INT5758

Context Info Confidence 0.67 First Reported 1992 Last Reported 2004 Negated 2 Speculated 0 Reported most in Abstract Documents 5 Total Number 5 Disease Relevance 0.76 Pain Relevance 1.85

plasma membrane (KCNN1)

Anatomy Link Frequency brain 2 heart 2 neuronal 1 KCNN1 (Homo sapiens)

Pain Link Frequency Relevance Heat sodium channel 24 98.04 tetrodotoxin 8 91.96 potassium channel 1 88.24 Inflammation 2 58.00 spastic colon 1 25.00

Disease Link Frequency Relevance Heat Myotonic Disorders 4 82.40 Hyperkalemic Periodic Paralysis 4 81.32 INFLAMMATION 2 58.00 Salivary Gland Disease 1 51.68 Paralysis 4 5.00 Functional Bowel Disorder 1 5.00 Hypertension 1 5.00 Disease 1 5.00 Reprotox - General 2 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

SK1 mRNA was detected almost exclusively in neuronal tissues.

Transcription (detected) of SK1 mRNA in neuronal

1) Confidence 0.67 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 15127180 Disease Relevance 0.11 Pain Relevance 0.07

Specific hSkM1 RNA transcripts are expressed in adult human skeletal muscle but not in heart, brain, or uterus.

Neg (not) Transcription (expressed) of hSkM1 in heart

2) Confidence 0.00 Published 1992 Journal Ann. Neurol. Section Abstract Doc Link 1315496 Disease Relevance 0.16 Pain Relevance 0.44

Specific hSkM1 RNA transcripts are expressed in adult human skeletal muscle but not in heart, brain, or uterus.

Transcription (transcripts) of hSkM1 in heart

3) Confidence 0.00 Published 1992 Journal Ann. Neurol. Section Abstract Doc Link 1315496 Disease Relevance 0.16 Pain Relevance 0.44

Specific hSkM1 RNA transcripts are expressed in adult human skeletal muscle but not in heart, brain, or uterus.

Neg (not) Transcription (expressed) of hSkM1 in brain

4) Confidence 0.00 Published 1992 Journal Ann. Neurol. Section Abstract Doc Link 1315496 Disease Relevance 0.16 Pain Relevance 0.44

Specific hSkM1 RNA transcripts are expressed in adult human skeletal muscle but not in heart, brain, or uterus.

Transcription (transcripts) of hSkM1 in brain

5) Confidence 0.00 Published 1992 Journal Ann. Neurol. Section Abstract Doc Link 1315496 Disease Relevance 0.16 Pain Relevance 0.44

General Comments

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