INT57377

Context Info Confidence 0.49 First Reported 1994 Last Reported 1998 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 4 Disease Relevance 1.45 Pain Relevance 1.93

cell differentiation (Pura) cell proliferation (Pura) nucleus (Pura) DNA binding (Pura) transcription factor binding (Pura) cytoplasm (Pura)

Anatomy Link Frequency eosinophils 1 lung 1 Pura (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 14 99.48 Morphine 13 99.24 tolerance 2 98.44 addiction 5 97.88 withdrawal 1 88.32 opiate 1 55.32

Disease Link Frequency Relevance Heat Hypersensitivity 6 99.84 INFLAMMATION 10 99.48 Morphine Dependence 3 92.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The levels of ssCRE-BP/Pur alpha and the transcript were not changed by chronic morphine treatment, however, the levels of an activator of ssCRE-BP/Pur alpha, which is necessary for the DNA binding, may be modulated by the treatment.

Positive_regulation (activator) of ssCRE-BP associated with morphine

1) Confidence 0.49 Published 1996 Journal FEBS Lett. Section Abstract Doc Link 8706895 Disease Relevance 0.07 Pain Relevance 0.30

These data suggest that rat lung and the eosinophils contain a 45-kDa ssCRE-BP/Pur alpha that is increased when airway inflammation occurs.

Positive_regulation (increased) of ssCRE-BP in eosinophils associated with inflammation

2) Confidence 0.49 Published 1998 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 9920198 Disease Relevance 0.69 Pain Relevance 0.29

These data suggest that the change of ssCRE-BP can be involved in the development of tolerance and dependence.

Positive_regulation (change) of ssCRE-BP associated with addiction and tolerance

3) Confidence 0.45 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8170350 Disease Relevance 0 Pain Relevance 0.91

A single stranded DNA-binding protein, ssCRE-BP/Pur alpha, in rat lung and its increase in allergic airway inflammation.

Positive_regulation (increase) of ssCRE-BP in lung associated with inflammation and hypersensitivity

4) Confidence 0.21 Published 1998 Journal Jpn. J. Pharmacol. Section Title Doc Link 9920198 Disease Relevance 0.68 Pain Relevance 0.43

General Comments

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