INT59530

Context Info Confidence 0.49 First Reported 1993 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 1.18 Pain Relevance 0.80

extracellular region (REG1A)

Anatomy Link Frequency pancreas 2 spinal cord 2 REG1A (Homo sapiens)

Pain Link Frequency Relevance Heat Spinal cord 2 98.12 Action potential 16 97.84 anesthesia 1 95.36 depression 90 78.56 c fibre 1 77.32 Dorsal horn 4 76.32 long-term potentiation 80 49.28 primary afferent fibers 1 25.00 primary somatosensory cortex 12 5.00 Hippocampus 10 5.00

Disease Link Frequency Relevance Heat Pancreatitis 1 99.64 Stress 1 96.48 Depression 92 78.56 Sepsis 1 75.00 Li-fraumeni Syndrome 98 71.60 Pressure And Volume Under Development 2 5.00 Anaerobic Bacterial Infections 2 5.00 Nervous System Injury 2 5.00 Injury 2 5.00 Peripheral Arterial Disease 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

OBJECTIVES: The level of pancreatic stone protein/regenerating protein (PSP/reg), a secretory protein produced in the pancreas, increases dramatically during pancreatic disease.

Positive_regulation (increases) of Gene_expression (produced) of reg in pancreas associated with pancreatitis

1) Confidence 0.49 Published 2009 Journal Crit. Care Med. Section Abstract Doc Link 19325491 Disease Relevance 0.27 Pain Relevance 0.10

These results indicate that, although the generation of long-lasting "slow" PSPs by high-threshold primary afferents is necessary for the summation of synaptic activity in the spinal cord at low frequencies, the rate and pattern of the summation does not depend on the absolute duration of the PSPs.

Positive_regulation (necessary) of Gene_expression (generation) of PSPs in spinal cord associated with spinal cord

2) Confidence 0.34 Published 1993 Journal J. Neurophysiol. Section Abstract Doc Link 8389833 Disease Relevance 0 Pain Relevance 0.41

For all experiments (except when noted) PSPs were evoked by alternate stimulation of both horizontal pathways at 0.1?

Positive_regulation (experiments) of Gene_expression (evoked) of PSPs

3) Confidence 0.06 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2832108 Disease Relevance 0.45 Pain Relevance 0.15

For all experiments (except when noted) PSPs were evoked by alternate stimulation of both horizontal pathways at 0.1?

Positive_regulation (stimulation) of Gene_expression (evoked) of PSPs

4) Confidence 0.06 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2832108 Disease Relevance 0.46 Pain Relevance 0.15

General Comments

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