INT57960

Context Info Confidence 0.24 First Reported 1993 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.26 Pain Relevance 0.61

ligase activity (Gss)

Anatomy Link Frequency liver 1 Gss (Mus musculus)

Pain Link Frequency Relevance Heat Paracetamol 7 99.30

Disease Link Frequency Relevance Heat Hepatotoxicity 4 98.32 Cancer 1 49.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A prolonged paracetamol challenge (0.6% diet for 10 days) elevated liver cytosolic GSH-S-transferase activity (GST) two-fold and decreased liver GSH to 46% of control values.

Positive_regulation (elevated) of GSH-S-transferase activity in liver associated with paracetamol

1) Confidence 0.24 Published 1993 Journal Xenobiotica Section Abstract Doc Link 8237062 Disease Relevance 0 Pain Relevance 0.45

In addition, AF prevented hepatic glutathione (GSH) depletion by APAP, and hepatic GSH levels and GSH S-transferase activities were up-regulated by AF.

Positive_regulation (up-regulated) of GSH S-transferase

2) Confidence 0.11 Published 2009 Journal J Med Food Section Abstract Doc Link 19459732 Disease Relevance 0.26 Pain Relevance 0.16

General Comments

This test has worked.