INT58311

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Context Info
Confidence 0.54
First Reported 1994
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.06
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EGF) extracellular space (EGF) extracellular region (EGF)
plasma membrane (EGF)
EGF (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 2 100.00 Very High Very High Very High
substance P 1 100.00 Very High Very High Very High
sodium channel 82 99.80 Very High Very High Very High
Neuropeptide 2 99.80 Very High Very High Very High
cINOD 3 98.84 Very High Very High Very High
Opioid 2 87.16 High High
Dopamine 63 73.64 Quite High
Nerve growth factor 6 64.48 Quite High
Central nervous system 8 39.28 Quite Low
Kinase C 1 28.48 Quite Low
Disease Link Frequency Relevance Heat
Natriuresis 1 99.92 Very High Very High Very High
INFLAMMATION 1 98.12 Very High Very High Very High
Reprotox - General 1 82 96.36 Very High Very High Very High
Stress 3 94.16 High High
Galactorrhea 124 92.32 High High
Metastasis 3 72.56 Quite High
Anaplastic Astrocytoma 1 60.40 Quite High
Hepatotoxicity 1 43.28 Quite Low
Chronic Renal Failure 2 41.60 Quite Low
Central Nervous System Disease 1 39.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of indomethacin on the secretion of human salivary epidermal growth factor.
Regulation (effect) of Localization (secretion) of epidermal growth factor
1) Confidence 0.54 Published 1994 Journal Am. J. Gastroenterol. Section Title Doc Link 8273807 Disease Relevance 0.10 Pain Relevance 0.29
If VGSC activity controlled the release of EGF (eg via vesicular trafficking), it could lead to the following positive feed-back: VGSC activity ?
Regulation (controlled) of Localization (release) of EGF associated with sodium channel
2) Confidence 0.25 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2211503 Disease Relevance 0.62 Pain Relevance 0.60
A number of other neurotrasmitters and neuropeptides can also modulate prolactin secretion, among which galanin, endothelin, TGFbeta1, angiotensin, somatostatin, substance P, neurotensin, calcitonin, EGF, natriuretic atrial peptide, bombesin, colecistokinine, acetylcholine, vasopressin (Figure 1).
Regulation (modulate) of Localization (secretion) of EGF associated with natriuresis, somatostatin, neuropeptide and substance p
3) Confidence 0.19 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0.34 Pain Relevance 0.27

General Comments

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