INT59083

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Context Info
Confidence 0.70
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 9.09
Pain Relevance 4.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (IL1A) cytosol (IL1A) extracellular space (IL1A)
extracellular region (IL1A)
Anatomy Link Frequency
lung 4
connective tissue 2
IL1A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 123 100.00 Very High Very High Very High
cINOD 14 99.98 Very High Very High Very High
dexamethasone 7 99.12 Very High Very High Very High
chemokine 23 99.08 Very High Very High Very High
antagonist 3 98.96 Very High Very High Very High
substance P 9 98.94 Very High Very High Very High
Arthritis 106 96.64 Very High Very High Very High
abdominal pain 1 93.84 High High
agonist 1 92.04 High High
Inflammatory response 37 91.84 High High
Disease Link Frequency Relevance Heat
Hypercalcemia 7 99.96 Very High Very High Very High
Rickets 2 99.92 Very High Very High Very High
Osteoporosis 3 99.24 Very High Very High Very High
Arthritis 13 98.16 Very High Very High Very High
Rheumatoid Arthritis 106 96.64 Very High Very High Very High
Celiac Disease 7 95.56 Very High Very High Very High
Weight Loss 5 94.92 High High
Pneumonia 112 94.88 High High
Critical Illness 74 94.60 High High
Diarrhoea 3 94.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is suggested that these NSAIDs induce IL1 synthesis by diminishing PG levels.
Positive_regulation (induce) of Gene_expression (synthesis) of IL1 associated with cinod
1) Confidence 0.70 Published 1993 Journal J Lipid Mediat Section Abstract Doc Link 8357988 Disease Relevance 0.59 Pain Relevance 0.64
It is suggested that the stimulatory action of group 1 NSAID is due to inhibition of locally produced IL1 and consequent expression of growth factor activity.
Positive_regulation (due) of Gene_expression (expression) of IL1 associated with cinod
2) Confidence 0.50 Published 1999 Journal Z Rheumatol Section Abstract Doc Link 10441838 Disease Relevance 0.62 Pain Relevance 0.82
SP (10(-5) M) also induced a significant but transient increase in the production of IL-1alpha, IL-1beta, IL-1 receptor antagonist and IL-8 which was detectable by ELISA techniques 6 h after stimulation.
Positive_regulation (increase) of Gene_expression (production) of IL-1alpha associated with antagonist and substance p
3) Confidence 0.49 Published 1996 Journal Arch. Dermatol. Res. Section Abstract Doc Link 8932586 Disease Relevance 0 Pain Relevance 0.61
precursor resulting in an increase in the levels of active IL1-?
Positive_regulation (increase) of Gene_expression (levels) of IL1
4) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928273 Disease Relevance 0.79 Pain Relevance 0.19
IL1A:rs17561 is a non-synonymous SNP and increases processing of the IL1-?
Positive_regulation (increases) of Gene_expression (processing) of IL1
5) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928273 Disease Relevance 0.74 Pain Relevance 0.18
IL1A:rs17561 is a non-synonymous SNP and increases processing of the IL1-?
Positive_regulation (increases) of Gene_expression (processing) of IL1A
6) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928273 Disease Relevance 0.75 Pain Relevance 0.19
Overproduction of cytokines IL-1 alpha, IL-1 beta and TNF-alpha increases bone resorption, which is further accelerated by hyperparathyroidism connected with malabsorption of calcium and vitamin D.
Positive_regulation (increases) of Gene_expression (Overproduction) of IL-1 alpha associated with hypercalcemia and cytokine
7) Confidence 0.37 Published 2009 Journal Cas. Lek. Cesk. Section Abstract Doc Link 19642305 Disease Relevance 1.70 Pain Relevance 0.17
DEX was also found to be a potent inhibitor of IL1-induced expression of the IL6 gene in connective tissue-type cells from the synovium of patients with RA.
Positive_regulation (induced) of Gene_expression (expression) of IL1 in connective tissue associated with dexamethasone and arthritis
8) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.85 Pain Relevance 0.79
Comparison of lung cytokines and chemokines at protein and gene levels showed comparable elevated levels of IL12B, CXCL8, IL1B, CCL3, IL1A and IL6 while IL17, TNF and IL10 were elevated only at the gene level.
Positive_regulation (elevated) of Gene_expression (levels) of IL1A in lung associated with chemokine and cytokine
9) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 0.56 Pain Relevance 0.14
Comparison of lung cytokines and chemokines at protein and gene levels showed comparable elevated levels of IL12B, CXCL8, IL1B, CCL3, IL1A and IL6 while IL17, TNF and IL10 were elevated only at the gene level.
Positive_regulation (elevated) of Gene_expression (levels) of IL1A in lung associated with chemokine and cytokine
10) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 0.56 Pain Relevance 0.14
However, during a 3 week period without oral hygiene, both groups developed increased levels of IL-1a, whereas IL-1?
Positive_regulation (increased) of Gene_expression (levels) of IL-1a
11) Confidence 0.04 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC2874215 Disease Relevance 0.96 Pain Relevance 0.30
However, during a 3 week period without oral hygiene, both groups developed increased levels of IL-1a, whereas IL-1?
Positive_regulation (whereas) of Gene_expression (levels) of IL-1a
12) Confidence 0.03 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC2874215 Disease Relevance 0.96 Pain Relevance 0.30

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