INT5847

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Context Info
Confidence 0.69
First Reported 1992
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 31
Total Number 33
Disease Relevance 11.11
Pain Relevance 6.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FOS) aging (FOS) nucleolus (FOS)
nucleus (FOS)
Anatomy Link Frequency
neuronal 2
embryos 1
FOS (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 24 100.00 Very High Very High Very High
Dynorphin 14 100.00 Very High Very High Very High
Morphine 11 98.70 Very High Very High Very High
chemokine 12 98.38 Very High Very High Very High
Enkephalin 20 98.00 Very High Very High Very High
tetrodotoxin 9 97.92 Very High Very High Very High
Hippocampus 25 97.00 Very High Very High Very High
Arthritis 108 96.72 Very High Very High Very High
Inflammation 189 96.48 Very High Very High Very High
ischemia 10 96.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 171 100.00 Very High Very High Very High
Necrosis 17 100.00 Very High Very High Very High
Aids-related Complex 14 100.00 Very High Very High Very High
Osteogenic Sarcomas 10 100.00 Very High Very High Very High
Sarcoma 2 100.00 Very High Very High Very High
Thymoma 2 99.88 Very High Very High Very High
Carcinoma 5 98.66 Very High Very High Very High
Convulsion 6 98.44 Very High Very High Very High
Disease 103 97.92 Very High Very High Very High
Metastasis 90 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Characterization of the time course of mRNA expression for Camk1g, Gpd1, c-fos and Egr1 demonstrates that altered expression of these transcripts also occurs at times earlier than 6 h following acute, oral pyrethroid exposure (Figure 4, Additional file 5).
Transcription (expression) of c-fos
1) Confidence 0.69 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.14 Pain Relevance 0.13
Dose-dependent changes in the transcription of several genes (Camk1g, Ddc, Gpd3, c-fos and Egr1) were discovered and successfully confirmed.
Transcription (transcription) of c-fos
2) Confidence 0.69 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.19 Pain Relevance 0.03
DREAM (calsenilin/KChIP3) is an EF-hand calcium-binding protein that binds to specific DNA sequences and regulates Ca2+-induced transcription of prodynorphin and c-fos genes.
Transcription (transcription) of c-fos
3) Confidence 0.69 Published 2008 Journal Biochemistry Section Abstract Doc Link 18201103 Disease Relevance 0 Pain Relevance 0
DADLE acted against this effect of METH at least in part by attenuating the mRNA expressions of a tumor necrosis factor p53 and an immediate early gene c-fos.
Transcription (expressions) of c-fos associated with necrosis and cancer
4) Confidence 0.69 Published 2000 Journal J. Biomed. Sci. Section Abstract Doc Link 10810237 Disease Relevance 0.47 Pain Relevance 0.55
In addition to the prodynorphin promoter, DREAM represses transcription from the early response gene c-fos.
Transcription (transcription) of c-fos
5) Confidence 0.69 Published 1999 Journal Nature Section Abstract Doc Link 10078534 Disease Relevance 0.08 Pain Relevance 0.12
Morphine at concentrations of 10(-12) M to 10(-10) M also modulated mRNA expression of early growth related genes (c-fos, c-jun and c-myc).
Transcription (expression) of c-fos associated with morphine
6) Confidence 0.69 Published 1998 Journal Kidney Int. Section Abstract Doc Link 9461094 Disease Relevance 0.48 Pain Relevance 0.76
In this study, gene transcription for three immediate early genes, c-fos, c-jun and NGFI-A, and three neuropeptide genes, enkephalin, dynorphin and neuropeptide Y, was investigated using nuclear run-on assays following a single injection of the convulsant pentylenetetrazole (PTZ).
Spec (investigated) Transcription (transcription) of c-fos associated with dynorphin, neuropeptide and enkephalin
7) Confidence 0.69 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8170346 Disease Relevance 0.17 Pain Relevance 0.44
At 15 min following PTZ injection, only transcription for c-fos was increased.
Transcription (transcription) of c-fos
8) Confidence 0.69 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8170346 Disease Relevance 0.16 Pain Relevance 0.51
Thus, regulation of immediate early and neuropeptide gene mRNA levels and immunoreactivity occurs, at least in part, at the level of transcription for the genes encoding neuropeptide Y, dynorphin, c-fos, c-jun, and NGFI-A.
Transcription (transcription) of c-fos associated with dynorphin and neuropeptide
9) Confidence 0.69 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8170346 Disease Relevance 0.14 Pain Relevance 0.49
The immediate early gene (IEG) transcription factor c-fos coordinates changes in the pattern of long term gene expression and, therefore, it may be involved in mediating epigenetic control during neurodevelopment.
Transcription (transcription) of c-fos
10) Confidence 0.67 Published 1995 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 8612322 Disease Relevance 0 Pain Relevance 0.18
Like other transcription factors, such as AP-1 proteins, c-fos, and c-Jun, phosphorylated CREB may participate in the downstream signal transduction cascade in the longer lasting changes in synaptic plasticity.
Transcription (transcription) of c-fos
11) Confidence 0.67 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0.43 Pain Relevance 0.71
Fifteen days after the lesion of the AC, the number of c-Fos Ir nuclei was 36% lower that in controls and 90?
Transcription (number) of c-Fos
12) Confidence 0.67 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2981384 Disease Relevance 0 Pain Relevance 0
The immediate early transcription factors c-fos and Egr1 were upregulated by deltamethrin and permethrin.
Transcription (transcription) of c-fos
13) Confidence 0.67 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.09 Pain Relevance 0.12
c-Fos densitometry and morphometry
Transcription (densitometry) of c-Fos
14) Confidence 0.67 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2981384 Disease Relevance 0 Pain Relevance 0
days after cortical ablation, the number of c-Fos immunoreactive neuronal nuclei in the IC tends to increase relative to shorter post-lesion times (1 and 15?
Transcription (nuclei) of c-Fos in neuronal
15) Confidence 0.67 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2981384 Disease Relevance 0 Pain Relevance 0.08
days after the lesion, the distribution of c-Fos Ir neuronal nuclei in the IC was similar to the 90?
Transcription (distribution) of c-Fos in neuronal
16) Confidence 0.67 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2981384 Disease Relevance 0 Pain Relevance 0
The 27 upregulated genes encoded seven transcription factors (JUN, EGR1, JUNB, FOS, FOSB, MYCN, and SNAIL1), four of which are components of the AP-1 transcription factor family (JUN, JUNB, FOS, and FOSB).
Transcription (transcription) of AP-1
17) Confidence 0.53 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.18 Pain Relevance 0.09
The 27 upregulated genes encoded seven transcription factors (JUN, EGR1, JUNB, FOS, FOSB, MYCN, and SNAIL1), four of which are components of the AP-1 transcription factor family (JUN, JUNB, FOS, and FOSB).
Transcription (transcription) of FOS
18) Confidence 0.53 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.19 Pain Relevance 0.09
The 27 upregulated genes encoded seven transcription factors (JUN, EGR1, JUNB, FOS, FOSB, MYCN, and SNAIL1), four of which are components of the AP-1 transcription factor family (JUN, JUNB, FOS, and FOSB).
Transcription (transcription) of FOS
19) Confidence 0.53 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.12 Pain Relevance 0.09
In contrast, for permethrin no change in the expression of c-fos and Egr1 mRNA was observed across dose groups in the qRT-PCR cohort.
Transcription (expression) of c-fos
20) Confidence 0.52 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.15 Pain Relevance 0.09

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