INT57377

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Context Info
Confidence 0.49
First Reported 1994
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.45
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Pura) cell proliferation (Pura) nucleus (Pura)
DNA binding (Pura) transcription factor binding (Pura) cytoplasm (Pura)
Anatomy Link Frequency
eosinophils 1
lung 1
Pura (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 14 99.48 Very High Very High Very High
Morphine 13 99.24 Very High Very High Very High
tolerance 2 98.44 Very High Very High Very High
addiction 5 97.88 Very High Very High Very High
withdrawal 1 88.32 High High
opiate 1 55.32 Quite High
Disease Link Frequency Relevance Heat
Hypersensitivity 6 99.84 Very High Very High Very High
INFLAMMATION 10 99.48 Very High Very High Very High
Morphine Dependence 3 92.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The levels of ssCRE-BP/Pur alpha and the transcript were not changed by chronic morphine treatment, however, the levels of an activator of ssCRE-BP/Pur alpha, which is necessary for the DNA binding, may be modulated by the treatment.
Positive_regulation (activator) of ssCRE-BP associated with morphine
1) Confidence 0.49 Published 1996 Journal FEBS Lett. Section Abstract Doc Link 8706895 Disease Relevance 0.07 Pain Relevance 0.30
These data suggest that rat lung and the eosinophils contain a 45-kDa ssCRE-BP/Pur alpha that is increased when airway inflammation occurs.
Positive_regulation (increased) of ssCRE-BP in eosinophils associated with inflammation
2) Confidence 0.49 Published 1998 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 9920198 Disease Relevance 0.69 Pain Relevance 0.29
These data suggest that the change of ssCRE-BP can be involved in the development of tolerance and dependence.
Positive_regulation (change) of ssCRE-BP associated with addiction and tolerance
3) Confidence 0.45 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8170350 Disease Relevance 0 Pain Relevance 0.91
A single stranded DNA-binding protein, ssCRE-BP/Pur alpha, in rat lung and its increase in allergic airway inflammation.
Positive_regulation (increase) of ssCRE-BP in lung associated with inflammation and hypersensitivity
4) Confidence 0.21 Published 1998 Journal Jpn. J. Pharmacol. Section Title Doc Link 9920198 Disease Relevance 0.68 Pain Relevance 0.43

General Comments

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