INT57562

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Context Info
Confidence 0.77
First Reported 1994
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 52
Total Number 62
Disease Relevance 24.62
Pain Relevance 6.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (GLA) extracellular region (GLA) Golgi apparatus (GLA)
lysosome (GLA) cytoplasm (GLA)
Anatomy Link Frequency
fibroblasts 3
plasma 1
endothelial cell 1
liver 1
body 1
GLA (Homo sapiens)
Pain Link Frequency Relevance Heat
Duloxetine 2 100.00 Very High Very High Very High
Pain 586 99.86 Very High Very High Very High
Analgesic 43 99.64 Very High Very High Very High
Pain score 88 99.58 Very High Very High Very High
antagonist 29 98.88 Very High Very High Very High
dexamethasone 13 98.20 Very High Very High Very High
Nicotine 192 96.76 Very High Very High Very High
carbamazepine 18 94.68 High High
Gabapentin 21 94.08 High High
agonist 216 93.32 High High
Disease Link Frequency Relevance Heat
Fabry Disease 2799 99.96 Very High Very High Very High
Disease 1027 99.96 Very High Very High Very High
Pain 719 99.86 Very High Very High Very High
Liver Disease 2 99.40 Very High Very High Very High
Chronic Renal Failure 269 99.32 Very High Very High Very High
Proteinuria 566 99.28 Very High Very High Very High
Hepatocellular Cancer 2 99.12 Very High Very High Very High
Renal Failure 85 98.96 Very High Very High Very High
Calcification 15 97.20 Very High Very High Very High
Body Weight 42 96.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Agalsidase alpha is produced on the human fibroblast cell line, and agalsidase beta from the Chinese hamster ovary cell line.
Gene_expression (produced) of Agalsidase alpha in fibroblast
1) Confidence 0.77 Published 2006 Journal Acta Med Croatica Section Abstract Doc Link 16802573 Disease Relevance 1.09 Pain Relevance 0.14
A significant decrease was noticed during vitamin K antagonist therapy and liver disease, both instances in which the synthesis of gla containing coagulation factors is affected.
Gene_expression (synthesis) of gla in liver associated with liver disease and antagonist
2) Confidence 0.75 Published 1994 Journal Thromb. Res. Section Abstract Doc Link 8191412 Disease Relevance 0.49 Pain Relevance 0.13
However, the ability to produce high doses of alpha-galactosidase A in vitro has opened the way to clinical studies and enzyme replacement therapy has recently been validated as a therapeutic agent for FD patients in clinical trials.
Gene_expression (produce) of alpha-galactosidase A
3) Confidence 0.75 Published 2002 Journal J. Soc. Biol. Section Abstract Doc Link 12360745 Disease Relevance 0.77 Pain Relevance 0.33
However, the ability to produce high doses of alpha-galactosidase A in vitro has opened the way to preclinical studies in the mouse model, and to the development of the first clinical trials in patients with Fabry disease.
Gene_expression (produce) of alpha-galactosidase A associated with fabry disease
4) Confidence 0.75 Published 2002 Journal J. Soc. Biol. Section Abstract Doc Link 12360747 Disease Relevance 1.00 Pain Relevance 0.32
The ability to produce high doses of alpha-galactosidase A has opened the way to preclinical studies, and enzyme replacement therapy has recently been validated as a therapeutic agent in clinical trials.
Gene_expression (produce) of alpha-galactosidase A
5) Confidence 0.75 Published 2002 Journal Expert Opin Investig Drugs Section Abstract Doc Link 12387706 Disease Relevance 0.89 Pain Relevance 0.27
Agalsidase alfa (Replagal™, Shire), produced by utilizing cultured human skin fibroblasts, is registered for use at a dose of 0.2 mg/kg biweekly, and agalsidase beta (Fabrazyme™, Genzyme), produced by expression of the ?
Gene_expression (produced) of Agalsidase alfa in fibroblasts
6) Confidence 0.73 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1913555 Disease Relevance 0.76 Pain Relevance 0.12
Comparison between agalsidase alfa and agalsidase beta treatments
Gene_expression (alfa) of agalsidase
7) Confidence 0.66 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3009617 Disease Relevance 0.51 Pain Relevance 0.03
-galactosidase A (agalsidase alfa and agalsidase beta), and should therefore be avoided during enzyme replacement.


Gene_expression (alfa) of agalsidase
8) Confidence 0.66 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3009617 Disease Relevance 0.60 Pain Relevance 0.04
In patients whose renal function continues to decline while receiving agalsidase alfa at 0.2 mg/kg (eGFR decline of ?
Gene_expression (alfa) of agalsidase
9) Confidence 0.66 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3009617 Disease Relevance 0.93 Pain Relevance 0.13
However, interpretation of the study results will be meaningful only if any imbalance between the agalsidase alfa and agalsidase beta treated groups in terms of baseline parameters is corrected, and proper analysis of the data accounts for confounding factors such as gender of patients and nature of clinical events.
Gene_expression (alfa) of agalsidase
10) Confidence 0.66 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3009617 Disease Relevance 0.14 Pain Relevance 0
During hepatocellular carcinoma with elevated desgamma carboxyprothrombin, gla was found normal, denying an global impairement of the vitamin K metabolism.
Gene_expression (found) of gla associated with hepatocellular cancer
11) Confidence 0.65 Published 1994 Journal Thromb. Res. Section Abstract Doc Link 8191412 Disease Relevance 0.56 Pain Relevance 0.12
[Fabry's disease (alpha-galactosidase-A deficiency): recent therapeutic innovations].
Gene_expression (deficiency) of alpha-galactosidase-A associated with analgesic and disease
12) Confidence 0.65 Published 2002 Journal J. Soc. Biol. Section Title Doc Link 12360747 Disease Relevance 0.93 Pain Relevance 0.35
[Fabry's disease (alpha-galactosidase-A deficiency): physiopathology, clinical signs, and genetic aspects].
Gene_expression (deficiency) of alpha-galactosidase-A associated with disease
13) Confidence 0.65 Published 2002 Journal J. Soc. Biol. Section Title Doc Link 12360745 Disease Relevance 0.90 Pain Relevance 0
Accordingly, we assumed that at an equal dose of 0.2 mg/kg biweekly the reduction in LVmass would be more pronounced on agalsidase alfa than agalsidase beta treatment.
Gene_expression (pronounced) of agalsidase alfa
14) Confidence 0.63 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1913555 Disease Relevance 0.15 Pain Relevance 0
It is, however, possible that agalsidase alfa is intrinsically less antigenic than agalsidase beta in male Fabry patients.
Gene_expression (beta) of agalsidase
15) Confidence 0.63 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1913555 Disease Relevance 0.08 Pain Relevance 0
The annual costs of therapy are almost equal for both preparations at the registered dose (around € 210.000 for a 70 kg patient), and as such agalsidase alfa is five times more expensive per milligram protein than agalsidase beta.
Gene_expression (expensive) of agalsidase
16) Confidence 0.63 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1913555 Disease Relevance 0.53 Pain Relevance 0.09
It is, however, possible that agalsidase alfa is intrinsically less antigenic than agalsidase beta in male Fabry patients.
Gene_expression (beta) of agalsidase alfa
17) Confidence 0.63 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1913555 Disease Relevance 0.08 Pain Relevance 0
Accordingly, we assumed that at an equal dose of 0.2 mg/kg biweekly the reduction in LVmass would be more pronounced on agalsidase alfa than agalsidase beta treatment.
Gene_expression (pronounced) of agalsidase
18) Confidence 0.63 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1913555 Disease Relevance 0.15 Pain Relevance 0
At baseline, pain scores were not different (agalsidase alfa: median 4, range 0 to 8, agalsidase beta: median 4, range 0 -7).
Gene_expression (beta) of agalsidase alfa associated with pain score
19) Confidence 0.63 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1913555 Disease Relevance 0.62 Pain Relevance 0.45
GALA enzyme: production and treatment regimen
Gene_expression (production) of GALA enzyme
20) Confidence 0.58 Published 2008 Journal BMC Neurol Section Body Doc Link PMC2585087 Disease Relevance 0.73 Pain Relevance 0.11

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