INT5904

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Context Info
Confidence 0.81
First Reported 1985
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 62
Total Number 63
Disease Relevance 36.37
Pain Relevance 14.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MPO) extracellular space (MPO) oxidoreductase activity (MPO)
aging (MPO) nucleus (MPO) lysosome (MPO)
Anatomy Link Frequency
neutrophils 20
monocytes 4
Shield 2
sputum 1
gastric juices 1
MPO (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 22 99.92 Very High Very High Very High
substance P 73 99.82 Very High Very High Very High
Potency 3 99.48 Very High Very High Very High
Inflammation 849 98.92 Very High Very High Very High
lidocaine 12 98.82 Very High Very High Very High
Neuropeptide 18 98.80 Very High Very High Very High
acular 14 98.76 Very High Very High Very High
Angina 67 98.48 Very High Very High Very High
rapifen 4 98.42 Very High Very High Very High
chemokine 54 97.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 428 100.00 Very High Very High Very High
Metaplasia 3 99.88 Very High Very High Very High
Adhesions 607 99.64 Very High Very High Very High
Inflammatory Bowel Disease 240 99.52 Very High Very High Very High
Disease 423 99.48 Very High Very High Very High
INFLAMMATION 986 98.92 Very High Very High Very High
Angina 56 98.48 Very High Very High Very High
Bacterial Respiratory Disease 20 98.00 Very High Very High Very High
Acute Coronary Syndrome 147 97.84 Very High Very High Very High
Frailty 6 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The heme peroxidase enzyme myeloperoxidase (MPO) is released by activated neutrophils and monocytes, where it uses hydrogen peroxide (H(2)O(2)) to catalyze the production of the potent oxidants hypochlorous acid (HOCl), hypobromous acid (HOBr) and hypothiocyanous acid (HOSCN) from halide and pseudohalide (SCN(-)) ions.
Localization (released) of MPO in monocytes associated with urological neuroanatomy
1) Confidence 0.81 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 19968966 Disease Relevance 0.58 Pain Relevance 0.43
This was in contrast to results with aseanostatin P5 which selectively inhibited FMLP-induced MPO release.
Localization (release) of MPO associated with urological neuroanatomy
2) Confidence 0.81 Published 1991 Journal J. Antibiot. Section Abstract Doc Link 1712007 Disease Relevance 0.49 Pain Relevance 0.44
In order to search for microbial modulators of the activity of neuropeptide, we established a screen based on substance P (SP)-induced myeloperoxidase (MPO) release from human polymorphonuclear leukocytes (PMN).
Localization (release) of myeloperoxidase in PMN associated with neuropeptide, urological neuroanatomy and substance p
3) Confidence 0.81 Published 1991 Journal J. Antibiot. Section Abstract Doc Link 1712007 Disease Relevance 0.32 Pain Relevance 0.45
In order to search for microbial modulators of the activity of neuropeptide, we established a screen based on substance P (SP)-induced myeloperoxidase (MPO) release from human polymorphonuclear leukocytes (PMN).
Localization (release) of MPO in PMN associated with neuropeptide, urological neuroanatomy and substance p
4) Confidence 0.81 Published 1991 Journal J. Antibiot. Section Abstract Doc Link 1712007 Disease Relevance 0.32 Pain Relevance 0.45
Pyrrolomycin group antibiotics inhibit substance P-induced release of myeloperoxidase from human polymorphonuclear leukocytes.
Localization (release) of myeloperoxidase in polymorphonuclear leukocytes associated with substance p
5) Confidence 0.81 Published 1991 Journal J. Antibiot. Section Title Doc Link 1712007 Disease Relevance 0.39 Pain Relevance 0.50
Based on this, we searched for microbial inhibitors against SP-induced MPO release.
Localization (release) of MPO associated with urological neuroanatomy and substance p
6) Confidence 0.81 Published 1991 Journal J. Antibiot. Section Abstract Doc Link 1712007 Disease Relevance 0.44 Pain Relevance 0.52
In addition, these compounds inhibited the f-Met-Leu-Phe (FMLP)-induced MPO release from PMN.
Localization (release) of MPO in PMN associated with urological neuroanatomy
7) Confidence 0.81 Published 1991 Journal J. Antibiot. Section Abstract Doc Link 1712007 Disease Relevance 0.43 Pain Relevance 0.49
Pyrrolomycin derivatives with an N-methylated pyrrole ring showed, however, a selective inhibition of the SP-induced MPO release.
Localization (release) of MPO associated with urological neuroanatomy and substance p
8) Confidence 0.81 Published 1991 Journal J. Antibiot. Section Abstract Doc Link 1712007 Disease Relevance 0.51 Pain Relevance 0.47
An actinomycete metabolite designated HS3, which turned out to be identical with dioxapyrrolomycin or A1-R2081, and structurally related pyrrolomycins were found to inhibit SP-induced MPO release.
Localization (release) of MPO associated with urological neuroanatomy and substance p
9) Confidence 0.81 Published 1991 Journal J. Antibiot. Section Abstract Doc Link 1712007 Disease Relevance 0.44 Pain Relevance 0.50
SP induced MPO release in a dose-dependent manner at concentrations ranging from 1 approximately 10 x 10(-4) M.
Localization (release) of MPO associated with urological neuroanatomy and substance p
10) Confidence 0.81 Published 1991 Journal J. Antibiot. Section Abstract Doc Link 1712007 Disease Relevance 0.39 Pain Relevance 0.47
This is indicative of a significant release of MPO
Localization (release) of MPO associated with urological neuroanatomy
11) Confidence 0.80 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276594 Disease Relevance 1.82 Pain Relevance 0.38
The heme peroxidase enzyme myeloperoxidase (MPO) is released by activated neutrophils and monocytes, where it uses hydrogen peroxide (H(2)O(2)) to catalyze the production of the potent oxidants hypochlorous acid (HOCl), hypobromous acid (HOBr) and hypothiocyanous acid (HOSCN) from halide and pseudohalide (SCN(-)) ions.
Localization (released) of peroxidase enzyme myeloperoxidase in monocytes associated with urological neuroanatomy
12) Confidence 0.70 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 19968966 Disease Relevance 0.58 Pain Relevance 0.43
MPO, most abundantly released upon PMN activation, has been demonstrated to have a clear effect on the development of IR induced organ damage.
Localization (released) of MPO associated with urological neuroanatomy
13) Confidence 0.70 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737143 Disease Relevance 0.95 Pain Relevance 0.16
data by Biasucci et al. [9] who had shown return of MPO to baseline levels
Localization (return) of MPO associated with urological neuroanatomy
14) Confidence 0.66 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276594 Disease Relevance 1.35 Pain Relevance 0.08
negative for troponin T, the areas under the curve for MPO were significantly
Localization (curve) of MPO associated with urological neuroanatomy
15) Confidence 0.66 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276594 Disease Relevance 1.24 Pain Relevance 0.13
We found that lidocaine added to human neutrophils in vitro markedly impaired the release of superoxide anion (O2-) and the granule enzymes lysozyme and myeloperoxidase after stimulation by phorbol myristate acetate or opsonized zymosan.
Localization (release) of myeloperoxidase in neutrophils associated with lidocaine
16) Confidence 0.65 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2997433 Disease Relevance 0.26 Pain Relevance 0.83
In particular, we investigated in vitro the intracellular calcium concentration ([Ca2+](i)), the level of NO released by PMN and platelets, and the PMN myeloperoxidase activity after incubation with disodium pamidronate, since there was a postulated modulatory effect of this aminosubstituted bisphosphonate on leukocytes both in vitro and in vivo.
Neg (NO) Localization (released) of myeloperoxidase in platelets
17) Confidence 0.63 Published 2009 Journal Cell. Mol. Biol. Lett. Section Abstract Doc Link 19238333 Disease Relevance 0.27 Pain Relevance 0.18
We investigated the effect of fentanyl and alfentanil on superoxide anion production, hydrogen peroxide generation, and activity of released myeloperoxidase in vitro.
Localization (released) of myeloperoxidase associated with rapifen
18) Confidence 0.62 Published 1993 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 8391745 Disease Relevance 0.09 Pain Relevance 0.18
Neutrophil infiltration and release of myeloperoxidase
Localization (release) of myeloperoxidase in Neutrophil
19) Confidence 0.62 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737143 Disease Relevance 0.38 Pain Relevance 0.10
It was shown that water extract of HP can activate neutrophils and enhance the secretion of MPO.39 CAT is a ubiquitous, well-studied enzyme that catalyses the decomposition of hydrogen peroxide (H2O2) into water and oxygen to protect cells from the damaging effects of H2O2.24 HP has been shown to produce CAT, but the reported amount of this enzyme secreted would not be sufficient to scavenge extra cellular oxidants.40 Almost all the previous studies on the association of with HP in adult population were performed in gastric mucosa.12,21,23 Some previous studies have reported that no CAT activity was found in most gastric juices, probably because of their low pH levels, and in some antral tissue specimens.41,42 Akcan, et al.2 reported no unchanged of MPO and SOD activity in gastric mucosa of childhood period with HP (+) and (-) subjects, and Bulbuloglu, et al.42 also reported no unchanged of CAT activity in antral mucosal between HP (+) and (-) subjects.
Localization (secretion) of MPO in gastric juices associated with urological neuroanatomy
20) Confidence 0.60 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2768243 Disease Relevance 0.82 Pain Relevance 0.09

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