INT59245

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Context Info
Confidence 0.75
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 4.72
Pain Relevance 2.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pla2g1b) extracellular region (Pla2g1b)
Anatomy Link Frequency
neurons 2
spinal 1
macrophages 1
lymph 1
substantia gelatinosa 1
Pla2g1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hyperalgesia 26 100.00 Very High Very High Very High
Inflammation 51 99.70 Very High Very High Very High
Substantia gelatinosa neuron 9 99.70 Very High Very High Very High
intrathecal 2 99.40 Very High Very High Very High
substantia gelatinosa 6 99.24 Very High Very High Very High
Glutamate 4 99.04 Very High Very High Very High
Spinal cord 20 97.88 Very High Very High Very High
Antihyperalgesic 1 93.92 High High
COX2 1 93.60 High High
cva 6 88.88 High High
Disease Link Frequency Relevance Heat
Cancer 40 100.00 Very High Very High Very High
Hyperalgesia 30 100.00 Very High Very High Very High
Nociception 8 99.38 Very High Very High Very High
INFLAMMATION 56 97.68 Very High Very High Very High
Arthus Reaction 1 92.88 High High
Prostate Cancer 5 89.84 High High
Colon Cancer 8 89.04 High High
Hemorrhage 5 88.88 High High
Breast Cancer 2 88.48 High High
Neuroblastoma 2 88.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Considering that the substantia gelatinosa plays an important role in regulating nociceptive transmission, it is suggested that this transmission may be positively modulated by secreted phospholipase A2 activation in the substantia gelatinosa.
Localization (secreted) of phospholipase A2 in substantia gelatinosa associated with nociception and substantia gelatinosa
1) Confidence 0.75 Published 2005 Journal Neuroscience Section Abstract Doc Link 16111827 Disease Relevance 0.10 Pain Relevance 0.22
In order to know a role of phospholipase A2 in modulating nociceptive transmission, the effect of a secreted phospholipase A2 activator melittin on spontaneous glutamatergic excitatory transmission was investigated in substantia gelatinosa neurons of an adult rat spinal cord slice by using the whole-cell patch-clamp technique.
Localization (secreted) of phospholipase A2 in neurons associated with nociception, substantia gelatinosa neuron and spinal cord
2) Confidence 0.75 Published 2005 Journal Neuroscience Section Abstract Doc Link 16111827 Disease Relevance 0.10 Pain Relevance 0.20
We conclude that melittin increases the spontaneous release of L-glutamate to substantia gelatinosa neurons by activating secreted phospholipase A2 and increasing Ca2+ influx through voltage-gated Ca2+ channels in nerve terminals, probably with an involvement of arachidonic acid but not its metabolites produced by cyclooxygenase and lipoxygenase.
Localization (secreted) of phospholipase A2 in neurons associated with glutamate and substantia gelatinosa neuron
3) Confidence 0.75 Published 2005 Journal Neuroscience Section Abstract Doc Link 16111827 Disease Relevance 0.08 Pain Relevance 0.26
Time-course of phospholipase A2, eicosanoid release and cellular accumulation in rat immunological air pouch inflammation.
Localization (release) of phospholipase A2 associated with inflammation
4) Confidence 0.70 Published 1993 Journal Int. J. Immunopharmacol. Section Title Doc Link 8375942 Disease Relevance 0.53 Pain Relevance 0.48
(b) Extracellular fluids were separated from the macrophages and incubated with [14C]20:4-GPC: 48% of the dose was hydrolyzed by extracellular fluid-associated secreted phospholipase A2 and decyloctyl-GPC at 3 microM, reduced this hydrolysis by 50%.
Localization (secreted) of phospholipase A2 in macrophages
5) Confidence 0.53 Published 1998 Journal Fundam Clin Pharmacol Section Abstract Doc Link 9711466 Disease Relevance 0.06 Pain Relevance 0.06
In the search for candidate mediators, we examined mesenteric lymph for the presence of proinflammatory substances that are known to be produced in the gut: (a) antimicrobial peptides and antimicrobial proteins produced in the Paneth cells of the intestine (alpha-defensin 4, secretory phospholipase A2 [sPLA2], and Reg 2 protein) and (b) asymmetric dimethylarginine (ADMA), an endogenous inhibitor of NOS.
Localization (secretory) of phospholipase A2 in lymph
6) Confidence 0.34 Published 2008 Journal Shock Section Abstract Doc Link 18391861 Disease Relevance 0.22 Pain Relevance 0.15
This cascade is usually initiated by the activation of phospholipase A2 and the release of arachidonic acid (AA) [26].
Localization (release) of phospholipase A2
7) Confidence 0.25 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2315656 Disease Relevance 1.56 Pain Relevance 0.85
Systemic and intrathecal effects of a novel series of phospholipase A2 inhibitors on hyperalgesia and spinal prostaglandin E2 release.
Localization (release) of phospholipase A2 in spinal associated with hyperalgesia and intrathecal
8) Confidence 0.11 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 16203828 Disease Relevance 0.21 Pain Relevance 0.45
Based on the stimulation of AA release by known cancer chemopreventative agents, I have proposed that AA release by cells is associated with cancer chemoprevention [23-27], possibly, but not necessarily, by activating a secreted tumor suppressor phospholipase A2 (PLA2) [28,29].
Localization (secreted) of phospholipase A2 associated with cancer
9) Confidence 0.08 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC1180457 Disease Relevance 1.49 Pain Relevance 0
These prodrugs have a lipid backbone that is degradable by secretory phospholipase A2 (sPLA2) IIA.
Localization (secretory) of phospholipase A2
10) Confidence 0.07 Published 2010 Journal J Biol Eng Section Body Doc Link PMC3002303 Disease Relevance 0.38 Pain Relevance 0.09

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