INT5840

Context Info Confidence 0.71 First Reported 1992 Last Reported 2010 Negated 2 Speculated 0 Reported most in Abstract Documents 26 Total Number 26 Disease Relevance 18.18 Pain Relevance 10.41

structural molecule activity (Gfap) extracellular matrix organization (Gfap) cytoplasm (Gfap)

Anatomy Link Frequency retina 2 eyes 2 Spinal 2 neuronal 2 astrocytes 2 Gfap (Rattus norvegicus)

Pain Link Frequency Relevance Heat depression 4 99.78 Hippocampus 21 99.40 ischemia 508 99.38 Neuropathic pain 34 99.20 midbrain 7 99.16 Spinal cord 6 98.40 tetrodotoxin 4 96.60 Inflammation 34 96.28 allodynia 10 94.76 Central nervous system 8 94.68

Disease Link Frequency Relevance Heat Depression 4 99.78 Convulsion 36 99.64 Transient Ischemic Attack 7 99.38 Neuropathic Pain 44 99.20 Injury 147 98.88 Cv Unclassified Under Development 366 98.48 Epilepsy 12 97.12 INFLAMMATION 37 96.28 Retina Disease 145 96.24 Infection 29 92.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

GeneChips, RT-PCR and Western blotting revealed the select up-regulation in translation and transcription of glial fibrillary acidic protein (GFAP) and Vimentin in rats with Persistent Disability.

Transcription (transcription) of GFAP

1) Confidence 0.71 Published 2010 Journal Neuroscience Section Abstract Doc Link 20109535 Disease Relevance 1.31 Pain Relevance 0.97

Spinal lumbar mRNA levels of glial fibrillary acidic protein (GFAP), integrin alpha M (ITGAM), toll-like receptor 4 (TLR4) and cluster determinant 14 (CD14) were assayed using real-time reverse transcription polymerase chain reaction (RT-PCR) at 4 h, 1, 4, 7, 14 and 28 days post surgery.

Transcription (levels) of GFAP in Spinal

2) Confidence 0.70 Published 2004 Journal Neurochem. Int. Section Abstract Doc Link 15145554 Disease Relevance 0.41 Pain Relevance 0.32

Spinal lumbar mRNA levels of glial fibrillary acidic protein (GFAP), integrin alpha M (ITGAM), toll-like receptor 4 (TLR4) and cluster determinant 14 (CD14) were assayed using real-time reverse transcription polymerase chain reaction (RT-PCR) at 4 h, 1, 4, 7, 14 and 28 days post surgery.

Transcription (levels) of glial fibrillary acidic protein in Spinal

3) Confidence 0.70 Published 2004 Journal Neurochem. Int. Section Abstract Doc Link 15145554 Disease Relevance 0.41 Pain Relevance 0.32

For example, mRNA levels of glial fibrilary acidic protein (GFAP) and Aquaporin 4 (AQP4) significantly increased in CNP rats.

Transcription (levels) of GFAP associated with neuropathic pain

4) Confidence 0.70 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16219025 Disease Relevance 1.97 Pain Relevance 1.58

For example, mRNA levels of glial fibrilary acidic protein (GFAP) and Aquaporin 4 (AQP4) significantly increased in CNP rats.

Transcription (levels) of glial fibrilary acidic protein associated with neuropathic pain

5) Confidence 0.70 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16219025 Disease Relevance 1.97 Pain Relevance 1.58

To assess the reactivity of astrocytes in transient cerebral ischemia of the gerbil, we studied the levels of glial fibrillary acidic protein (GFAP) and its mRNA.

Transcription (levels) of GFAP in astrocytes associated with transient ischemic attack and ischemia

6) Confidence 0.69 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1317493 Disease Relevance 0.17 Pain Relevance 0.25

To assess the reactivity of astrocytes in transient cerebral ischemia of the gerbil, we studied the levels of glial fibrillary acidic protein (GFAP) and its mRNA.

Transcription (levels) of glial fibrillary acidic protein in astrocytes associated with transient ischemic attack and ischemia

7) Confidence 0.69 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1317493 Disease Relevance 0.17 Pain Relevance 0.25

With the exception of Gap43, the levels of Cltc, Gfap, Tau, stathmin, and alpha-tubulin proteins were found to be in good agreement with those from mRNA quantification.

Neg (exception) Transcription (exception) of Gfap

8) Confidence 0.67 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 15199374 Disease Relevance 0.09 Pain Relevance 0.38

Immunostaining for Iba-1 followed the same procedures described for GFAP with the exception that anti-Iba-1 (1: 500 WAKO Chemicals, Richmond, USA) was the primary antibody.

Neg (exception) Transcription (described) of GFAP

9) Confidence 0.66 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2989304 Disease Relevance 0 Pain Relevance 0

GeneChips, RT-PCR and Western blotting revealed the select up-regulation in translation and transcription of glial fibrillary acidic protein (GFAP) and Vimentin in rats with Persistent Disability.

Transcription (transcription) of glial fibrillary acidic protein

10) Confidence 0.53 Published 2010 Journal Neuroscience Section Abstract Doc Link 20109535 Disease Relevance 1.31 Pain Relevance 0.97

However, when kindled seizures are not induced, levels of GFAP mRNA return to near control levels within a few days.

Transcription (levels) of GFAP associated with convulsion

11) Confidence 0.53 Published 1992 Journal Epilepsy Res. Suppl. Section Abstract Doc Link 1334663 Disease Relevance 1.07 Pain Relevance 0.12

If seizures are induced repetitively (every other day for many days), levels of GFAP mRNA remain elevated.

Transcription (levels) of GFAP associated with convulsion

12) Confidence 0.53 Published 1992 Journal Epilepsy Res. Suppl. Section Abstract Doc Link 1334663 Disease Relevance 1.06 Pain Relevance 0.11

The increases in GFAP mRNA levels are not in response to decreases in neuronal activity (as a result of postictal depression), because GFAP mRNA levels are unaffected when neuronal activity is decreased by blocking afferent drive (with tetrodotoxin).

Transcription (levels) of GFAP in neuronal associated with tetrodotoxin and depression

13) Confidence 0.53 Published 1992 Journal Epilepsy Res. Suppl. Section Abstract Doc Link 1334663 Disease Relevance 1.07 Pain Relevance 0.14

The increases in GFAP mRNA levels are not in response to decreases in neuronal activity (as a result of postictal depression), because GFAP mRNA levels are unaffected when neuronal activity is decreased by blocking afferent drive (with tetrodotoxin).

Transcription (levels) of GFAP in neuronal associated with tetrodotoxin and depression

14) Confidence 0.53 Published 1992 Journal Epilepsy Res. Suppl. Section Abstract Doc Link 1334663 Disease Relevance 1.06 Pain Relevance 0.15

An examination of the specific regions of the brain revealed an increase in GFAP mRNA associated with the forebrain, midbrain, hippocampus and striatum.

Transcription (associated) of GFAP in hippocampus associated with hippocampus and midbrain

15) Confidence 0.51 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1317493 Disease Relevance 0.28 Pain Relevance 0.29

GFAP mRNA in the non-ischemic cerebellum however, remained expressed at constitutively low levels.

Transcription (expressed) of GFAP in cerebellum

16) Confidence 0.51 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1317493 Disease Relevance 0.35 Pain Relevance 0.29

No up-regulation of GFAP was detected in PVG rats in any compartment (Table 1).

Transcription (detected) of GFAP

17) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 0.36 Pain Relevance 0

In the present study, GFAP mRNA levels increased in the retinas subjected to ischemia-reperfusion, indicating that an insult that triggers a molecular response had indeed taken place.

Transcription (levels) of GFAP in retinas associated with ischemia

18) Confidence 0.46 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838742 Disease Relevance 1.09 Pain Relevance 0.35

Relative levels of GFAP mRNA and peptide were highest in the lumbar spinal cord 4-10 d following T cell transfer and significant GFAP elevations were still present after three weeks.

Transcription (levels) of GFAP mRNA in T cell associated with spinal cord

19) Confidence 0.40 Published 1995 Journal Brain Pathol. Section Abstract Doc Link 7539325 Disease Relevance 0.47 Pain Relevance 0.49

GFAP mRNA expression levels were higher in the neuroretinas from ischemia-reperfusion eyes than from sham-operated eyes and increased gradually with increasing duration of reperfusion (Figure 3).

Transcription (expression) of GFAP in eyes associated with ischemia

20) Confidence 0.34 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838742 Disease Relevance 0.37 Pain Relevance 0.19

General Comments

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