INT59244

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Context Info
Confidence 0.57
First Reported 1993
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 3.02
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pla2g2a) extracellular space (Pla2g2a) endoplasmic reticulum (Pla2g2a)
Anatomy Link Frequency
platelet 1
DRG 1
gut 1
Pla2g2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
halothane 10 100.00 Very High Very High Very High
Inflammation 19 97.80 Very High Very High Very High
dexamethasone 2 97.58 Very High Very High Very High
anesthesia 2 96.52 Very High Very High Very High
Sciatica 5 95.92 Very High Very High Very High
aspirin 7 94.92 High High
Analgesic 1 93.88 High High
cINOD 7 85.56 High High
Sciatic nerve 3 77.28 Quite High
Hyperalgesia 4 65.84 Quite High
Disease Link Frequency Relevance Heat
Bacterial Respiratory Disease 2 99.32 Very High Very High Very High
Apoptosis 16 97.84 Very High Very High Very High
INFLAMMATION 19 97.80 Very High Very High Very High
Neuropathic Pain 2 97.28 Very High Very High Very High
Nerve Root Compression 2 95.92 Very High Very High Very High
Atherosclerosis 4 92.84 High High
Granuloma 1 91.80 High High
Stress 9 89.04 High High
Inflammatory Bowel Disease 5 83.96 Quite High
Injury 6 80.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To test this hypothesis, the authors assessed the ability of chymopapain to modulate the activity of the proinflammatory enzyme phospholipase A2 (PLA2) and to ameliorate behavioral changes associated with inflammatory neuropathy in an in vivo model of sciatica.
Regulation (modulate) of PLA2 associated with inflammation, neuropathic pain and sciatica
1) Confidence 0.57 Published 1997 Journal J. Neurosurg. Section Abstract Doc Link 9171179 Disease Relevance 0.81 Pain Relevance 0.39
Dexamethasone treatment significantly reduced all parameters determined, whereas p-bromophenacyl bromide had a significant inhibitory effect on PLA2 activity and PGE2 release, and indomethacin only restored PGE2 levels.
Regulation (effect) of PLA2 associated with dexamethasone
2) Confidence 0.41 Published 1993 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8375942 Disease Relevance 0.49 Pain Relevance 0.34
Therefore, we have investigated the effect of halothane on retinal PLA2 activity.
Spec (investigated) Regulation (effect) of PLA2 associated with halothane
3) Confidence 0.26 Published 1999 Journal J Ocul Pharmacol Ther Section Abstract Doc Link 10229494 Disease Relevance 0 Pain Relevance 0.41
For instance Paneth cells in the crypt base produce antimicrobials, such as defensins, lysozyme and Pla2g2a [15], to regulate and restrict the bacterial load in the gut lumen.
Regulation (regulate) of Pla2g2a in gut associated with bacterial respiratory disease
4) Confidence 0.21 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2311291 Disease Relevance 0.67 Pain Relevance 0.19
Changes in PGE2 and PLA2 in DRG neurons were detected with enzyme-linked immunosorbent assay (ELISA).
Regulation (Changes) of PLA2 in DRG
5) Confidence 0.03 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19191544 Disease Relevance 0.33 Pain Relevance 0
Its action on platelet TxA2 has highlighted its role as an anti-thrombotic agent in cardiovascular patients.
Regulation (action) of platelet TxA2 in platelet
6) Confidence 0.00 Published 2005 Journal J. Atheroscler. Thromb. Section Abstract Doc Link 16141621 Disease Relevance 0.72 Pain Relevance 0.49

General Comments

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