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Context Info
Confidence 0.59
First Reported 1975
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 60
Total Number 60
Disease Relevance 41.37
Pain Relevance 7.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (C3) extracellular space (C3) extracellular region (C3)
Anatomy Link Frequency
skin 5
neutrophil 2
ileum 1
bulla 1
CSF 1
C3 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinothalamic tract 9 100.00 Very High Very High Very High
imagery 10 99.68 Very High Very High Very High
Pain 77 99.28 Very High Very High Very High
Dismenorea 6 98.80 Very High Very High Very High
endometriosis 99 98.48 Very High Very High Very High
abdominal pain 24 98.40 Very High Very High Very High
Inflammation 106 98.02 Very High Very High Very High
agonist 10 97.32 Very High Very High Very High
spinal inflammation 10 97.20 Very High Very High Very High
Arthritis 27 96.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 36 99.98 Very High Very High Very High
Renal Disease 44 99.68 Very High Very High Very High
Sprains And Strains 53 99.62 Very High Very High Very High
Distemper 1 99.36 Very High Very High Very High
Pain 53 99.28 Very High Very High Very High
Bullous Skin Disease 12 98.94 Very High Very High Very High
Proteinuria 27 98.90 Very High Very High Very High
Endometriosis 126 98.80 Very High Very High Very High
Blister 30 98.76 Very High Very High Very High
Brain Injury 1 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immune complex phenomena occur in conjunction with C3 deficiency of dogs during canine distemper virus infection and, presumably, as a part of the beagle pain syndrome.
Negative_regulation (deficiency) of C3 associated with pain, distemper and infection
1) Confidence 0.59 Published 1989 Journal Toxicol Pathol Section Abstract Doc Link 2665030 Disease Relevance 0.75 Pain Relevance 0.10
INVESTIGATIONS: Laboratory tests revealed pancytopenia and a decrease in C3 and C4.
Negative_regulation (decrease) of C3
2) Confidence 0.58 Published 2007 Journal Dtsch. Med. Wochenschr. Section Body Doc Link 17443443 Disease Relevance 0 Pain Relevance 0
Direct immunofluorescence of a biopsy specimen from perilesional skin revealed linear deposits of immunoglobulins M and G and of C3 at the dermoepidermal junction which was consistent with mucous membrane pemphigoid.
Negative_regulation (deposits) of C3 in skin associated with pemphigoid
3) Confidence 0.42 Published 2008 Journal Skinmed Section Abstract Doc Link 18174805 Disease Relevance 1.31 Pain Relevance 0.17
Investigations were consistent with type 1 HAE, showing low C1 esterase inhibitor activity of 0.06 g/litre (normal range [NR] 0.2 to 0.65 g/litre), low complement C4 and normal complement C3.
Negative_regulation (inhibitor) of complement C3
4) Confidence 0.42 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2577685 Disease Relevance 1.51 Pain Relevance 0.24
Multivariable analysis indicated Raynaud's phenomenon, decreased C3, CH50, and anti-neutrophil cytoplasmic antibody positivity were independent predictors of gastrointestinal involvements (p < 0.05).
Negative_regulation (decreased) of C3 in neutrophil
5) Confidence 0.41 Published 2010 Journal Lupus Section Abstract Doc Link 20410154 Disease Relevance 1.30 Pain Relevance 0.11
A direct immunofluorescence study of the lesion showed an intercellular deposition of IgG and C3 in the upper epidermis.
Negative_regulation (deposition) of C3 in epidermis
6) Confidence 0.41 Published 2001 Journal J. UOEH Section Abstract Doc Link 11279842 Disease Relevance 0.78 Pain Relevance 0.09
The histopathology showed the classic features of pemphigus vulgaris, and direct immunofluorescence showed intercellular deposition of IgG and C3 in the epidermis.
Negative_regulation (deposition) of C3 in epidermis associated with bullous skin disease
7) Confidence 0.41 Published 1998 Journal Pediatr Dermatol Section Abstract Doc Link 9796590 Disease Relevance 0.89 Pain Relevance 0.31
Video fluoroscopy was performed which showed a bony prominence impeding swallow at the level of C3.
Negative_regulation (impeding) of C3
8) Confidence 0.40 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2533017 Disease Relevance 1.60 Pain Relevance 0.09
This showed a bony prominence impeding swallow at the level of C3.
Negative_regulation (impeding) of C3
9) Confidence 0.40 Published 2008 Journal J Med Case Reports Section Abstract Doc Link PMC2533017 Disease Relevance 1.06 Pain Relevance 0.03
Surgical biopsy of the ileum revealed deposits of IgA, C3, and fibrin in segments of the wall of submucosal arteries.
Negative_regulation (deposits) of C3 in ileum
10) Confidence 0.40 Published 1984 Journal Am. J. Med. Section Abstract Doc Link 6385695 Disease Relevance 0.70 Pain Relevance 0.25
In both skin biopsy samples from urticarial and purpuric eruptions, mild inflammatory infiltration by polymorphonuclear leukocytes with nuclear dust, extravasation of erythrocytes and deposition of IgM and C3 in the superficial blood vessels were observed.
Negative_regulation (deposition) of C3 in polymorphonuclear leukocytes associated with inflammation
11) Confidence 0.38 Published 2003 Journal J. Dermatol. Section Abstract Doc Link 12707469 Disease Relevance 1.13 Pain Relevance 0.13
Immunofluorescence studies revealed intensive deposition of IgG, IgA, C3, C1q, Fibrinogen, and kappa light chain with granular pattern in the capillary and mesangial area.
Negative_regulation (deposition) of C3 in capillary
12) Confidence 0.34 Published 2009 Journal Clin. Exp. Nephrol. Section Abstract Doc Link 19367362 Disease Relevance 0.77 Pain Relevance 0.27
C3 was decreased in 14 cases (12.1%), while C4 in 12 cases (10.3%).
Negative_regulation (decreased) of C3
13) Confidence 0.32 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2768236 Disease Relevance 0.67 Pain Relevance 0.06
Complement study during acute and asymptomatic periods revealed normal values of C1 esterase inhibitor, C1q, C3, C4, functional activity of C1 inhibitor and CH50.
Negative_regulation (inhibitor) of C3
14) Confidence 0.32 Published 2005 Journal Allergol Immunopathol (Madr) Section Abstract Doc Link 15777525 Disease Relevance 0.83 Pain Relevance 0.18
Therefore, on anatomical grounds, pain suspiciously resulting from the C2-C3 levels can be blocked by coagulating the ipsilateral third occipital nerve as it crosses the lateral aspect of the joint, and pain stemming below C2-C3 can be blocked by coagulating the cervical medial branches as they pass around the waists of the articular pillars above and below (18).
Negative_regulation (blocked) of C3 in articular associated with pain
15) Confidence 0.32 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693602 Disease Relevance 0.40 Pain Relevance 0.33
Total serum levels of immunoglobulin G and M were high before treatment, but immunoglobulin M levels decreased significantly in week 8 during treatment with danazol, whereas C4 levels increased and C3 levels decreased with danazol.
Negative_regulation (decreased) of C3
16) Confidence 0.30 Published 1992 Journal Am. J. Obstet. Gynecol. Section Body Doc Link 1497054 Disease Relevance 0.07 Pain Relevance 0
The laboratory findings revealed moderate proteinuria, erythrocyturia, normal renal function, normotension, reduction of C3, C4 and C1q complement with elevated C1q antibodies.
Negative_regulation (reduction) of C3 associated with proteinuria
17) Confidence 0.30 Published 2001 Journal Med. Klin. (Munich) Section Abstract Doc Link 11370607 Disease Relevance 1.14 Pain Relevance 0.14
The serum concentrations of C3, C4, and C1 esterase inhibitor remained unchanged.
Negative_regulation (inhibitor) of C3
18) Confidence 0.30 Published 1991 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 1827928 Disease Relevance 0.65 Pain Relevance 0.08
Direct immunofluorescence revealed deposition of IgG and C3 in the epidermal intercellular cement substance of lesional skin only; the pathogenetic significance of this finding is discussed.
Negative_regulation (deposition) of C3 in skin
19) Confidence 0.30 Published 1990 Journal Clin. Exp. Dermatol. Section Abstract Doc Link 2145100 Disease Relevance 0.45 Pain Relevance 0.17
Laboratory test showed that more male patients than female ones were positive for increased urine protein, but female patients were more than male ones for elevated IgM and decreased C3, and C4.
Negative_regulation (decreased) of C3 in urine
20) Confidence 0.28 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2768236 Disease Relevance 0.55 Pain Relevance 0.07

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