INT57875

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Context Info
Confidence 0.49
First Reported 1993
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.74
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr1) intracellular (Egr1) DNA binding (Egr1)
transcription factor binding (Egr1) cytoplasm (Egr1)
Anatomy Link Frequency
blood 2
liver 2
striatum 2
vein 2
salivary gland 2
Egr1 (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 8 99.84 Very High Very High Very High
Nerve growth factor 50 97.76 Very High Very High Very High
Hippocampus 25 95.00 High High
fluoxetine 2 93.88 High High
Desipramine 1 91.68 High High
cytokine 11 87.36 High High
Dopamine 6 83.52 Quite High
monoamine 1 77.88 Quite High
Serotonin 2 75.00 Quite High
agonist 1 58.32 Quite High
Disease Link Frequency Relevance Heat
Melanoma 102 98.12 Very High Very High Very High
Cancer 129 98.00 Very High Very High Very High
Lung Cancer 32 94.24 High High
Metastasis 4 87.56 High High
Salivary Gland Disease 36 83.08 Quite High
Targeted Disruption 28 54.72 Quite High
Occupational Lung Diseases 54 54.20 Quite High
Disease 65 50.00 Quite Low
Depression 1 44.76 Quite Low
Idiopathic Pulmonary Fibrosis 22 40.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a similar vein, BDNF and zif268 mRNA expression were reported in the entorhinal and prefrontal cortices after object sampling, while in this experiment reactivation 9 days after training induced zif268 in entorhinal and somatosensory cortices and upon reactivation 21 days after training, BDNF and not zif268 was expressed in hippocampus and entorhinal and somatosensory cortices (Romero-Granados et al., 2010).
Positive_regulation (reactivation) of Positive_regulation (induced) of zif268 in vein associated with hippocampus
1) Confidence 0.49 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2992451 Disease Relevance 0 Pain Relevance 0.05
Interestingly, the induction of immediate early genes c-Fos and Egr-1 which can function as sensors for duration of Erk1/2 signaling [20] was reduced in c-Met mutant mice, particularly at the later time points of liver regeneration (Figure S3).
Positive_regulation (function) of Positive_regulation (induction) of Egr-1 in liver
2) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0.05 Pain Relevance 0
Therefore, it is reasonable to propose that NGF secreted by melanoma tumor was transferred through blood and bound to its cognate receptors in the salivary gland, ultimately resulting in the stimulation of multiple TFs expression including Egr-1 (Fig. 6).
Positive_regulation (resulting) of Positive_regulation (stimulation) of Egr-1 in blood associated with nerve growth factor, cancer and melanoma
3) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691577 Disease Relevance 1.49 Pain Relevance 0.39
We therefore hypothesize that NGF is secreted into the circulation by the melanoma, circulates to the salivary gland where it activates the receptor-mediated signaling cascade leading to Egr-1 upregulation and induction of specific gene transcription and protein translation.
Positive_regulation (leading) of Positive_regulation (upregulation) of Egr-1 in salivary gland associated with nerve growth factor and melanoma
4) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691577 Disease Relevance 1.09 Pain Relevance 0.37
Furthermore, selective denervation of 5-HT projections by p-chloroamphetamine treatment attenuated the increase in zif268 and c-fos expression induced by cocaine in the striatum.
Positive_regulation (increase) of Positive_regulation (induced) of zif268 in striatum associated with cocaine
5) Confidence 0.43 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8229780 Disease Relevance 0 Pain Relevance 0.86
At 28 d, 38 of the 40 transcripts were increased (only CHUK and EGR1 were not significantly increased).
Positive_regulation (increased) of Neg (not) Positive_regulation (increased) of EGR1
6) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682759 Disease Relevance 0.11 Pain Relevance 0.09

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