INT569

Context Info Confidence 0.42 First Reported 1975 Last Reported 2010 Negated 0 Speculated 1 Reported most in Abstract Documents 13 Total Number 15 Disease Relevance 9.48 Pain Relevance 2.85

extracellular space (C4a) extracellular region (C4a) molecular_function (C4a)

Anatomy Link Frequency plasma 1 liver 1 spinal cord 1 respiratory 1 C4a (Rattus norvegicus)

Pain Link Frequency Relevance Heat Spinal cord 4 100.00 Kinase C 2 100.00 depression 2 100.00 Clonidine 1 99.04 peripheral neuropathy 2 97.94 Cholecystokinin 5 97.80 anesthesia 5 96.12 Raphe 5 94.60 bradykinin 1 93.84 Inflammation 43 92.48

Disease Link Frequency Relevance Heat Depression 2 100.00 Spinal Cord Injury 2 100.00 Cryoglobulinemia 6 99.30 Disease 218 98.92 Increased Venous Pressure Under Development 22 98.88 Anaemia 7 98.48 Hematuria 3 98.32 Schnitzler Syndrome 64 98.24 Hyperplasia 2 98.20 Systemic Lupus Erythematosus 56 98.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The pancreatic responses were completely abolished by spinal cord transection at the level between C4 and C5.

Negative_regulation (abolished) of C4 in spinal cord associated with spinal cord

1) Confidence 0.42 Published 1995 Journal Pancreas Section Abstract Doc Link 7792298 Disease Relevance 0.18 Pain Relevance 0.36

Long-lasting depression of the respiratory rhythm (C4 and Pre-I activity) by clonidine, which might decrease intracellular cAMP level via alpha 2-receptors, was reversed by forskolin.

Negative_regulation (depression) of C4 in respiratory associated with depression and clonidine

2) Confidence 0.33 Published 1993 Journal Brain Res. Section Abstract Doc Link 7683235 Disease Relevance 0.19 Pain Relevance 0.36

The diagnosis can be confirmed by finding low levels of C1 esterase inhibitor, C4 and C2.

Negative_regulation (inhibitor) of C4

3) Confidence 0.25 Published 1992 Journal J Assoc Physicians India Section Abstract Doc Link 1452538 Disease Relevance 0.63 Pain Relevance 0.09

The relative increase in serum C3 protein and decrease in C4 protein could explain changes in the C3/C4 ratio.

Negative_regulation (decrease) of C4

4) Confidence 0.19 Published 2007 Journal Am. J. Cardiol. Section Abstract Doc Link 17398178 Disease Relevance 0.31 Pain Relevance 0.05

Most patients have decreased plasma complement protein C4 levels.

Negative_regulation (decreased) of C4 in plasma

5) Confidence 0.14 Published 2008 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 18241690 Disease Relevance 0.84 Pain Relevance 0.12

Subsequently, total hemolytic activity (CH50) levels were variable, complement component protein concentrations of C1q, C1s, C4, C2, C3, C5, C6, C9, and Factor B were normal, but hemolytic activity of C4 and C2 was diminished.

Negative_regulation (diminished) of C4

6) Confidence 0.08 Published 1975 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 50336 Disease Relevance 0.31 Pain Relevance 0.38

CCK's secretagogue effect was independent of electrical stimulation and extracellular Ca2+ and was blocked by an inhibitor of protein kinase C. 4.

Negative_regulation (inhibitor) of C. 4 associated with kinase c and cholecystokinin

7) Confidence 0.08 Published 1989 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 2575930 Disease Relevance 0 Pain Relevance 0.50

Laboratory findings revealed proteinuria, hematuria, anemia, leucopenia, a high titer of antinuclear antibodies (ANA), anti-dsDNA, and decreased complement (C3 and C4) levels.

Negative_regulation (decreased) of C4 associated with anaemia, proteinuria and hematuria

8) Confidence 0.07 Published 2010 Journal Clin. Exp. Nephrol. Section Abstract Doc Link 20054604 Disease Relevance 1.62 Pain Relevance 0.09

A longitudinal study is needed to determine whether there is an association between a reduction in C4 levels and an increase in disease activity in SLE as measured by the BILAG-2004 index.

Spec (whether) Negative_regulation (reduction) of C4 associated with systemic lupus erythematosus and disease

9) Confidence 0.06 Published 2007 Journal Arthritis and Rheumatism Section Body Doc Link PMC2659367 Disease Relevance 0.54 Pain Relevance 0

In both groups of patients the serum concentrations of C3, C4, C5, and C1 inhibitor were significantly affected by the treatments (p < 0.001), decreased immediately after onset of anesthesia, were minimal during surgery, and increased thereafter.

Negative_regulation (inhibitor) of C4 associated with anesthesia

10) Confidence 0.04 Published 1999 Journal Pediatr Cardiol Section Abstract Doc Link 9986887 Disease Relevance 0.17 Pain Relevance 0.13

Increasing overall scores on the BILAG-2004 index were associated with increasing ESRs, decreasing C3 levels, decreasing C4 levels, elevated anti-dsDNA levels, and increasing SLEDAI-2K scores (all P < 0.01).

Negative_regulation (decreasing) of C4

11) Confidence 0.04 Published 2007 Journal Arthritis and Rheumatism Section Abstract Doc Link PMC2659367 Disease Relevance 0.66 Pain Relevance 0

Subsequently, total hemolytic activity (CH50) levels were variable, complement component protein concentrations of C1q, C1s, C4, C2, C3, C5, C6, C9, and Factor B were normal, but hemolytic activity of C4 and C2 was diminished.

Negative_regulation (diminished) of C4

12) Confidence 0.04 Published 1975 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 50336 Disease Relevance 0.30 Pain Relevance 0.37

When complement levels are lowered, another diagnosis must be considered, especially hypocomplementic urticarial vasculitis and cryoglobulinemia, and the possibility of a genetic deficiency of C4 should be addressed, since 2 patients with Schnitzler syndrome had a C4a deficiency [42].

Negative_regulation (deficiency) of C4 associated with cryoglobulinemia, increased venous pressure under development and schnitzler syndrome

13) Confidence 0.03 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018454 Disease Relevance 1.49 Pain Relevance 0.09

Associated findings include pseudoxanthum elasticum in 2 patients [44,45], peripheral neuropathy with the presence of monoclonal IgM with anti-MAG (myelin-associated glycoprotein) in 1 patient [46], C4 deficiency in 2 patients [42] and nodular regenerative hyperplasia of the liver in 1 patient [47], impairment of renal function in 1 patient [48], thrombophilia with anti-phospholipid antibodies and hyperhomocysteinemia [49] and hearing loss [3].

Negative_regulation (deficiency) of C4 in liver associated with deafness, thrombophilia, peripheral neuropathy, hyperhomocysteinemia and hyperplasia

14) Confidence 0.02 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018454 Disease Relevance 2.06 Pain Relevance 0.18

The concentration of routine laboratory parameters, components of the complement system (C3, C4, C5, C1 inhibitor, total hemolytic complement, C3d, and C5a), circulating interleukins (IL-6 and IL-8) and soluble adhesion molecules (sICAM-1 and sE-selectin) were determined.

Negative_regulation (inhibitor) of C4 associated with adhesions

15) Confidence 0.02 Published 1999 Journal Pediatr Cardiol Section Abstract Doc Link 9986887 Disease Relevance 0.17 Pain Relevance 0.11

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