INT56686

Context Info Confidence 0.44 First Reported 1993 Last Reported 2010 Negated 4 Speculated 1 Reported most in Abstract Documents 26 Total Number 27 Disease Relevance 3.43 Pain Relevance 24.48

cytoplasm (Vta1)

Anatomy Link Frequency neurons 5 DA neurons 2 NAC 2 ventral 2 brain 1 Vta1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Ventral tegmentum 336 100.00 Morphine 111 100.00 gABA 45 100.00 cocaine 36 100.00 opioid receptor 9 100.00 Opioid 100 99.98 Dynorphin 4 99.98 Dopamine 200 99.96 Nucleus accumbens 73 99.92 Substantia nigra 24 99.90

Disease Link Frequency Relevance Heat Stress 28 99.82 Herpes Simplex Virus 1 99.36 Death 4 97.52 Sprains And Strains 3 95.96 Toxicity 9 94.04 Anxiety Disorder 2 88.32 Cognitive Disorder 6 87.92 Nociception 1 79.20 Depression 17 76.52 Drug Dependence 6 76.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

For example, recent work from our lab has shown that, while lesions of the SNC-projecting aPPTg do not affect nicotine self-administration, pPPTg lesions increase it, an effect likely to be the result of altered regulation of VTA DA neurons (Alderson et al. 2006).

Regulation (regulation) of VTA in DA neurons associated with ventral tegmentum, dopamine and nicotine

1) Confidence 0.44 Published 2008 Journal Brain Struct Funct Section Body Doc Link PMC2522332 Disease Relevance 0 Pain Relevance 0.77

However, dopaminergic SN and VTA neurons differ on several functional levels, and dopaminergic SN neurons themselves vary in their intrinsic electrical properties, neurochemical characteristics and connections.

Regulation (differ) of VTA in neurons associated with ventral tegmentum and substantia nigra

2) Confidence 0.39 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19261887 Disease Relevance 0.07 Pain Relevance 0.45

These results demonstrate the marked sensitivity of these neurons to ethanol and suggest that chronic ethanol administration produces selective adaptive circuit responses within the VTA or in extrategmental structures that regulate VTA GABA neuron activity.

Regulation (regulate) of VTA in neuron associated with ventral tegmentum and gaba

3) Confidence 0.39 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10565823 Disease Relevance 0 Pain Relevance 0.82

Detailed phenotypical analyses in the amygdala and ventral tegmental area (VTA) show that specific subpopulations in the BLA are differentially involved in the formation and retrieval of withdrawal memories, and strikingly that a population of VTA dopamine neurons is activated in both situations.

Regulation (population) of VTA in amygdala associated with ventral tegmentum, dopamine, withdrawal and amygdala

4) Confidence 0.34 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15703390 Disease Relevance 0 Pain Relevance 0.95

On the other hand, VTA is modulated by GABAergic inputs [15,16].

Regulation (modulated) of VTA associated with ventral tegmentum and gabaergic

5) Confidence 0.24 Published 2003 Journal BMC Psychiatry Section Body Doc Link PMC293465 Disease Relevance 0.12 Pain Relevance 1.04

Sprague-Dawley rats were implanted with guide cannula targeting the VTA, after which a heroin-induced CPP dose-response curve was determined (2.5-40 ng administered bilaterally in 0.5 microl/side).

Regulation (targeting) of VTA

6) Confidence 0.24 Published 2005 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 16297973 Disease Relevance 0 Pain Relevance 0.17

We evaluated the effects of local and systemic ethanol on VTA GABA neuron spontaneous activity in ethanol naive and chronically treated freely behaving rats and in anesthetized rats.

Regulation (effects) of VTA in neuron associated with ventral tegmentum and gaba

7) Confidence 0.24 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10565823 Disease Relevance 0 Pain Relevance 0.61

Overall, our results indicate that the systemic administration of SSRI alters the activity of midbrain DA neurons with differential effects on VTA compared with SNC DA neurons.

Regulation (effects) of VTA in midbrain associated with ventral tegmentum, dopamine, midbrain and ssri

8) Confidence 0.23 Published 2007 Journal Synapse Section Abstract Doc Link 17117425 Disease Relevance 0 Pain Relevance 1.17

This effect might be due to the modulation of VTA-DA neurons projecting to the VP rather than to the NAC.

Regulation (modulation) of VTA-DA in NAC associated with nucleus accumbens and ventral tegmentum

9) Confidence 0.22 Published 1998 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9784077 Disease Relevance 0 Pain Relevance 1.05

URB597 did not alter the effects of either cocaine or morphine on VTA DA neurons.

Neg (not) Regulation (effects) of VTA in DA neurons associated with ventral tegmentum, dopamine, morphine and cocaine

10) Confidence 0.20 Published 2010 Journal Addict Biol Section Abstract Doc Link 20477753 Disease Relevance 0.07 Pain Relevance 1.64

The posterior VTA has been shown to predominantly project to the medial part of the ventral striatum, including the medial shell, while the anterolateral VTA largely projects to the lateral part of the ventral striatum, including the core [17].

Regulation (anterolateral) of VTA in lateral associated with ventral tegmentum

11) Confidence 0.19 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2930627 Disease Relevance 0 Pain Relevance 0.49

Figure 3 summarizes the percent decrease in amplitude of the sensory (acoustic) evoked responses for P3 component as compared to control recording in the VTA, NAc, and PFC.

Regulation (control) of VTA associated with nucleus accumbens and ventral tegmentum

12) Confidence 0.18 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1360669 Disease Relevance 0 Pain Relevance 0.38

Because opioids modulate feeding in the VTA and Acb, we hypothesized that ghrelin's effects in one site were dependent on opioid signaling in the opposite site.

Regulation (modulate) of VTA in Acb associated with nucleus accumbens, ventral tegmentum and opioid

13) Confidence 0.16 Published 2005 Journal Peptides Section Abstract Doc Link 16137788 Disease Relevance 0 Pain Relevance 1.07

In contrast, intra-mPfc TTX decreased local GABA (-33+6%) while VTA GABA levels were not affected.

Neg (not) Regulation (affected) of VTA associated with ventral tegmentum and gaba

14) Confidence 0.16 Published 2002 Journal J. Neurosci. Methods Section Abstract Doc Link 12323414 Disease Relevance 0 Pain Relevance 1.13

MPfc GABA was also rapidly increased (+241+/-62%) while VTA GABA was not affected.

Neg (not) Regulation (affected) of VTA associated with ventral tegmentum and gaba

15) Confidence 0.16 Published 2002 Journal J. Neurosci. Methods Section Abstract Doc Link 12323414 Disease Relevance 0 Pain Relevance 1.10

Besides the short-loop feedback inhibition exerted by dopamine, the activity of VTA dopaminergic neurones is strongly modulated by glutamatergic and GABAergic inputs.

Regulation (modulated) of VTA associated with ventral tegmentum, dopamine and gabaergic

16) Confidence 0.15 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526276 Disease Relevance 0 Pain Relevance 1.16

In the VTA, neither 2 nor 14 days of bupropion administration altered the firing and burst activity of dopamine neurons.

Regulation (altered) of VTA in dopamine neurons associated with ventral tegmentum and dopamine

17) Confidence 0.15 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18708076 Disease Relevance 0.05 Pain Relevance 0.66

To determine whether there is a synaptic basis for ENK and/or dynorphin modulation of cortically projecting neurons within the VTA, we combined retrograde tract-tracing from the mPFC with dual immunocytochemical-labeling electron microscopy in the rat VTA.

Spec (whether) Regulation (modulation) of VTA in neurons associated with ventral tegmentum, dynorphin and enkephalin

18) Confidence 0.14 Published 2004 Journal Synapse Section Abstract Doc Link 14755631 Disease Relevance 0.26 Pain Relevance 1.20

In contrast to NFs, no P-NP line differences were found in VTA levels of tyrosine hydroxylase, which is also regulated by chronic morphine and cocaine treatments in Sprague-Dawley rats and shows prominent Lewis-Fischer strain differences, specifically in this brain region.

Regulation (regulated) of VTA in brain associated with ventral tegmentum, sprains and strains, cocaine and morphine

19) Confidence 0.12 Published 1993 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 8101433 Disease Relevance 0.25 Pain Relevance 1.03

Detailed phenotypical analyses in the amygdala and ventral tegmental area (VTA) show that specific subpopulations in the BLA are differentially involved in the formation and retrieval of withdrawal memories, and strikingly that a population of VTA dopamine neurons is activated in both situations.

Regulation (population) of VTA in ventral associated with ventral tegmentum, dopamine, withdrawal and amygdala

20) Confidence 0.11 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15703390 Disease Relevance 0 Pain Relevance 0.95

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