INT5756

Context Info Confidence 0.59 First Reported 1992 Last Reported 2004 Negated 2 Speculated 0 Reported most in Abstract Documents 7 Total Number 7 Disease Relevance 1.07 Pain Relevance 2.29

plasma membrane (KCNN1)

Anatomy Link Frequency peripheral nerves 2 neuronal 1 skeletal muscle 1 brain 1 oocytes 1 KCNN1 (Homo sapiens)

Pain Link Frequency Relevance Heat tetrodotoxin 10 98.44 Action potential 2 98.28 sodium channel 21 98.04 Pain 4 93.48 Potency 2 92.84 potassium channel 7 88.24 conotoxin 1 85.40 Inflammation 2 58.00 Nerve growth factor 8 25.00 neurotrophin 3 6 25.00

Disease Link Frequency Relevance Heat Nervous System Injury 4 94.40 Pain 4 93.48 Myotonic Disorders 3 82.40 Hyperkalemic Periodic Paralysis 3 81.32 INFLAMMATION 2 58.00 Injury 6 54.00 Salivary Gland Disease 1 51.68 Wallerian Degeneration 2 25.00 Paralysis 3 5.00 Functional Bowel Disorder 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

SK1 mRNA was detected almost exclusively in neuronal tissues.

Gene_expression (detected) of SK1 mRNA in neuronal

1) Confidence 0.59 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 15127180 Disease Relevance 0.11 Pain Relevance 0.07

We studied the presence and changes of human SK1 (hSK1)- and hIK1-like immunoreactivity in control and injured human dorsal root ganglia (DRG) and peripheral nerves and their regulation by key neurotrophic factors in cultured rat sensory neurones.

Gene_expression (presence) of SK1 in peripheral nerves

2) Confidence 0.15 Published 2002 Journal Brain Section Abstract Doc Link 11844726 Disease Relevance 0.24 Pain Relevance 0.18

We studied the presence and changes of human SK1 (hSK1)- and hIK1-like immunoreactivity in control and injured human dorsal root ganglia (DRG) and peripheral nerves and their regulation by key neurotrophic factors in cultured rat sensory neurones.

Gene_expression (presence) of hSK1 in peripheral nerves

3) Confidence 0.15 Published 2002 Journal Brain Section Abstract Doc Link 11844726 Disease Relevance 0.24 Pain Relevance 0.18

Specific hSkM1 RNA transcripts are expressed in adult human skeletal muscle but not in heart, brain, or uterus.

Neg (not) Gene_expression (expressed) of hSkM1 in heart

4) Confidence 0.00 Published 1992 Journal Ann. Neurol. Section Abstract Doc Link 1315496 Disease Relevance 0.16 Pain Relevance 0.44

The SCN4A gene product, hSkM1, is the human homologue of rSkM1, the tetrodotoxin-sensitive sodium channel characteristic of adult rat skeletal muscle.

Gene_expression (product) of hSkM1 in skeletal muscle associated with tetrodotoxin and sodium channel

5) Confidence 0.00 Published 1992 Journal Ann. Neurol. Section Abstract Doc Link 1315496 Disease Relevance 0.15 Pain Relevance 0.44

Single-channel recordings were obtained from outside-out patches of oocytes expressing hSkM1.

Gene_expression (expressing) of hSkM1 in oocytes

6) Confidence 0.00 Published 1994 Journal Pflugers Arch. Section Abstract Doc Link 8058462 Disease Relevance 0 Pain Relevance 0.52

Specific hSkM1 RNA transcripts are expressed in adult human skeletal muscle but not in heart, brain, or uterus.

Neg (not) Gene_expression (expressed) of hSkM1 in brain

7) Confidence 0.00 Published 1992 Journal Ann. Neurol. Section Abstract Doc Link 1315496 Disease Relevance 0.16 Pain Relevance 0.44

General Comments

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