported most in Abstract Documents 7 Total Number 8 Disease Relevance 2.46 Pain Relevance 1.21

peptidase activity (ELANE) extracellular region (ELANE) cytoplasm (ELANE)

Anatomy Link Frequency neutrophil 5 eosinophils 3 leukocyte 2 heart 2 ELANE (Homo sapiens)

Pain Link Frequency Relevance Heat anesthesia 7 99.88 Acupuncture 62 98.08 Inflammation 19 75.00 cINOD 3 68.00 Pain 4 5.00 fibrosis 1 5.00 rheumatoid arthritis 1 5.00 Crohn's disease 1 5.00 headache 1 5.00 nud 1 5.00

Disease Link Frequency Relevance Heat Sepsis 2 98.40 Hypersensitivity 6 97.82 Infection 3 97.80 Disease 7 96.40 Neutrophil Disorders 22 96.08 Neutropenia 3 91.32 Urological Neuroanatomy 4 90.04 INFLAMMATION 20 75.00 Renal Failure 2 72.72 Agranulocytosis 17 61.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

causes accumulation of canine neutrophil elastase in the cytosolic compartments [12], and mutations in ELA2 may disrupt the AP3?

Spec (may) Negative_regulation (disrupt) of Positive_regulation (accumulation) of elastase in neutrophil

1) Confidence 0.37 Published 2004 Journal BMC Blood Disord Section Body Doc Link PMC535939 Disease Relevance 0.62 Pain Relevance 0

Moreover, either needle puncture or electro-acupuncture stimulation to Zhongfu and Tiantu significantly reverted the human neutrophil elastase-induced decrease in tracheal mucociliary transport velocity and human neutrophil elastase -induced increase in the contents of fucose and protein in the tracheal lavage, compared with the control group.

Negative_regulation (decrease) of Positive_regulation (increase) of neutrophil elastase in neutrophil associated with acupuncture

2) Confidence 0.33 Published 2006 Journal BMC Complement Altern Med Section Abstract Doc Link PMC1397865 Disease Relevance 0.17 Pain Relevance 0.31

The administration of ulinastatin can inhibit the increase of GE.

Negative_regulation (inhibit) of Positive_regulation (increase) of GE

3) Confidence 0.23 Published 1991 Journal Masui Section Abstract Doc Link 1942515 Disease Relevance 0.26 Pain Relevance 0.24

In patients given ulinastatin during anesthesia, the increase in GE during the operation was suppressed but an increase after the operation was observed.

Negative_regulation (suppressed) of Positive_regulation (increase) of GE associated with anesthesia

4) Confidence 0.23 Published 1991 Journal Masui Section Abstract Doc Link 1942515 Disease Relevance 0.24 Pain Relevance 0.27

We conclude that NPC 15669 is an effective inhibitor of antigen-induced leukocyte recruitment and elastase release and subsequent hypersecretion in airways.

Negative_regulation (inhibitor) of Positive_regulation (antigen-induced) of elastase in leukocyte

5) Confidence 0.06 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7943251 Disease Relevance 0.31 Pain Relevance 0.10

In allergic dogs in vivo, NPC 15669 (10(-5) M) prevented antigen-induced recruitment of eosinophils and neutrophils and prevented the increase in elastase and lysozyme concentrations.

Negative_regulation (prevented) of Positive_regulation (increase) of elastase in eosinophils associated with hypersensitivity

6) Confidence 0.06 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7943251 Disease Relevance 0.32 Pain Relevance 0.11

In allergic dogs in vivo, NPC 15669 (10(-5) M) prevented antigen-induced recruitment of eosinophils and neutrophils and prevented the increase in elastase and lysozyme concentrations.

Negative_regulation (prevented) of in neutrophils Positive_regulation (increase) of elastase in eosinophils associated with hypersensitivity

7) Confidence 0.02 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7943251 Disease Relevance 0.32 Pain Relevance 0.11

[Prostaglandin E1 infusion fails to inhibit the increase of serum granulocyte elastase and myeloperoxidase and the decrease of plasma angiotensin converting enzyme in patients undergoing open-heart surgery].

Negative_regulation (inhibit) of Positive_regulation (increase) of serum granulocyte elastase in heart

8) Confidence 0.01 Published 1992 Journal Masui Section Title Doc Link 1313120 Disease Relevance 0.23 Pain Relevance 0.07

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