INT58211

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Context Info
Confidence 0.57
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 0.62
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (FURIN) peptidase activity (FURIN) extracellular space (FURIN)
aging (FURIN) Golgi apparatus (FURIN) plasma membrane (FURIN)
Anatomy Link Frequency
pituitary 1
FURIN (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 16 99.74 Very High Very High Very High
melanocortin 1 receptor 1 96.72 Very High Very High Very High
Arthritis 87 89.36 High High
alcohol 73 86.24 High High
Pain 22 76.20 Quite High
antagonist 20 75.12 Quite High
Opioid 2 60.24 Quite High
addiction 42 42.16 Quite Low
cytokine 5 39.04 Quite Low
agonist 17 33.40 Quite Low
Disease Link Frequency Relevance Heat
Pox Virus Infection 2 99.44 Very High Very High Very High
Arthritis 87 89.36 High High
Pain 16 76.20 Quite High
Recurrence 14 59.84 Quite High
Vomiting 4 59.12 Quite High
Targeted Disruption 17 49.44 Quite Low
Adhesions 1 43.12 Quite Low
Substance Abuse 107 42.16 Quite Low
INFLAMMATION 14 27.48 Quite Low
Acute Erythroblastic Leukemia 2 19.92 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results of this study did not reveal notable differences in the factors that motivated completers and noncompleters to participate in PACE classes.
Gene_expression (classes) of PACE
1) Confidence 0.57 Published 2005 Journal Prev Chronic Dis Section Body Doc Link PMC1364520 Disease Relevance 0.17 Pain Relevance 0.12
The ability to exercise at one's own pace was one of the most frequently reported themes and was referred to by both the completers and the noncompleters:

Themes related to moderating factors (barriers)

Gene_expression (one) of pace
2) Confidence 0.57 Published 2005 Journal Prev Chronic Dis Section Body Doc Link PMC1364520 Disease Relevance 0.19 Pain Relevance 0.10
Recombinant vaccinia virus vectors were used to coexpress mouse prohormone convertase 1 (mPC1), mPC2, or human furin together with human proenkephalin in GH4C1 cells (rat pituitary somatomammotrophs) to examine the proteolytic processing of proenkephalin by these enzymes.
Gene_expression (coexpress) of furin in pituitary associated with pox virus infection
3) Confidence 0.32 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8262946 Disease Relevance 0.10 Pain Relevance 0.11
Differential processing of proenkephalin by prohormone convertases 1(3) and 2 and furin.
Gene_expression (processing) of furin associated with enkephalin
4) Confidence 0.28 Published 1993 Journal J. Biol. Chem. Section Title Doc Link 8262946 Disease Relevance 0.10 Pain Relevance 0.63
Subsequently, several prohormone convertases (PC1/3, PC2, and furin) permit sequential formation of octanoylated Ser3 proghrelin 1–94 and octanoylated Ser3 ghrelin 1–28 [496, 649, 650].
Gene_expression (/) of furin
5) Confidence 0.12 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0 Pain Relevance 0
The Parent and Child Enrichment Program (PACE) program in Harlem began in 1990 as a result of these grants.
Gene_expression (program) of PACE
6) Confidence 0.06 Published 2004 Journal Harm Reduct J Section Body Doc Link PMC419718 Disease Relevance 0.06 Pain Relevance 0.04
Among the prohormone convertases (PCs) tested, only PC2, its chaperone 7B2, and furin convertase but not PC1 and paired basic amino acid cleaving enzyme 4 gene were detected.
Gene_expression (detected) of furin convertase
7) Confidence 0.05 Published 2005 Journal Endocrinology Section Abstract Doc Link 16081629 Disease Relevance 0 Pain Relevance 0.13

General Comments

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