INT58861

Context Info Confidence 0.25 First Reported 1993 Last Reported 2005 Negated 1 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.10 Pain Relevance 1.26

cytosol (Ldha) mitochondrion (Ldha) oxidoreductase activity (Ldha) carbohydrate metabolic process (Ldha) cytoplasm (Ldha)

Ldha (Mus musculus)

Pain Link Frequency Relevance Heat ketamine 15 99.98 Enkephalin 9 99.82 anesthesia 1 77.56 cytokine 1 25.00 Inflammation 1 25.00

Disease Link Frequency Relevance Heat Death 1 99.60 INFLAMMATION 1 25.00 Toxicity 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

When the administered concentration reached 1000 microM, ketamine caused a release of lactate dehydrogenase and cell death.

Positive_regulation (caused) of Localization (release) of lactate dehydrogenase associated with ketamine and death

1) Confidence 0.25 Published 2005 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 15781291 Disease Relevance 0.10 Pain Relevance 0.56

MENK did not elicit any significant extracellular release of lactate dehydrogenase (LDH) either, indicating that, under the experimental conditions described, the cells remained intact.

Neg (not) Positive_regulation (elicit) of Localization (release) of lactate dehydrogenase associated with enkephalin

2) Confidence 0.23 Published 1993 Journal Biomed. Pharmacother. Section Abstract Doc Link 8329664 Disease Relevance 0 Pain Relevance 0.70

General Comments

This test has worked.