INT58602

Context Info Confidence 0.65 First Reported 1993 Last Reported 2010 Negated 2 Speculated 2 Reported most in Body Documents 34 Total Number 37 Disease Relevance 25.26 Pain Relevance 3.74

Anatomy Link Frequency respiratory 4 fibroblasts 3 alveolar macrophages 2 Chest 1 mere 1 HMI (Homo sapiens)

Pain Link Frequency Relevance Heat tetrodotoxin 123 100.00 Inflammation 54 100.00 analgesia 28 100.00 Angina 14 99.48 Osteoarthritis 17 99.44 Codeine 1 97.04 corticosteroid 153 96.16 Analgesic 2 95.00 imagery 24 92.48 Pain 18 86.84

Disease Link Frequency Relevance Heat Invasive Pulmonary Aspergillosis 1033 100.00 Infection 72 100.00 INFLAMMATION 56 100.00 Sepsis 9 100.00 Hemoptysis 9 99.78 Angina 14 99.48 Osteoarthritis 17 99.44 Disease 50 99.32 Respiratory Failure 9 99.18 Nicotine Addiction 3 98.74

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We examined the effect of the IPA-RCP by measuring rSO2 which represents the brain blood perfusion.

Spec (examined) Gene_expression (effect) of IPA in blood

1) Confidence 0.65 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2987928 Disease Relevance 0 Pain Relevance 0

Thus, the clinical effectiveness of the IPA-RCP through a cannulae inserted to the SVC is unknown field.

Gene_expression (effectiveness) of IPA

2) Confidence 0.65 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2987928 Disease Relevance 0 Pain Relevance 0

The data were analysed using IPA.

Gene_expression (using) of IPA

3) Confidence 0.57 Published 2010 Journal Psychol Psychother Section Body Doc Link 19712543 Disease Relevance 0 Pain Relevance 0

IPA was not effective in one patient who required 6 doses of intravenous meperidine.

Neg (not) Gene_expression (effective) of IPA associated with analgesia

4) Confidence 0.51 Published 1993 Journal J. Pediatr. Surg. Section Abstract Doc Link 8301460 Disease Relevance 0.18 Pain Relevance 1.22

One of limitations of the present study was that ion channels, BKCa, Ito, IKir and ICl.vol, and INa.TTX, and INa.TTXR, were heterogeneously expressed within the same species of cultured human cardiac fibroblasts.

Gene_expression (expressed) of Ito in fibroblasts associated with tetrodotoxin

5) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2751830 Disease Relevance 0.13 Pain Relevance 0.10

One of limitations of the present study was that ion channels, BKCa, Ito, IKir and ICl.vol, and INa.TTX, and INa.TTXR, were heterogeneously expressed within the same species of cultured human cardiac fibroblasts.

Gene_expression (expressed) of Ito in fibroblasts associated with tetrodotoxin

6) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2751830 Disease Relevance 0.13 Pain Relevance 0.10

Changes in learning performances over hours may involve plastic changes in the brains of IPA-exposed bees, such as modifications of synaptic transmission and/or neural excitability in the olfactory pathway.

Gene_expression (bees) of IPA-exposed in neural

7) Confidence 0.39 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2936933 Disease Relevance 0 Pain Relevance 0.04

Learning impairment is specifically caused by exposure to IPA

Gene_expression (exposure) of IPA

8) Confidence 0.39 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2936933 Disease Relevance 0.07 Pain Relevance 0

Similarly, the effect of methyl salicylate geraniol exposure was compared with that obtained in its corresponding two control groups (oil-exposed and IPA-exposed) (Figure 5B).

Gene_expression (exposed) of IPA-exposed

9) Confidence 0.39 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2936933 Disease Relevance 0 Pain Relevance 0

However, in order to study the effects of IPA exposure on associative learning irrespective of a decrease in appetitive motivation, we discarded IPA-exposed bees that did not respond to the US.

Gene_expression (exposure) of IPA

10) Confidence 0.39 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2936933 Disease Relevance 0.06 Pain Relevance 0

Importantly, this effect cannot be interpreted as a mere consequence of impaired perception of the conditioned odorant (the CS), as bees exposed to IPA still discriminate the CS from a novel odorant in a generalization test (they do so even better than controls).

Gene_expression (exposed) of IPA in mere

11) Confidence 0.39 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2936933 Disease Relevance 0.39 Pain Relevance 0

The effect of geraniol exposure was analyzed relative to that obtained in the two other groups (oil-exposed and IPA-exposed), which were studied in parallel (Figure 5A).

Gene_expression (exposed) of IPA-exposed

12) Confidence 0.39 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2936933 Disease Relevance 0 Pain Relevance 0

h) between IPA exposure and olfactory conditioning.

Gene_expression (exposure) of IPA in olfactory

13) Confidence 0.39 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2936933 Disease Relevance 0.09 Pain Relevance 0

Exposure to IPA affected learning in a dose-dependent manner (Dose: F?

Gene_expression (Exposure) of IPA

14) Confidence 0.39 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2936933 Disease Relevance 0 Pain Relevance 0

We thus exposed independent groups of bees to oil, IPA, methyl salicylate or geraniol (all at the same concentration: 24%) for 30?

Gene_expression (exposed) of IPA

15) Confidence 0.39 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2936933 Disease Relevance 0.06 Pain Relevance 0

However, Ito (likely encoded by Kv4.2/Kv4.3) and IKDR (likely encoded by Kv1.5/Kv1.6) were present only in a small population of human cardiac fibroblasts (15% and 14%, respectively) (Figs. 1–3).

Gene_expression (present) of Ito in fibroblasts

16) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2751830 Disease Relevance 0 Pain Relevance 0.12

Despite women's doctors being informed that they screened positive, half reported that IPA was not raised in subsequent consultations.

Neg (not) Gene_expression (raised) of IPA

17) Confidence 0.23 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2823699 Disease Relevance 0 Pain Relevance 0

There is also a reduction in total HDAC activity in peripheral lung, bronchial biopsy specimens, and alveolar macrophages from COPD patients, and this is correlated with disease severity and with increased gene expression of IL-8 (Ito et al., 2005).

Gene_expression (expression) of Ito in alveolar macrophages associated with pulmonary disease and disease

18) Confidence 0.18 Published 2008 Journal Interdisciplinary Toxicology Section Body Doc Link PMC2993477 Disease Relevance 1.13 Pain Relevance 0.26

HDAC activity is reduced in alveolar macrophages of cigarette smokers compared to nonsmokers, and this is correlated with increased expression of inflammatory genes in these cells (Ito et al., 2001).

Gene_expression (expression) of Ito in alveolar macrophages associated with nicotine addiction and inflammation

19) Confidence 0.14 Published 2008 Journal Interdisciplinary Toxicology Section Body Doc Link PMC2993477 Disease Relevance 1.24 Pain Relevance 0.27

BAL culture was somewhat more sensitive than qPCR in detecting IPA (sensitivity 84.6 %) and had high specificity (100%).

Gene_expression (detecting) of IPA associated with invasive pulmonary aspergillosis

20) Confidence 0.13 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2440748 Disease Relevance 0.46 Pain Relevance 0

General Comments

This test has worked.