INT5863

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Context Info
Confidence 0.40
First Reported 1992
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 1.44
Pain Relevance 2.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr2) intracellular (Egr2) DNA binding (Egr2)
ligase activity (Egr2) cytoplasm (Egr2)
Anatomy Link Frequency
medulla 1
medial 1
brain 1
adrenal cortex 1
T cell 1
Egr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Thalamus 18 99.40 Very High Very High Very High
medulla 8 98.92 Very High Very High Very High
dopamine receptor 2 98.08 Very High Very High Very High
opiate 2 96.72 Very High Very High Very High
withdrawal 4 96.44 Very High Very High Very High
chemokine 16 96.12 Very High Very High Very High
qutenza 6 92.60 High High
antagonist 36 90.92 High High
cytokine 26 84.80 Quite High
Inflammation 34 84.40 Quite High
Disease Link Frequency Relevance Heat
Repression 2 99.56 Very High Very High Very High
Shock 2 99.12 Very High Very High Very High
Stress 14 93.20 High High
INFLAMMATION 38 84.40 Quite High
Immunization 8 55.04 Quite High
Autoimmune Disease 18 50.00 Quite Low
Death 4 44.64 Quite Low
Multiple Sclerosis 80 5.00 Very Low Very Low Very Low
Disease 24 5.00 Very Low Very Low Very Low
Experimental Autoimmune Neuritis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All of these IEGs except egr-2 were rapidly induced in the adrenal cortex and medulla.
Positive_regulation (induced) of egr-2 in medulla associated with medulla
1) Confidence 0.40 Published 2000 Journal Brain Res. Section Abstract Doc Link 10986333 Disease Relevance 0.41 Pain Relevance 0.34
We now report that, like zif268, krox-20 is rapidly and transiently activated by electroconvulsive shock treatment (ECT), D1 dopamine receptor activation, and opiate withdrawal.
Positive_regulation (activated) of krox-20 associated with dopamine receptor, shock, opiate and withdrawal
2) Confidence 0.40 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1317498 Disease Relevance 0.10 Pain Relevance 0.19
The early growth response genes 2 and 3 (egr2 and egr3) were strongly up-regulated (Supplementary Fig. 4D).
Positive_regulation (up-regulated) of egr2
3) Confidence 0.37 Published 2010 Journal Brain Section Body Doc Link PMC2892943 Disease Relevance 0.20 Pain Relevance 0.35
With repeated stimulation, i.e. when the noxious stimulus was applied to the contralateral hindpaw 6 h after the sciatic stimulation, there was again no induction of c-Fos, FosB or Krox-20 in the medial thalamus; but there was an increase in c-Jun and Krox-24, and a decrease in JunD levels.
Neg (no) Positive_regulation (induction) of Krox-20 in medial associated with thalamus
4) Confidence 0.32 Published 2001 Journal Neuroscience Section Abstract Doc Link 11744254 Disease Relevance 0.06 Pain Relevance 0.61
The observed strong elevations of the transcription factors egr-2 and -3, which have been recently identified as potent regulators of T cell anergy (Safford et al., 2005), point in this direction.
Positive_regulation (elevations) of egr-2 in T cell
5) Confidence 0.32 Published 2010 Journal Brain Section Body Doc Link PMC2892943 Disease Relevance 0.07 Pain Relevance 0.20
Activation of the zinc finger encoding gene krox-20 in adult rat brain: comparison with zif268.
Positive_regulation (Activation) of krox-20 in brain
6) Confidence 0.27 Published 1992 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 1317498 Disease Relevance 0.09 Pain Relevance 0.17
With coincident stimulation, i.e. when a stimulus was applied to each hindpaw simultaneously, c-Fos and Krox-24 remained absent; but there was a marked induction of FosB and Krox-20, a strong repression of c-Jun, and no effect or a reduction of the basal levels of JunD.
Positive_regulation (induction) of Krox-20 associated with repression
7) Confidence 0.22 Published 2001 Journal Neuroscience Section Abstract Doc Link 11744254 Disease Relevance 0.10 Pain Relevance 0.45
All of these IEGs except egr-2 were rapidly induced in the adrenal cortex and medulla.
Positive_regulation (induced) of egr-2 in adrenal cortex associated with medulla
8) Confidence 0.14 Published 2000 Journal Brain Res. Section Abstract Doc Link 10986333 Disease Relevance 0.41 Pain Relevance 0.34

General Comments

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