INT59540

Context Info Confidence 0.36 First Reported 1993 Last Reported 2009 Negated 0 Speculated 3 Reported most in Abstract Documents 2 Total Number 4 Disease Relevance 2.61 Pain Relevance 0.58

extracellular space (Crh, Gnrh1) extracellular region (Crh, Gnrh1) molecular_function (Gnrh1) response to stress (Crh) cytoplasm (Crh)

Anatomy Link Frequency MPOA 3 Crh (Rattus norvegicus) Gnrh1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Opioid 6 94.40 antagonist 16 85.28 opioid receptor 6 75.00 mu opioid receptor 3 72.36 Acupuncture 56 54.32 narcan 6 25.00 Central nervous system 2 5.00 c fibre 1 5.00 isoflurane 1 5.00

Disease Link Frequency Relevance Heat Urological Neuroanatomy 54 99.54 Polycystic Ovary Syndrome 62 91.92 Apoptosis 1 73.12 Metabolic Disorder 1 68.08 Syndrome 2 66.28 Insulin Resistance 1 65.12 Hyperinsulinism 1 64.16 Obesity 1 63.44 Anovulation 1 55.20 Hyperandrogenism 1 54.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Corticotropin-releasing hormone (CRH) may also modulate GnRH release [5] and thus may be involved in the neuroendocrine dysfunction.

CRH Spec (may) Regulation (modulate) of GnRH

1) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722078 Disease Relevance 1.25 Pain Relevance 0.05

In order to verify whether CRF is able to directly influence luteinizing hormone-releasing hormone (LHRH) secretory activity at the level of the medial preoptic area (MPOA), CRF was chronically or acutely injected bilaterally into this hypothalamic area.

CRF Spec (whether) Regulation (influence) of luteinizing hormone-releasing hormone in MPOA associated with urological neuroanatomy

2) Confidence 0.20 Published 1993 Journal Neuroendocrinology Section Abstract Doc Link 8389996 Disease Relevance 0.41 Pain Relevance 0.06

In conclusion, the present data show that from among the hypothalamic sites tested, only the MPOA proved susceptible to CRF-induced alteration of LHRH neuronal activity during proestrus afternoon in rats.

CRF Regulation (alteration) of LHRH in MPOA associated with urological neuroanatomy

3) Confidence 0.20 Published 1993 Journal Neuroendocrinology Section Abstract Doc Link 8389996 Disease Relevance 0.55 Pain Relevance 0.40

In order to verify whether CRF is able to directly influence luteinizing hormone-releasing hormone (LHRH) secretory activity at the level of the medial preoptic area (MPOA), CRF was chronically or acutely injected bilaterally into this hypothalamic area.

CRF Spec (whether) Regulation (influence) of LHRH in MPOA associated with urological neuroanatomy

4) Confidence 0.20 Published 1993 Journal Neuroendocrinology Section Abstract Doc Link 8389996 Disease Relevance 0.41 Pain Relevance 0.06

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