INT57720

From wiki-pain
Revision as of 03:26, 24 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.74
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 33
Total Number 33
Disease Relevance 20.24
Pain Relevance 6.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IGHG3)
Anatomy Link Frequency
plasma cells 3
bowel 2
B lymphocytes 2
lymph node 1
plasma 1
IGHG3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 21 100.00 Very High Very High Very High
cytokine 55 99.98 Very High Very High Very High
noradrenaline 3 99.98 Very High Very High Very High
agonist 6 99.24 Very High Very High Very High
nud 10 99.12 Very High Very High Very High
opiate 4 98.52 Very High Very High Very High
spastic colon 5 98.48 Very High Very High Very High
dexamethasone 40 97.84 Very High Very High Very High
fibrosis 171 97.08 Very High Very High Very High
Etanercept 112 94.28 High High
Disease Link Frequency Relevance Heat
Disease 278 100.00 Very High Very High Very High
Cv General 2 Under Development 44 100.00 Very High Very High Very High
Adhesions 31 100.00 Very High Very High Very High
Bacterial Respiratory Disease 3 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 3 100.00 Very High Very High Very High
Influenza Virus Infection 65 99.80 Very High Very High Very High
Systemic Sclerosis 62 99.80 Very High Very High Very High
Pancreatitis 742 99.70 Very High Very High Very High
Malaria 544 99.44 Very High Very High Very High
Dyspepsia 5 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Secondly, there is presently no reason to support for NRF to be limited to autoimmune pancreatitis and given the relevance of IgG4 in a vast array of other disorders, it is logical to assume NRF involvement therein.
Localization (relevance) of IgG4 associated with pancreatitis
1) Confidence 0.74 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.66 Pain Relevance 0
light chain (Bethyl Laboratories, Inc, A80115P) was used to detect IgG4 F(ab')2.


Localization (detect) of IgG4
2) Confidence 0.70 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.09 Pain Relevance 0
These observations suggest that important relationships exist between local IL-6 and IgA2, IgM, and IgG3 responses in human small intestinal luminal secretions.
Localization (secretions) of IgG3
3) Confidence 0.69 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9512143 Disease Relevance 0.21 Pain Relevance 0.10
IgA2 and IgG3 were the predominant IgA and IgG subclasses in luminal secretions in 19/20 (95%) and 20/20 (100%) subjects, respectively.
Localization (secretions) of IgG3
4) Confidence 0.69 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9512143 Disease Relevance 0.27 Pain Relevance 0.13
Twenty adult subjects with small intestinal bacterial overgrowth (N = 13), irritable bowel syndrome (N = 4), and nonulcer dyspepsia (N = 3) underwent endoscopic aspiration of secretions from the small intestinal mucosal surface for assessment of IL-6, IgA1, IgA2, IgM, IgG1, IgG2, IgG3, and IgG4 concentrations.
Localization (secretions) of IgG4 in bowel associated with spastic colon and nud
5) Confidence 0.65 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9512143 Disease Relevance 0.27 Pain Relevance 0.15
Twenty adult subjects with small intestinal bacterial overgrowth (N = 13), irritable bowel syndrome (N = 4), and nonulcer dyspepsia (N = 3) underwent endoscopic aspiration of secretions from the small intestinal mucosal surface for assessment of IL-6, IgA1, IgA2, IgM, IgG1, IgG2, IgG3, and IgG4 concentrations.
Localization (secretions) of IgG3 in bowel associated with spastic colon and nud
6) Confidence 0.65 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9512143 Disease Relevance 0.27 Pain Relevance 0.15
Following the report that the isotype distribution of antimalarial antibodies was a critical parameter of malaria immunity [46], various studies confirmed the increase of IgG3 with age, and hence with protection, for many malarial antigens including SIRBC extract, MSP1, MSP2, AMA1, RESA, GLURP, p126-SERP-SERA, EBA 175, TRAP, and Exp1 [28,38,39,45,52,55–62].
Localization (increase) of IgG3 associated with malaria
7) Confidence 0.61 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC2071934 Disease Relevance 0.32 Pain Relevance 0
With respect to the extracellular components, serum proteins, such as albumin, IgG3 and apolipoprotein B-100; as well as proteins displaying antibacterial properties, such as neutrophil defensin, cystatins B and S and Annexins A1 and A3, were found.
Localization (found) of IgG3 in neutrophil associated with bacterial respiratory disease and disorder of lipid metabolism
8) Confidence 0.58 Published 2010 Journal Journal of Proteome Research Section Body Doc Link PMC2950674 Disease Relevance 0.56 Pain Relevance 0
IgG was eluted with 10 mL of elution buffer, neutralized with 1M Tris pH 8.0, dialyzed against PBS, and concentrated to 0.4 mL (Amicon Ultra, 5,000 MWCO; Millipore).
Localization (neutralized) of IgG
9) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2845614 Disease Relevance 0.25 Pain Relevance 0
Merozoite pellets (40 µL), or alternatively normal or parasitized red cell pellets, were incubated with 10 µL of test or control sera or IgG for at least 30 min at 37°C.
Localization (sera) of IgG
10) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2845614 Disease Relevance 0 Pain Relevance 0
The cytophilic IgG (IgG1 and IgG3) and the non-cytophilic IgG (IgG2 and IgG4) responses to MSP3-LSP are presented in Figure 3.
Localization (presented) of IgG3
11) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2764341 Disease Relevance 0.26 Pain Relevance 0
However, little is known about factors that induce class switching and how the relative proportion of IgG1/IgG3 to different malaria antigens is established.
Localization (proportion) of IgG3 associated with malaria
12) Confidence 0.35 Published 2009 Journal Parasite Immunology Section Body Doc Link PMC2759986 Disease Relevance 0.52 Pain Relevance 0
IgA2 and IgG3 were the predominant IgA and IgG subclasses in luminal secretions in 19/20 (95%) and 20/20 (100%) subjects, respectively.
Localization (secretions) of IgG
13) Confidence 0.30 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9512143 Disease Relevance 0.26 Pain Relevance 0.13
For determination of IgG subclasses (IgG1, IgG2, IgG3 and IgG4), plasma samples diluted 1:50 were added in duplicate and incubated for one hour at room temperature.
Localization (determination) of IgG3 in plasma
14) Confidence 0.23 Published 2005 Journal Malar J Section Body Doc Link PMC1262760 Disease Relevance 0.05 Pain Relevance 0
The monoclonal IgG subclasses were diluted 1:2000 for IgG1, 1:3000 for IgG2, IgG3 and IgG4 in dilution buffer and incubated for one hour at room temperature.
Localization (1:3000) of IgG3
15) Confidence 0.23 Published 2005 Journal Malar J Section Body Doc Link PMC1262760 Disease Relevance 0.06 Pain Relevance 0
The following monoclonal mouse anti-human subclasses were used: clone NL16 for IgG1 (Sky lab), clone NP6002 for IgG2 (Sigma), clone ZG4 for IgG3 (Sky lab) and clone RJ4 for IgG4 (Sky lab).
Localization (used) of IgG3
16) Confidence 0.23 Published 2005 Journal Malar J Section Body Doc Link PMC1262760 Disease Relevance 0.05 Pain Relevance 0
M3G and M6G are formed by morphine glucuronidation, mainly in the liver, and are excreted by the kidneys.
Localization (excreted) of M3G in liver associated with morphine
17) Confidence 0.09 Published 2003 Journal J Pain Symptom Manage Section Abstract Doc Link 12565191 Disease Relevance 0.07 Pain Relevance 1.15
Anti-ICC-1132, anti-HBc and anti-(T1B)4 IgG1 and IgG3 subtypes, typical of TH1-type immune responses, developed preferentially over IgG2 and IgG4 subtypes (P?
Localization (typical) of IgG3
18) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2216688 Disease Relevance 0.30 Pain Relevance 0
We have examined the opiate binding characteristics, effects on cAMP formation and [3H]noradrenaline release of morphine, morphine-6 (M6G) and -3 (M3G)-glucuronides, and fentanyl in SH-SY5Y human neuroblastoma cells.
Localization (release) of M3G in SH-SY5Y associated with neuroblastoma, noradrenaline, opiate and morphine
19) Confidence 0.07 Published 1993 Journal Biochem. Pharmacol. Section Abstract Doc Link 8216364 Disease Relevance 0.10 Pain Relevance 0.87
Dense infiltration of IgG4-positive plasma cells was detected in the pancreas (a), periportal area of the liver (b), salivary gland (c), lymph node (d), and associated retroperitoneal fibrous mass (e)

Diagnostic criteria and differential diagnosis

Localization (infiltration) of IgG4 in lymph node
20) Confidence 0.06 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780632 Disease Relevance 1.01 Pain Relevance 0.15

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox