INT5895

Context Info Confidence 0.78 First Reported 1982 Last Reported 2010 Negated 11 Speculated 8 Reported most in Abstract Documents 525 Total Number 533 Disease Relevance 120.67 Pain Relevance 407.29

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)

Anatomy Link Frequency neurons 31 brain 17 spinal cord 13 DRG 11 ovary 10 Oprm1 (Mus musculus) Oprm1 - T180A (2) Oprm1 - T394A (1)

Pain Link Frequency Relevance Heat opioid receptor 8876 100.00 mu opioid receptor 6004 100.00 Morphine 4444 100.00 Opioid 3601 100.00 Pain 1072 100.00 tolerance 1039 100.00 agonist 1021 100.00 narcan 871 100.00 antinociception 787 100.00 Enkephalin 461 100.00

Disease Link Frequency Relevance Heat Targeted Disruption 1269 100.00 Drug Dependence 128 100.00 Urological Neuroanatomy 453 99.98 Endometriosis (extended) 35 99.96 Repression 515 99.92 Stress 417 99.92 Opiate Addiction 274 99.92 Neuropathic Pain 168 99.92 Nervous System Injury 24 99.92 Neuroblastoma 133 99.84

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Anatomy

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The mu-opioid receptor (OPRM1) is expressed in brain regions implicated in reward and locomotor processes.

Gene_expression (expressed) of mu-opioid receptor in brain associated with opioid receptor

1) Confidence 0.78 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 14969743 Disease Relevance 0.20 Pain Relevance 0.43

The mu-opioid receptor (OPRM1) is expressed in brain regions implicated in reward and locomotor processes.

Gene_expression (expressed) of OPRM1 in brain associated with opioid receptor

2) Confidence 0.78 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 14969743 Disease Relevance 0.20 Pain Relevance 0.43

To examine whether the low degree of endocytosis induced by morphine contributes to tolerance and dependence, we generated a knockin mouse that expresses a mutant MOP-R that undergoes morphine-induced endocytosis.

Gene_expression (expresses) of MOP-R associated with targeted disruption, addiction, tolerance and morphine

3) Confidence 0.78 Published 2008 Journal Curr. Biol. Section Abstract Doc Link 18207746 Disease Relevance 0.32 Pain Relevance 1.67

Detection of genetic variation affecting OPRM1 expression or mu opioid receptor function would be an important step towards understanding the origins of inter-individual variation in response to mu opioid receptor ligands and in diseases of substance dependence.

Gene_expression (expression) of OPRM1 associated with drug dependence, addiction, mu opioid receptor and disease

4) Confidence 0.78 Published 1997 Journal Mol. Psychiatry Section Abstract Doc Link 9399694 Disease Relevance 0.36 Pain Relevance 1.09

Detection of genetic variation affecting OPRM1 expression or mu opioid receptor function would be an important step towards understanding the origins of inter-individual variation in response to mu opioid receptor ligands and in diseases of substance dependence.

Gene_expression (expression) of mu opioid receptor associated with drug dependence, addiction, mu opioid receptor and disease

5) Confidence 0.78 Published 1997 Journal Mol. Psychiatry Section Abstract Doc Link 9399694 Disease Relevance 0.36 Pain Relevance 1.09

These results suggest that the expression of mu-opioid receptor may contribute to locomotor sensitization induced by morphine, but that mu-opioid receptor does not play an important role in mediating sensitization to cocaine.

Gene_expression (expression) of mu-opioid receptor associated with opioid receptor, cocaine and morphine

6) Confidence 0.78 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12781916 Disease Relevance 0.51 Pain Relevance 1.24

Analysis of mouse brain mRNA by RT-PCR suggests that MOR-1Vii transcripts are expressed in all areas of the brain analyzed, whereas expression of MOR-1Vi transcripts was restricted to thalamus and striatum.

Gene_expression (expression) of MOR in striatum associated with thalamus and opioid receptor

7) Confidence 0.78 Published 2007 Journal Gene Section Abstract Doc Link 17156941 Disease Relevance 0.08 Pain Relevance 0.74

Analysis of mouse brain mRNA by RT-PCR suggests that MOR-1Vii transcripts are expressed in all areas of the brain analyzed, whereas expression of MOR-1Vi transcripts was restricted to thalamus and striatum.

Gene_expression (expressed) of MOR in striatum associated with thalamus and opioid receptor

8) Confidence 0.78 Published 2007 Journal Gene Section Abstract Doc Link 17156941 Disease Relevance 0.08 Pain Relevance 0.73

The time-dependent difference in the analgesic effect after chronic treatment or recovery from tolerance is closely related to that in the expression of mu-opioid receptor.

Gene_expression (expression) of mu-opioid receptor associated with analgesic, tolerance and opioid receptor

9) Confidence 0.78 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12626644 Disease Relevance 0 Pain Relevance 1.52

We investigated possible variations in the function and the profile of expression of the mu-opioid receptor system in three groups of adult mice from known IUP: 2M mice (located between two males), 0M (between two females), and 1M (between a male and a female).

Gene_expression (expression) of mu-opioid receptor associated with opioid receptor

10) Confidence 0.78 Published 2003 Journal Psychoneuroendocrinology Section Abstract Doc Link 12573304 Disease Relevance 0 Pain Relevance 0.23

Glucocorticoid is involved in food-entrainable rhythm of mu-opioid receptor expression in mouse brainstem and analgesic effect of morphine.

Gene_expression (expression) of mu-opioid receptor in brainstem associated with medulla, analgesic, opioid receptor and morphine

11) Confidence 0.78 Published 2006 Journal J. Pharmacol. Sci. Section Title Doc Link 16682786 Disease Relevance 0 Pain Relevance 0.82

Because the manipulation of feeding schedule was unable to produce the food-entrainable rhythm in the expression of mu-opioid receptor in the brainstem of adrenalectomized mice, endogenous rhythm of glucocorticoid secretion seems to be involved in the mechanism by which the time-restricted feeding modulates the analgesic effects of morphine.

Gene_expression (expression) of mu-opioid receptor in brainstem associated with medulla, analgesic, opioid receptor and morphine

12) Confidence 0.78 Published 2006 Journal J. Pharmacol. Sci. Section Abstract Doc Link 16682786 Disease Relevance 0 Pain Relevance 1.09

The present study suggests that 24-h rhythm of morphine analgesic effect is consistent with 24-h rhythm of mu-opioid receptor expression.

Gene_expression (expression) of mu-opioid receptor associated with analgesic, opioid receptor and morphine

13) Confidence 0.78 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12626644 Disease Relevance 0 Pain Relevance 1.40

The current study used a recombinant herpes simplex virus type 1 to increase expression of the mu-opioid receptor (muOR) in primary afferent neurons.

Gene_expression (expression) of muOR in afferent neurons associated with herpes simplex virus and opioid receptor

14) Confidence 0.78 Published 2008 Journal Anesthesiology Section Abstract Doc Link 18212576 Disease Relevance 0.19 Pain Relevance 0.58

The current study used a recombinant herpes simplex virus type 1 to increase expression of the mu-opioid receptor (muOR) in primary afferent neurons.

Gene_expression (expression) of mu-opioid receptor in afferent neurons associated with herpes simplex virus and opioid receptor

15) Confidence 0.78 Published 2008 Journal Anesthesiology Section Abstract Doc Link 18212576 Disease Relevance 0.19 Pain Relevance 0.58

Enhanced peripheral analgesia using virally mediated gene transfer of the mu-opioid receptor in mice.

Gene_expression (transfer) of mu-opioid receptor associated with opioid receptor and analgesia

16) Confidence 0.78 Published 2008 Journal Anesthesiology Section Title Doc Link 18212576 Disease Relevance 0.19 Pain Relevance 0.61

Differences in expression of the mu opioid receptor are expected to contribute to differences in inter-individual (humans) or strain-specific (mice) responses to painful stimuli, opiate drugs, and addictive behaviors.

Gene_expression (expression) of mu opioid receptor associated with pain, mu opioid receptor, opiate and sprains and strains

17) Confidence 0.78 Published 2001 Journal Mamm. Genome Section Abstract Doc Link 11668392 Disease Relevance 0.37 Pain Relevance 0.46

In contrast, the expression level of MOR-1 mRNA in the brain of CXBK mice was similar to that found in C57BL/6 mice.

Gene_expression (expression) of MOR-1 mRNA in brain associated with opioid receptor

18) Confidence 0.78 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14686893 Disease Relevance 0.17 Pain Relevance 0.68

Reduced expression of a novel mu-opioid receptor (MOR) subtype MOR-1B in CXBK mice: implications of MOR-1B in the expression of MOR-mediated responses.

Gene_expression (expression) of MOR associated with pain and opioid receptor

19) Confidence 0.78 Published 2003 Journal Eur. J. Neurosci. Section Title Doc Link 14686893 Disease Relevance 0.20 Pain Relevance 1.07

Reduced expression of a novel mu-opioid receptor (MOR) subtype MOR-1B in CXBK mice: implications of MOR-1B in the expression of MOR-mediated responses.

Gene_expression (expression) of mu-opioid receptor associated with pain and opioid receptor

20) Confidence 0.78 Published 2003 Journal Eur. J. Neurosci. Section Title Doc Link 14686893 Disease Relevance 0.20 Pain Relevance 1.07

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