INT58433

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Context Info
Confidence 0.59
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 2.77
Pain Relevance 3.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (F2r) signal transducer activity (F2r)
Anatomy Link Frequency
plasma 1
spine 1
bladder 1
platelet 1
skin 1
F2r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 10 99.98 Very High Very High Very High
qutenza 11 99.84 Very High Very High Very High
antagonist 16 99.60 Very High Very High Very High
Angina 5 98.88 Very High Very High Very High
tetrodotoxin 3 96.84 Very High Very High Very High
agonist 14 96.24 Very High Very High Very High
Spinal cord 1 85.52 High High
substantia gelatinosa 4 84.16 Quite High
Nucleus accumbens 2 75.00 Quite High
Substantia gelatinosa neuron 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Thrombosis 9 99.44 Very High Very High Very High
Cv General 3 Under Development 11 98.88 Very High Very High Very High
Urological Neuroanatomy 5 97.44 Very High Very High Very High
Hemorrhage 54 96.52 Very High Very High Very High
Myocardial Infarction 2 95.32 Very High Very High Very High
Stroke 7 94.16 High High
Cardiovascular Disease 2 93.68 High High
Acute Coronary Syndrome 53 93.44 High High
Death 5 90.48 High High
Coronary Artery Disease 47 76.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of thrombin receptor (PAR-1) is a promising therapeutic approach for the treatment of various cardiovascular disorders such as unstable angina, acute myocardial infarction, stroke, and restenosis.
Negative_regulation (Inhibition) of thrombin associated with angina, cardiovascular disease, stroke and myocardial infarction
1) Confidence 0.59 Published 2003 Journal Curr Top Med Chem Section Abstract Doc Link 12769712 Disease Relevance 0.45 Pain Relevance 0.24
Inhibition of thrombin receptor (PAR-1) is a promising therapeutic approach for the treatment of various cardiovascular disorders such as unstable angina, acute myocardial infarction, stroke, and restenosis.
Negative_regulation (Inhibition) of PAR-1 associated with angina, cardiovascular disease, stroke and myocardial infarction
2) Confidence 0.59 Published 2003 Journal Curr Top Med Chem Section Abstract Doc Link 12769712 Disease Relevance 0.45 Pain Relevance 0.25
Although hirulog, a specific, direct inhibitor of thrombin, can prevent thrombosis in unstable angina and angioplasty without inducing excessive bleeding, it has not been used in a surgical setting.
Negative_regulation (inhibitor) of thrombin associated with angina, hemorrhage and thrombosis
3) Confidence 0.54 Published 1996 Journal J. Surg. Res. Section Abstract Doc Link 8592407 Disease Relevance 0.29 Pain Relevance 0.10
The PAR-1 peptide action was inhibited by PAR-1 antagonist YFLLRNP-OH.
Negative_regulation (inhibited) of PAR-1 peptide associated with antagonist
4) Confidence 0.42 Published 2009 Journal J. Neurophysiol. Section Abstract Doc Link 19420120 Disease Relevance 0 Pain Relevance 0.51
Composite images showed that PAR1 and MIF immunostaining was limited to basal and occasional intermediate cells (Fig. 2I).
Negative_regulation (limited) of PAR1
5) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0 Pain Relevance 0
Consistently, formaldehyde fixation abolished PAR1 immunostaining in rat bladder when compared to acetone fixation.
Negative_regulation (abolished) of PAR1 in bladder
6) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0 Pain Relevance 0
However, only SA morphine decreased spine density in the hippocampal formation and only EA morphine decreased spine density in Par1.
Negative_regulation (decreased) of Par1 in spine associated with morphine
7) Confidence 0.39 Published 2002 Journal Synapse Section Abstract Doc Link 12373743 Disease Relevance 0.39 Pain Relevance 0.95
Effects of DX-9065a ((+)-2S-2-[4-[[(3S)-1-acetimidoyl-3-pyrrolidinyl]oxy]phenyl]-3-[7-amidino-2-naphthyl]propanoic acid hydrochloride pentahydrate), a dibasic propanoic acid and an inhibitor of factor Xa, were compared with those of argatroban, a low molecular weight thrombin inhibitor, on the ellagic acid-induced plantar skin thrombosis in the rats treated with tetrodotoxin and N(omega)-nitro-L-arginine.
Negative_regulation (inhibitor) of thrombin in skin associated with tetrodotoxin and thrombosis
8) Confidence 0.32 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 12719661 Disease Relevance 0.32 Pain Relevance 0.17
The prothrombin and partial thromboplastin time and the plasma levels of fibrinogen and antithrombin III remained unchanged by capsaicin or L-NAME, whereas the thrombin time was reduced in capsaicin-pretreated rats.
Negative_regulation (reduced) of thrombin in plasma associated with qutenza
9) Confidence 0.08 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8285224 Disease Relevance 0.16 Pain Relevance 0.83
E5555 showed >90% inhibition of the platelet thrombin receptor at 100 and 200 mg.
Negative_regulation (inhibition) of platelet thrombin receptor in platelet
10) Confidence 0.03 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2966970 Disease Relevance 0.70 Pain Relevance 0.03

General Comments

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