INT57272

Context Info Confidence 0.43 First Reported 1994 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 16 Total Number 16 Disease Relevance 11.42 Pain Relevance 1.93

extracellular space (FN1) extracellular region (FN1) cell adhesion (FN1) proteinaceous extracellular matrix (FN1)

Anatomy Link Frequency synovial cells 2 fibroblast 2 blood cells 2 neutrophil 2 FN1 (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 84 98.28 antagonist 53 98.12 Inflammatory mediators 1 97.52 Snapping jaw 15 95.60 agonist 43 92.36 COX-2 inhibitor 8 88.96 Analgesic 5 87.28 Inflammation 46 85.52 Spinal cord 37 83.28 metalloproteinase 12 82.76

Disease Link Frequency Relevance Heat Cancer 238 100.00 Neutropenia 73 100.00 Necrosis 13 100.00 Urological Neuroanatomy 2 100.00 Non-small-cell Lung Cancer 38 99.68 Mixed Connective Tissue Disorder 1 98.82 Frailty 7 98.64 Primary Sclerosing Cholangitis 88 98.48 Pain 85 98.28 Wound Healing 4 98.18

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Normal disk tissues revealed weak fibronectin expression, which was mainly located along the collagen bundles.

Negative_regulation (revealed) of Gene_expression (expression) of fibronectin

1) Confidence 0.43 Published 2004 Journal J Craniofac Surg Section Abstract Doc Link 15213552 Disease Relevance 0.67 Pain Relevance 0.60

RESULTS: Disc specimens with advanced morphologic pathology showed significant labeling for fibronectin in 3 of 3 cases and for collagen I in 4 of 4 cases.

Negative_regulation (labeling) of Gene_expression (significant) of fibronectin

2) Confidence 0.41 Published 2009 Journal J. Oral Maxillofac. Surg. Section Body Doc Link 19070755 Disease Relevance 0 Pain Relevance 0

This may explain why transcriptomic analysis of blood cells performed in the present study failed to readily detect FN1 expression and a potential association with clinical outcome of MI patients (i.e., FN1 is not differentially expressed by HF and non-HF patients).

Neg (failed) Negative_regulation (detect) of Gene_expression (expression) of FN1 in blood cells associated with myocardial infarction

3) Confidence 0.39 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2890499 Disease Relevance 1.57 Pain Relevance 0.06

Wound healing and connective tissue disorders may respond to an increase in fibroblast collagenases and decreased collagen, fibronectin, and glycosaminoglycan production.

Negative_regulation (decreased) of Gene_expression (production) of fibronectin in fibroblast associated with wound healing and mixed connective tissue disorder

4) Confidence 0.15 Published 1994 Journal J. Am. Acad. Dermatol. Section Abstract Doc Link 8157787 Disease Relevance 0.93 Pain Relevance 0.06

Immunoblot analysis of cell culture supernatants showed significantly reduced fibronectin and collagen 1 levels after WIN treatment (supernatants of PSC grown to 100% confluency before initiation of treatment; Figure 7B).

Negative_regulation (reduced) of Gene_expression (levels) of fibronectin associated with primary sclerosing cholangitis

5) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 0.41 Pain Relevance 0.16

Pre-incubation with AM251 and/or AM630 (5 µM) revealed that the suppressive effect of WIN on fibronectin and collagen 1 production was partially reversible only when using both antagonists concomitantly (Figure 7B; pooled cell culture supernatanty from three independently performed experiments).

Negative_regulation (effect) of Gene_expression (production) of fibronectin associated with antagonist

6) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 0.40 Pain Relevance 0.22

regulates HIF but is defective in fibronectin assembly, indicating a possible

Negative_regulation (defective) of Gene_expression (assembly) of fibronectin

7) Confidence 0.08 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.54 Pain Relevance 0

Accumulating data from ‘real-world’ clinical practice settings indicate that patients often receive abbreviated courses of daily G-CSF and consequently obtain a reduced level of FN protection.

Negative_regulation (reduced) of Gene_expression (protection) of FN associated with neutropenia

8) Confidence 0.07 Published 2010 Journal Support Care Cancer Section Abstract Doc Link PMC2846279 Disease Relevance 0.62 Pain Relevance 0

ligands were shown to inhibit fibronectin expression in

Negative_regulation (inhibit) of Gene_expression (expression) of fibronectin

9) Confidence 0.06 Published 2007 Journal PPAR Research Section Body Doc Link PMC2220082 Disease Relevance 1.07 Pain Relevance 0.07

Thus, by inhibiting the expression of fibronectin

Negative_regulation (inhibiting) of Gene_expression (expression) of fibronectin

10) Confidence 0.06 Published 2007 Journal PPAR Research Section Body Doc Link PMC2220082 Disease Relevance 1.21 Pain Relevance 0.03

False positive (FP) and false negative (FN) results based on qPCR

Negative_regulation (negative) of Gene_expression (results) of FN

11) Confidence 0.06 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2440748 Disease Relevance 0.37 Pain Relevance 0

The concentration of Fn on all surfaces was maintained at 0.12 absorbance units cm?

Negative_regulation (maintained) of Gene_expression (concentration) of Fn

12) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.36 Pain Relevance 0

Additionally, biochemical protein analysis supplemented our stereological quantification and demonstrated no changes in protein expression levels of Fibronectin, NG2, Versican, GFAP, and PE-CAM1 at 2 weeks post-transplant.

Negative_regulation (levels) of Gene_expression (expression) of Fibronectin

13) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690693 Disease Relevance 0.42 Pain Relevance 0

reduced expression of fibronectin and its receptor integrin ?

Negative_regulation (reduced) of Gene_expression (expression) of fibronectin

14) Confidence 0.03 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528242 Disease Relevance 1.38 Pain Relevance 0.12

This was noted in other studies with the reduction of Tumor Necrosis Factor (TNF)-alpha and fibronectin RNA expression using cultured rabbit synovial cells [9].

Negative_regulation (reduction) of Gene_expression (expression) of fibronectin in synovial cells associated with necrosis and cancer

15) Confidence 0.02 Published 2004 Journal BMC Musculoskelet Disord Section Body Doc Link PMC387830 Disease Relevance 0.72 Pain Relevance 0.48

BIO5192 treatment significantly decreased the MPO enzymatic activity (neutrophil infiltration) and ED-1 expression (macrophage density) by 40% and 38% at 24 h and by 52% and 25% at 72 h post injury, respectively.

Negative_regulation (decreased) of Gene_expression (expression) of ED-1 in neutrophil associated with injury and urological neuroanatomy

16) Confidence 0.00 Published 2008 Journal Exp. Neurol. Section Abstract Doc Link 18926823 Disease Relevance 0.75 Pain Relevance 0.12

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