INT5759

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Context Info
Confidence 0.69
First Reported 1987
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 127
Total Number 129
Disease Relevance 53.45
Pain Relevance 53.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Ptgs1) aging (Ptgs1) Golgi apparatus (Ptgs1)
endoplasmic reticulum (Ptgs1) cytoplasm (Ptgs1) lipid binding (Ptgs1)
Anatomy Link Frequency
spinal 5
platelet 4
brain 4
spinal cord 3
stomachs 2
Ptgs1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 328 100.00 Very High Very High Very High
cINOD 252 100.00 Very High Very High Very High
aspirin 113 100.00 Very High Very High Very High
COX2 74 100.00 Very High Very High Very High
Pain 50 100.00 Very High Very High Very High
cOX1 42 100.00 Very High Very High Very High
Analgesic 40 100.00 Very High Very High Very High
Dorsal horn 7 100.00 Very High Very High Very High
Bioavailability 3 100.00 Very High Very High Very High
Paracetamol 30 99.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 439 100.00 Very High Very High Very High
Arthritis 21 100.00 Very High Very High Very High
Cancer 35 99.92 Very High Very High Very High
Renal Disease 6 99.74 Very High Very High Very High
Ulcers 46 99.68 Very High Very High Very High
Necrosis 14 99.68 Very High Very High Very High
Pancreatitis 2 99.60 Very High Very High Very High
Stress 90 99.58 Very High Very High Very High
Injury 29 99.54 Very High Very High Very High
Hyperalgesia 51 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect does not appear to be due to increased arachidonic acid release, and could be due to increased PGH synthase activity.
Positive_regulation (increased) of PGH synthase
1) Confidence 0.69 Published 1989 Journal Prostaglandins Section Abstract Doc Link 2500679 Disease Relevance 0.07 Pain Relevance 0.07
In spite of the fact that cyclooxygenase protein levels were not altered, an increase in cyclooxygenase activity was observed.
Positive_regulation (increase) of cyclooxygenase
2) Confidence 0.69 Published 2007 Journal Peptides Section Abstract Doc Link 17316899 Disease Relevance 0 Pain Relevance 0.26
Elevated spinal cyclooxygenase and prostaglandin release during hyperalgesia in diabetic rats.
Positive_regulation (Elevated) of cyclooxygenase in spinal associated with hyperalgesia, diabetes mellitus and cox1
3) Confidence 0.62 Published 2002 Journal Diabetes Section Title Doc Link 12086957 Disease Relevance 0.69 Pain Relevance 0.55
Protein levels of cyclooxygenase-2 were elevated in the spinal cord of diabetic rats, whereas cyclooxygenase-1 protein was reduced.
Positive_regulation (elevated) of cyclooxygenase in spinal cord associated with diabetes mellitus and spinal cord
4) Confidence 0.62 Published 2002 Journal Diabetes Section Abstract Doc Link 12086957 Disease Relevance 0.85 Pain Relevance 0.47
It is assumed that NO produced by excitatory amino acids may increase prostaglandin production by cyclooxygenase activation.
Positive_regulation (activation) of cyclooxygenase associated with excitatory amino acid
5) Confidence 0.62 Published 2000 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 10813554 Disease Relevance 0.47 Pain Relevance 0.81
Increased spinal cyclooxygenase activity is associated with nociception induced by tissue inflammation.
Positive_regulation (Increased) of spinal cyclooxygenase in spinal associated with nociception and inflammation
6) Confidence 0.52 Published 2000 Journal Neuroscience Section Abstract Doc Link 10842019 Disease Relevance 0.65 Pain Relevance 0.46
Western blotting demonstrated general expression of cyclooxygenase-1 in test tissues and cyclooxygenase-2 within the brain and cerebellum.
Positive_regulation (demonstrated) of cyclooxygenase in brain
7) Confidence 0.49 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15148345 Disease Relevance 0.07 Pain Relevance 0.48
The synergism between tilomisole and naproxen in this chronic arthritic model may be due to enhanced cyclooxygenase inhibitory activity.
Positive_regulation (enhanced) of cyclooxygenase associated with arthritis
8) Confidence 0.46 Published 1992 Journal Agents Actions Section Abstract Doc Link 1414694 Disease Relevance 0.93 Pain Relevance 0.52
NOAs ("peripheral analgesics") inhibit cyclooxygenase hindering activation of the peripheral nociceptor-system.
Positive_regulation (activation) of cyclooxygenase in nociceptor associated with nociceptor and analgesic
9) Confidence 0.46 Published 2000 Journal Anasthesiol Intensivmed Notfallmed Schmerzther Section Abstract Doc Link 11130128 Disease Relevance 1.08 Pain Relevance 1.91
Hyperalgesic behavior in diabetic rats is associated with both increased cyclooxygenase-2 protein and cyclooxygenase-mediated PGE(2) release.
Positive_regulation (increased) of cyclooxygenase associated with hyperalgesia and diabetes mellitus
10) Confidence 0.45 Published 2002 Journal Diabetes Section Abstract Doc Link 12086957 Disease Relevance 0.72 Pain Relevance 0.47
Experimental, epidemiologic, and clinical studies provide evidence that nonsteroidal anti-inflammatory drugs (NSAIDs), particularly the selective cyclooxygenase (COX)-2 inhibitors, including celecoxib and several phytochemicals, act as anticancer agents.
Positive_regulation (selective) of cyclooxygenase associated with inflammation and cinod
11) Confidence 0.43 Published 2005 Journal Curr Gastroenterol Rep Section Abstract Doc Link 16168238 Disease Relevance 0.34 Pain Relevance 0.24
The antiinflammatory action of guanabenz is mediated through 5-lipoxygenase and cyclooxygenase inhibition.
Positive_regulation (mediated) of cyclooxygenase associated with inflammation
12) Confidence 0.43 Published 1987 Journal Eur. J. Pharmacol. Section Title Doc Link 3121363 Disease Relevance 0.65 Pain Relevance 0.24
Bone cells contain both inducible and constitutive prostaglandin G/H synthase (PGHS-2 and PGHS-1) and these are differentially regulated.
Positive_regulation (inducible) of PGHS-1
13) Confidence 0.42 Published 1997 Journal J. Bone Miner. Res. Section Abstract Doc Link 9258749 Disease Relevance 0.32 Pain Relevance 0.42
Enhanced in vitro percutaneous absorption and in vivo anti-inflammatory effect of a selective cyclooxygenase inhibitor using microemulsion.
Positive_regulation (Enhanced) of cyclooxygenase associated with inflammation
14) Confidence 0.41 Published 2005 Journal Drug Dev Ind Pharm Section Title Doc Link 16093206 Disease Relevance 0.64 Pain Relevance 0.51
Compounds were screened for cyclooxygenase inhibitory activity by the colorimetric COX (ovine) inhibitor screening assay, anti-inflammatory activity by the carrageenean induced rat paw oedema test and analgesic activity by the tail flick method.
Positive_regulation (screened) of cyclooxygenase in tail associated with pressure and volume under development, inflammation, analgesic and tail-flick
15) Confidence 0.40 Published 2008 Journal Acta Pharm Section Abstract Doc Link 19103568 Disease Relevance 0.19 Pain Relevance 0.19
We investigated the inhibitory effect of paracetamol and caffeine on lipopolysaccharide (LPS)-induced cyclooxygenase (COX)- and prostaglandin (PG)E(2)-synthesis in primary rat microglial cells and compared it with the effect of acetylsalicylic acid, salicylic acid, and dipyrone.
Positive_regulation (induced) of cyclooxygenase in microglial cells associated with aspirin and paracetamol
16) Confidence 0.39 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10963764 Disease Relevance 0 Pain Relevance 0.84
Upregulation of dorsal horn microglial cyclooxygenase-1 and neuronal cyclooxygenase-2 after thoracic deep muscle incisions in the rat.
Positive_regulation (Upregulation) of cyclooxygenase-1 in muscle associated with dorsal horn and cox1
17) Confidence 0.39 Published 2008 Journal Anesth. Analg. Section Title Doc Link 18349208 Disease Relevance 0.10 Pain Relevance 0.42
BACKGROUND: Plantar hindpaw incision produces hyperalgesia, transient upregulation of cyclooxygenase-2 (COX-2) and prolonged upregulation of cyclooxygenase-1 (COX-1) in rat lumbar spinal cord.
Positive_regulation (upregulation) of cyclooxygenase-1 in spinal cord associated with hyperalgesia and spinal cord
18) Confidence 0.39 Published 2008 Journal Anesth. Analg. Section Abstract Doc Link 18349208 Disease Relevance 0.10 Pain Relevance 0.32
Cyclooxygenase-2 is upregulated by inflammatory mediators and forms prostaglandins which intensify the inflammatory response.
Positive_regulation (upregulated) of Cyclooxygenase associated with inflammatory response and inflammatory mediators
19) Confidence 0.39 Published 2006 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 17218763 Disease Relevance 0.67 Pain Relevance 0.52
A cyclooxygenase enzyme induced in cultured cells by some non-steroid anti-inflammatory drugs is also more sensitive to inhibition by paracetamol than cyclooxygenase-2 induced by bacterial lipopolysaccharide.
Positive_regulation (induced) of cyclooxygenase associated with paracetamol, inflammation and cinod
20) Confidence 0.39 Published 2006 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 17218763 Disease Relevance 0.45 Pain Relevance 0.56

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