INT59194

From wiki-pain
Revision as of 01:14, 22 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 23
Disease Relevance 6.74
Pain Relevance 1.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (STS) nuclear envelope (STS) small molecule metabolic process (STS)
Golgi apparatus (STS) endoplasmic reticulum (STS) plasma membrane (STS)
Anatomy Link Frequency
liver 2
skin 2
EST 2
eukaryotic cell 1
endometrium 1
STS (Homo sapiens)
Pain Link Frequency Relevance Heat
monoamine 17 100.00 Very High Very High Very High
Angina 11 98.96 Very High Very High Very High
Pain 25 98.72 Very High Very High Very High
transdermal 60 77.60 Quite High
lidocaine 8 75.00 Quite High
local anesthetic 4 75.00 Quite High
depression 100 74.72 Quite High
antidepressant 75 66.76 Quite High
Analgesic 3 66.08 Quite High
Inflammation 49 65.20 Quite High
Disease Link Frequency Relevance Heat
Repression 24 99.48 Very High Very High Very High
Sprains And Strains 72 99.28 Very High Very High Very High
Cv General 3 Under Development 10 98.96 Very High Very High Very High
Apoptosis 818 98.76 Very High Very High Very High
Pain 21 98.72 Very High Very High Very High
Acute Coronary Syndrome 21 98.36 Very High Very High Very High
Shigella Infection 18 98.32 Very High Very High Very High
Calciphylaxis 82 96.08 Very High Very High Very High
Toxicity 9 95.92 Very High Very High Very High
Acne 2 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Posterior STS expresses activity common to slowly evolving mouth and hand movements, whereas responses in mid-STS are selective for mouth movements (Thompson et al. 2007) and responds more to biological point-light displays of body actions that are coherent than when they are scrambled (Grossman and Blake 2002).
Gene_expression (expresses) of STS in body
1) Confidence 0.59 Published 2010 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2820709 Disease Relevance 0.17 Pain Relevance 0.10
Results, listed in Table 1, reveal that at higher STS doses, the mean tyramine dose required to elicit a pressor response is significantly decreased.
Gene_expression (doses) of STS
2) Confidence 0.50 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656289 Disease Relevance 0 Pain Relevance 0
The STS appeared to be well-tolerated at the higher doses since approximately half of the patients received the higher doses of 9 and 12 mg/24 hours.
Gene_expression (appeared) of STS
3) Confidence 0.50 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656289 Disease Relevance 0.39 Pain Relevance 0
Reductions in the mean SBP and DBP were observed in the STS group compared with the placebo group (?
Gene_expression (group) of STS
4) Confidence 0.50 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656289 Disease Relevance 0.14 Pain Relevance 0.17
Five cloned human sulfotransferases (STs) were used in this study, namely, the phenol-sulfating form of ST (P-PST-1), the monoamine-sulfating form of ST (M-PST), estrogen-ST (EST), ST1B2, and dehydroepiandrosterone-ST (DHEA-ST), all of which are expressed in human liver.
Gene_expression (used) of STs in EST associated with monoamine
5) Confidence 0.42 Published 1999 Journal Drug Metab. Dispos. Section Abstract Doc Link 10460806 Disease Relevance 0 Pain Relevance 0.42
Five cloned human sulfotransferases (STs) were used in this study, namely, the phenol-sulfating form of ST (P-PST-1), the monoamine-sulfating form of ST (M-PST), estrogen-ST (EST), ST1B2, and dehydroepiandrosterone-ST (DHEA-ST), all of which are expressed in human liver.
Gene_expression (expressed) of STs in EST associated with monoamine
6) Confidence 0.42 Published 1999 Journal Drug Metab. Dispos. Section Abstract Doc Link 10460806 Disease Relevance 0 Pain Relevance 0.42
of the ES-D was .95 for both the PP and the OL samples.
Gene_expression (was) of ES-D
7) Confidence 0.38 Published 2010 Journal Depression Research and Treatment Section Body Doc Link PMC2989705 Disease Relevance 0.26 Pain Relevance 0.04
Nevertheless, steroid sulfatase (STS) is present in liver, skin, and many other tissues [20], and these tissues also contain 3?
Gene_expression (present) of steroid sulfatase in skin
8) Confidence 0.13 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2896848 Disease Relevance 0.05 Pain Relevance 0
Before surgery, the position of the STS, the IOS, and the PMTS were identified on MRI scans.
Gene_expression (position) of STS
9) Confidence 0.13 Published 2010 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2882824 Disease Relevance 0 Pain Relevance 0
Nevertheless, steroid sulfatase (STS) is present in liver, skin, and many other tissues [20], and these tissues also contain 3?
Gene_expression (present) of steroid sulfatase in skin
10) Confidence 0.12 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2896848 Disease Relevance 0.05 Pain Relevance 0
RESULTS: Aromatase and estrone sulfatase activities were detected in ectopic endometrium.
Gene_expression (detected) of estrone sulfatase in endometrium
11) Confidence 0.10 Published 1993 Journal Am. J. Obstet. Gynecol. Section Body Doc Link 8372890 Disease Relevance 0.08 Pain Relevance 0
The STS hypothesis
Gene_expression (hypothesis) of STS
12) Confidence 0.09 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1079905 Disease Relevance 0.91 Pain Relevance 0.26
The following is one of many possible antioxidant reactions as it scavenges ROS and may be responsible for producing glutathione:

STS is known to be a chelator of cations and has been used for over a century as an antidote for cyanide toxicity, topical treatments of acne and versicolor, and recently as a chemoprotectant against carboplatin and cisplatin toxicity.

Gene_expression (producing) of STS associated with toxicity and acne
13) Confidence 0.08 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1079905 Disease Relevance 1.12 Pain Relevance 0.10
The absence of changes in these key genes indicates that Shigella infection itself has a pro-survival effect on the eukaryotic cell that is not altered by the presence of STS.
Gene_expression (presence) of STS in eukaryotic cell associated with shigella infection
14) Confidence 0.05 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.31 Pain Relevance 0
The majority of these changes most likely represent the pro-survival state induced by Shigella, and these changes were enhanced upon STS exposure.
Gene_expression (exposure) of STS
15) Confidence 0.05 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.38 Pain Relevance 0
For the JUN probe, the same result was seen regardless of the presence of STS.
Gene_expression (presence) of STS
16) Confidence 0.05 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.06 Pain Relevance 0
Another example of increased expression due to the STS was seen in the induction of NFKBIA; there was approximately a 7-fold increase in WTSTS cells compared to a 3-fold increase in the U versus WT comparison.
Gene_expression (expression) of STS
17) Confidence 0.05 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.22 Pain Relevance 0
Additional possibilities for the inhibition of caspase-3 in the presence of STS include the repression of pro-apoptotic pathways (see below).
Gene_expression (presence) of STS associated with repression and apoptosis
18) Confidence 0.05 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.45 Pain Relevance 0.03
Nevertheless, there were some key distinctions that include higher levels of induction of some genes, opposite expression of genes in the presence of STS, enhancement of the pro-survival state related to NF-?
Gene_expression (expression) of STS
19) Confidence 0.05 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.35 Pain Relevance 0
Nevertheless, steroid sulfatase (STS) is present in liver, skin, and many other tissues [20], and these tissues also contain 3?
Gene_expression (present) of steroid sulfatase in liver
20) Confidence 0.05 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2896848 Disease Relevance 0.05 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox