INT5780

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Context Info
Confidence 0.62
First Reported 1986
Last Reported 2010
Negated 16
Speculated 39
Reported most in Abstract
Documents 90
Total Number 129
Disease Relevance 59.52
Pain Relevance 85.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) aging (Calca) extracellular region (Calca)
nucleus (Calca) intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
neurons 24
dorsal root ganglion 20
nerve 16
spinal cord 14
spinal 13
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 1569 100.00 Very High Very High Very High
Nerve growth factor 363 100.00 Very High Very High Very High
Pain 361 100.00 Very High Very High Very High
dorsal root ganglion 277 100.00 Very High Very High Very High
amygdala 263 100.00 Very High Very High Very High
qutenza 202 100.00 Very High Very High Very High
Inflammation 182 100.00 Very High Very High Very High
substance P 175 100.00 Very High Very High Very High
Neuropeptide 137 100.00 Very High Very High Very High
Arthritis 106 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 494 100.00 Very High Very High Very High
Pain 332 100.00 Very High Very High Very High
Arthritis 180 100.00 Very High Very High Very High
INFLAMMATION 167 100.00 Very High Very High Very High
Cancer 40 100.00 Very High Very High Very High
Necrosis 17 100.00 Very High Very High Very High
Heat Stress Disorders 6 99.82 Very High Very High Very High
Neuropathic Pain 49 99.78 Very High Very High Very High
Headache 58 99.68 Very High Very High Very High
Increased Venous Pressure Under Development 18 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The purpose of this study is to clarify the effects of 17beta-estradiol and the Japanese herbal medicine Keishi-bukuryo-gan on the release and synthesis of calcitonin gene-related peptide (CGRP) in ovariectomized (OVX) rats.
Regulation (effects) of Gene_expression (synthesis) of calcitonin gene-related peptide associated with calcitonin gene-related peptide
1) Confidence 0.62 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14501156 Disease Relevance 0 Pain Relevance 0.45
These hormones may regulate the synthesis and receptor expression of calcitonin gene-related peptide (CGRP), which mediates neurogenic dural vasodilatation and is implicated in migraine pathogenesis.
Spec (may) Regulation (regulate) of Gene_expression (expression) of CGRP associated with migraine, increased venous pressure under development and calcitonin gene-related peptide
2) Confidence 0.62 Published 2007 Journal Headache Section Abstract Doc Link 17300362 Disease Relevance 0.37 Pain Relevance 0.32
The aim of this study was to investigate the possible influence of low-energy ESWT on the expression of the transmitters substance P (SP) and calcitonin gene-related peptide (CGRP) in the lumbar spinal cord of the rat.
Spec (possible) Regulation (influence) of Gene_expression (expression) of CGRP in spinal cord associated with spinal cord, calcitonin gene-related peptide and substance p
3) Confidence 0.62 Published 2002 Journal J Orthop Sci Section Abstract Doc Link 11819140 Disease Relevance 0.47 Pain Relevance 0.69
In the present study, we tested the hypothesis that gonadal steroids influence CGRP expression in SNB motoneurons through their effects on the bulbocavernosus and levator ani muscles.
Regulation (influence) of Gene_expression (expression) of CGRP in levator ani associated with calcitonin gene-related peptide
4) Confidence 0.62 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1315918 Disease Relevance 0.08 Pain Relevance 0.41
Since both the SNB motoneurons and their target muscles, the bulbocavernosus and the levator ani, are steroid sensitive, gonadal steroids may act at either site to regulate CGRP expression.
Regulation (regulate) of Gene_expression (expression) of CGRP in gonadal associated with calcitonin gene-related peptide
5) Confidence 0.62 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1315918 Disease Relevance 0.07 Pain Relevance 0.37
Long-term immobilization by casting may induce phenotypic changes in CGRP expression both in DRG and spinal deep layers, and these changes are partly responsible for pathological pain states in immobilized side.
Regulation (changes) of Gene_expression (expression) of CGRP in DRG associated with pain, dorsal root ganglion and calcitonin gene-related peptide
6) Confidence 0.62 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19429062 Disease Relevance 0.54 Pain Relevance 0.79
Additionally, we examined the effect of the glucocorticoid drug budesonide on arthritis-induced changes of calcitonin gene-related peptide expression and constitutive calcitonin gene-related peptide expression.
Regulation (changes) of Gene_expression (expression) of calcitonin associated with calcitonin gene-related peptide and arthritis
7) Confidence 0.62 Published 1999 Journal Neuroscience Section Abstract Doc Link 10465459 Disease Relevance 1.02 Pain Relevance 0.65
Image analysis of calcitonin gene-related peptide immunoreactivity revealed that changes in calcitonin gene-related peptide expression were due to alterations in calcitonin gene-related peptide expression levels rather than to de novo synthesis or changes in the numbers of calcitonin gene-related peptide expressing neurons.
Regulation (changes) of Gene_expression (expression) of calcitonin in neurons associated with calcitonin gene-related peptide
8) Confidence 0.62 Published 1999 Journal Neuroscience Section Abstract Doc Link 10465459 Disease Relevance 0.91 Pain Relevance 0.74
Additionally, we examined the effect of the glucocorticoid drug budesonide on arthritis-induced changes of calcitonin gene-related peptide expression and constitutive calcitonin gene-related peptide expression.
Regulation (changes) of Gene_expression (expression) of calcitonin associated with calcitonin gene-related peptide and arthritis
9) Confidence 0.62 Published 1999 Journal Neuroscience Section Abstract Doc Link 10465459 Disease Relevance 0.99 Pain Relevance 0.64
Calcitonin gene-related peptide gene expression in collagen-induced arthritis is differentially regulated in primary afferents and motoneurons: influence of glucocorticoids.
Regulation (regulated) of Gene_expression (expression) of Calcitonin in motoneurons associated with arthritis and calcitonin gene-related peptide
10) Confidence 0.62 Published 1999 Journal Neuroscience Section Title Doc Link 10465459 Disease Relevance 0.94 Pain Relevance 0.63
Image analysis of calcitonin gene-related peptide immunoreactivity revealed that changes in calcitonin gene-related peptide expression were due to alterations in calcitonin gene-related peptide expression levels rather than to de novo synthesis or changes in the numbers of calcitonin gene-related peptide expressing neurons.
Regulation (alterations) of Gene_expression (expression) of calcitonin in neurons associated with calcitonin gene-related peptide
11) Confidence 0.62 Published 1999 Journal Neuroscience Section Abstract Doc Link 10465459 Disease Relevance 0.85 Pain Relevance 0.69
The opposite regulation of calcitonin gene-related peptide gene expression in primary sensory and spinal somatomotor pathways in collagen-induced arthritis suggests that calcitonin gene-related peptide plays a specific role in both chronic inflammatory pain and arthritis-induced motor dysfunction.
Regulation (regulation) of Gene_expression (expression) of calcitonin in spinal associated with ipn, arthritis and calcitonin gene-related peptide
12) Confidence 0.62 Published 1999 Journal Neuroscience Section Abstract Doc Link 10465459 Disease Relevance 0.88 Pain Relevance 0.93
In this paper, we used collagen II-induced arthritis in the rat as a model to investigate the influence of chronic arthritic pain on calcitonin gene-related peptide gene expression in sensory and motor pathways.
Spec (investigate) Regulation (influence) of Gene_expression (expression) of calcitonin associated with pain, calcitonin gene-related peptide and arthritis
13) Confidence 0.62 Published 1999 Journal Neuroscience Section Abstract Doc Link 10465459 Disease Relevance 0.84 Pain Relevance 0.61
The changes in calcitonin gene-related peptide expression in motoneurons correlated with the severity of arthritis in the ipsilateral hind paw.
Regulation (changes) of Gene_expression (expression) of calcitonin in motoneurons associated with arthritis and calcitonin gene-related peptide
14) Confidence 0.62 Published 1999 Journal Neuroscience Section Abstract Doc Link 10465459 Disease Relevance 0.97 Pain Relevance 0.83
Key signal transduction pathways were tested pharmacologically for their role in CGRP expression after depolarization; the addition of the CaM kinase inhibitor KN-62 reduced the proportion of CGRP-IR neurons to basal levels.
Regulation (role) of Gene_expression (expression) of CGRP in neurons associated with calcitonin gene-related peptide
15) Confidence 0.62 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9801368 Disease Relevance 0.34 Pain Relevance 0.98
The factors that regulate the developmental expression of CGRP are poorly understood.
Regulation (regulate) of Gene_expression (expression) of CGRP associated with calcitonin gene-related peptide
16) Confidence 0.62 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9801368 Disease Relevance 0.57 Pain Relevance 0.88
Eletriptan also affected expression of CGRP in perikarya of trigeminal ganglion cells, insofar as the number of small nerve cells exhibiting a compact CGRP immunoreaction was decreased to one quarter of the original value.
Regulation (affected) of Gene_expression (expression) of CGRP in trigeminal ganglion associated with ganglion cysts, trigeminal ganglion and calcitonin gene-related peptide
17) Confidence 0.62 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 11069595 Disease Relevance 0.54 Pain Relevance 0.74
Direct application of the TNF-alpha inhibitor, etanercept, does not affect CGRP expression and phenotypic change of DRG neurons following application of nucleus pulposus onto injured sciatic nerves in rats.
Neg (not) Regulation (affect) of Gene_expression (expression) of CGRP in neurons associated with neuralgia, sciatic nerve and etanercept
18) Confidence 0.62 Published 2008 Journal Spine Section Title Doc Link 18824950 Disease Relevance 0 Pain Relevance 0.39
These studies examined changes in the expression of calcitonin gene-related peptide (CGRP) and substance P (SP) in lumbosacral (L6-S1) micturition reflex pathways, following chronic cystitis induced by cyclophosphamide (CYP).
Spec (examined) Regulation (changes) of Gene_expression (expression) of calcitonin gene-related peptide associated with cystitis, overactive bladder, substance p and calcitonin gene-related peptide
19) Confidence 0.61 Published 2001 Journal J. Chem. Neuroanat. Section Abstract Doc Link 11312054 Disease Relevance 0.39 Pain Relevance 0.54
Effects of the peripherally selective kappa-opioid asimadoline, on substance P and CGRP mRNA expression in chronic arthritis of the rat.
Regulation (Effects) of Gene_expression (expression) of CGRP mRNA associated with opioid, arthritis and substance p
20) Confidence 0.61 Published 2000 Journal Neuropeptides Section Title Doc Link 11021980 Disease Relevance 0.27 Pain Relevance 0.91

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