INT58691

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Context Info
Confidence 0.50
First Reported 1993
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 26
Total Number 26
Disease Relevance 15.19
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CD8A) plasma membrane (CD8A)
Anatomy Link Frequency
T-cell 23
lymphocytes 4
mast cells 3
immune system 2
effector T cells 2
CD8A (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 36 99.68 Very High Very High Very High
Pain 28 96.88 Very High Very High Very High
cytokine 173 96.20 Very High Very High Very High
Acupuncture 56 95.64 Very High Very High Very High
Arthritis 66 89.04 High High
Bioavailability 2 88.52 High High
Inflammation 80 82.32 Quite High
Inflammatory response 6 67.56 Quite High
rheumatoid arthritis 36 66.36 Quite High
cva 4 63.04 Quite High
Disease Link Frequency Relevance Heat
Diffuse Cutaneous Leishmaniasis 370 100.00 Very High Very High Very High
Leishmaniasis 250 100.00 Very High Very High Very High
Malaria 25 100.00 Very High Very High Very High
Viral Infection 18 99.96 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 171 99.72 Very High Very High Very High
Chlamydia Infection 88 99.16 Very High Very High Very High
Cancer 162 99.12 Very High Very High Very High
Hepatitis C Virus Infection 74 98.96 Very High Very High Very High
Infection 223 98.68 Very High Very High Very High
Cirrhosis 28 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It leads to MHC-restricted clonal expansion of CD8 T cells characterized by circulating CD8 hyperlymphocytosis and CD8 T-cell infiltration in organs.
Positive_regulation (circulating) of Gene_expression (hyperlymphocytosis) of CD8 in T-cell
1) Confidence 0.50 Published 2010 Journal Muscle Nerve Section Abstract Doc Link 19882634 Disease Relevance 1.10 Pain Relevance 0.09
It leads to MHC-restricted clonal expansion of CD8 T cells characterized by circulating CD8 hyperlymphocytosis and CD8 T-cell infiltration in organs.
Positive_regulation (circulating) of Gene_expression (infiltration) of CD8 in T-cell
2) Confidence 0.50 Published 2010 Journal Muscle Nerve Section Abstract Doc Link 19882634 Disease Relevance 1.10 Pain Relevance 0.10
Our results show significant differences between CD8 of both groups: while CD8 from LCL patients produce high levels of IFN?
Positive_regulation (levels) of Gene_expression (produce) of CD8 associated with leishmaniasis
3) Confidence 0.47 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 1.26 Pain Relevance 0.09
In conclusion, our results demonstrate that intradermally injected HIV lipopeptides induce complementary CD4+ and CD8+ T-cell responses.
Positive_regulation (induce) of Gene_expression (responses) of CD8 in T-cell associated with acquired immune deficiency syndrome or hiv infection
4) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1942115 Disease Relevance 0.61 Pain Relevance 0
Due to their structure, lipopeptides are known to induce a CD8+ T-cell response, although they also elicit a CD4+ T-cell response [9], [13].
Positive_regulation (induce) of Gene_expression (response) of CD8 in T-cell
5) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1942115 Disease Relevance 0.52 Pain Relevance 0.06
Prior to the cytotoxic experiments, the optimal CD8: MOi ratio had been established as 10?
Positive_regulation (established) of Gene_expression (ratio) of CD8
6) Confidence 0.34 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 1.00 Pain Relevance 0
We found that PD-1 expression in CD8+ of DCL patients was significantly reduced after stimulation with both TLR2 agonists, LPG (p?
Positive_regulation (after) of Gene_expression (expression) of CD8 associated with agonist and diffuse cutaneous leishmaniasis
7) Confidence 0.34 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 0.58 Pain Relevance 0.14
Prior to the cytotoxic experiments, the optimal CD8: MOi ratio had been established as 10?
Positive_regulation (optimal) of Gene_expression (ratio) of CD8
8) Confidence 0.34 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 0.99 Pain Relevance 0
In this viral infection, CD8 clones are initially generated, but cytotoxicity and proliferation are lost at an early stage, while IFN?
Positive_regulation (generated) of Gene_expression (clones) of CD8 associated with viral infection
9) Confidence 0.34 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 0.93 Pain Relevance 0
First, the increase of CD2+, CD4+, CD8+, CD11b+, CD16+, CD19+ and CD56+ cell counts as well as the levels of IL-1?
Positive_regulation (increase) of Gene_expression (cell) of CD8
10) Confidence 0.33 Published 2007 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2176150 Disease Relevance 0 Pain Relevance 0.40
Compared with controls, IBS patients had increased numbers of CD3+, CD4+, and CD8+ T cells and mast cells (P<0.001).
Positive_regulation (increased) of Gene_expression (numbers) of CD8 in mast cells
11) Confidence 0.29 Published 2009 Journal Am. J. Gastroenterol. Section Body Doc Link 19174797 Disease Relevance 0 Pain Relevance 0
Although MVA85A was known to induce CD4+ T cell mediated immunity, we now show that it also induces detectable CD8+ T cell responses, in the few subjects we were able to study in detail in this trial.
Positive_regulation (induces) of Gene_expression (detectable) of CD8 in T cell
12) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2488375 Disease Relevance 0.27 Pain Relevance 0
CONCLUSION: Our results suggest that elevated levels of serum sIL-2R in early RA likely reflect generalized immune system activation, not always associated with elevated serum sCD4 or sCD8 levels or varying with other measures of disease activity in RA.


Neg (not) Positive_regulation (elevated) of Gene_expression (levels) of sCD8 in immune system
13) Confidence 0.25 Published 1993 Journal J. Rheumatol. Section Body Doc Link 8308770 Disease Relevance 0.11 Pain Relevance 0
Representative FC data from a patient and control are shown in Figure 3B, with Figure 3C indicating the relative increase in CD8+ T cell associated TRAIL and its receptor expression.
Positive_regulation (increase) of Gene_expression (expression) of CD8 in T cell
14) Confidence 0.25 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936350 Disease Relevance 0.63 Pain Relevance 0.21
Up to now, published studies have used autologous tumour cells as antigenic stimulations, which can lead to polyclonal expansion of specific CD8 and CD4 cells.
Positive_regulation (lead) of Gene_expression (expansion) of CD8 associated with cancer
15) Confidence 0.21 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2952949 Disease Relevance 1.02 Pain Relevance 0
In humans, before treatment with androgens, patients who have Klinefelter's syndrome but not RAD have very diminished levels of testosterone associated with high levels of IgG, IgA, IgM, IL-2, and IL-4 and with an absolute increase of CD3+, CD4+, and the CD4+/CD8+ ratio [30].
Positive_regulation (increase) of Gene_expression (ratio) of CD8 associated with autoimmune disease and syndrome
16) Confidence 0.17 Published 2001 Journal Arthritis Res Section Body Doc Link PMC64847 Disease Relevance 0.83 Pain Relevance 0.06
Generation of antigen-specific CD8+ T cell lines after MACS sorting of HLA-B27 tetramer-positive T cells
Positive_regulation (Generation) of Gene_expression (lines) of CD8 in T cells
17) Confidence 0.16 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064864 Disease Relevance 0.43 Pain Relevance 0.03
While we did not observe major differences in the level of CD4 cells between vaccinated and non vaccinated macaques (data not shown), we did observe an augmentation of the number of CD8 lymphocytes in Tat Oyi vaccinated macaques (Fig. 3).
Positive_regulation (augmentation) of Gene_expression (lymphocytes) of CD8 in lymphocytes
18) Confidence 0.16 Published 2006 Journal Retrovirology Section Body Doc Link PMC1434768 Disease Relevance 0.72 Pain Relevance 0
These results are supported by the increased expression of activation markers (CD69 and HLA-DR) on CD4+ and CD8+ T cells at symptom onset.
Positive_regulation (increased) of Gene_expression (expression) of CD8 in T cells
19) Confidence 0.15 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC3013083 Disease Relevance 0.59 Pain Relevance 0.28
Overall, vaccination induced an increase in the frequency of malaria specific CD4+ and CD8+ lymphocytes in 16 out of 22 volunteers (73%) (Table 4).
Positive_regulation (increase) of Gene_expression (lymphocytes) of CD8 in lymphocytes associated with malaria
20) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2749339 Disease Relevance 0.23 Pain Relevance 0

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