INT5967

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Context Info
Confidence 0.57
First Reported 1989
Last Reported 2010
Negated 0
Speculated 6
Reported most in Abstract
Documents 51
Total Number 57
Disease Relevance 27.09
Pain Relevance 18.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Il1a) extracellular space (Il1a) extracellular region (Il1a)
Anatomy Link Frequency
cartilage 3
spinal cord 1
brain 1
fibroblasts 1
PVN 1
Il1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 920 100.00 Very High Very High Very High
cytokine 451 100.00 Very High Very High Very High
agonist 219 100.00 Very High Very High Very High
dexamethasone 42 99.98 Very High Very High Very High
Antinociceptive 10 99.98 Very High Very High Very High
Intracerebroventricular 8 99.80 Very High Very High Very High
Hyperalgesia 482 99.56 Very High Very High Very High
intrathecal 43 99.42 Very High Very High Very High
cINOD 28 99.32 Very High Very High Very High
Spinal cord 39 99.26 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1035 100.00 Very High Very High Very High
Cancer 173 100.00 Very High Very High Very High
Necrosis 44 100.00 Very High Very High Very High
Urological Neuroanatomy 8 100.00 Very High Very High Very High
Targeted Disruption 48 99.98 Very High Very High Very High
Brain Injury 154 99.68 Very High Very High Very High
Hyperalgesia 490 99.56 Very High Very High Very High
Heat Stroke 114 99.40 Very High Very High Very High
Disease Progression 2 99.40 Very High Very High Very High
Nervous System Injury 36 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When compared to Naproxen, sham and extra-virgin olive oil, the levels of IL-6 and IL-1alpha were also marginally decreased in rats fed with Lyprinol.
Negative_regulation (decreased) of IL-1alpha
1) Confidence 0.57 Published 2008 Journal Eur Ann Allergy Clin Immunol Section Abstract Doc Link 19227651 Disease Relevance 0.63 Pain Relevance 0.44
Our results suggest an involvement of CRH and the noradrenergic system in the antinociceptive effect of central interleukin-1 alpha.
Negative_regulation (effect) of interleukin-1 alpha associated with antinociceptive
2) Confidence 0.42 Published 1995 Journal Brain Res. Bull. Section Abstract Doc Link 7882045 Disease Relevance 0.08 Pain Relevance 0.22
Moreover, the effect of interleukin-1 alpha is completely blocked by the intracerebroventricular administration of the corticotropin-releasing hormone antagonist alpha-helical CRH 9-41.
Negative_regulation (blocked) of interleukin-1 alpha associated with antagonist and intracerebroventricular
3) Confidence 0.42 Published 1995 Journal Brain Res. Bull. Section Abstract Doc Link 7882045 Disease Relevance 0.09 Pain Relevance 0.22
When dosed 3 hours before injury, MINO plus NAC as single drugs had no effect on interleukin-1 formation; together they synergistically lowered interleukin-1 levels.
Negative_regulation (lowered) of interleukin-1 associated with injury
4) Confidence 0.42 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2930858 Disease Relevance 0.64 Pain Relevance 0.03
Z-360, a novel therapeutic agent for pancreatic cancer, prevents up-regulation of ephrin B1 gene expression and phosphorylation of NR2B via suppression of interleukin-1 ?
Negative_regulation (suppression) of interleukin-1 associated with pancreatic cancer
5) Confidence 0.42 Published 2010 Journal Mol Pain Section Title Doc Link PMC2987997 Disease Relevance 0.96 Pain Relevance 0.78
The results suggest that this orally active inhibitor of IL-1 generation, E5090, may be a therapeutically useful antiinflammatory drug with a novel mechanism of action.
Negative_regulation (inhibitor) of IL-1 associated with inflammation
6) Confidence 0.41 Published 1991 Journal Agents Actions Suppl. Section Abstract Doc Link 2069090 Disease Relevance 1.04 Pain Relevance 0.36
E5090 is a novel orally active inhibitor of IL-1 generation without cyclooxygenase-inhibiting activity.
Negative_regulation (inhibitor) of IL-1
7) Confidence 0.41 Published 1991 Journal Agents Actions Suppl. Section Abstract Doc Link 2069090 Disease Relevance 0.71 Pain Relevance 0.15
In this study we employed postembedding electron microscopic immunocytochemistry to directly assay IL-1-induced depletion of secretory vesicles from identified VP-expressing and VP-deficient CRH neurosecretory axons.
Negative_regulation (depletion) of IL-1-induced in vesicles
8) Confidence 0.40 Published 1992 Journal Endocrinology Section Abstract Doc Link 1319322 Disease Relevance 0.07 Pain Relevance 0
APZ was shown to be a potent inhibitor of the production of leucocyte superoxide and synovial interleukin-1 (IL-1)-like activity and stimulated articular cartilage proteoglycan synthesis, but was ineffective as an inhibitor of platelet aggregation or IL-1 induced cartilage degradation in-vitro.
Negative_regulation (inhibitor) of IL-1 in cartilage
9) Confidence 0.39 Published 1989 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 2569519 Disease Relevance 0.16 Pain Relevance 0.12
RESULTS: Annulus cells, 7 days: Glucosamine completely inhibited IL-6 and TNF-alpha, increased NO (by 75%), and reduced viability (by 89%) compared with IL-1 alone.
Negative_regulation (inhibited) of IL-1 in Annulus
10) Confidence 0.37 Published 2007 Journal Spine J Section Body Doc Link 17905323 Disease Relevance 0.07 Pain Relevance 0
Given the likely role of interleukin (IL)-1 in the inflammatory (and probably the ovulatory) process, we set out to evaluate whether the antiovulatory property of NSAIDs is attributable, in part, to the inhibition of ovarian IL-1 action.
Spec (whether) Negative_regulation (inhibition) of IL-1 associated with inflammation and cinod
11) Confidence 0.36 Published 1999 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 10619394 Disease Relevance 0.26 Pain Relevance 0.51
B reduced IL-1?
Negative_regulation (reduced) of IL-1
12) Confidence 0.35 Published 2010 Journal J. Dent. Res. Section Abstract Doc Link 20647497 Disease Relevance 0.71 Pain Relevance 0.54
NAL infusion into control SAL-injected rats did not alter the LH surge; however, it reversed the IL-1 alpha- and IL-1 beta-induced suppression of the LH surge.
Negative_regulation (reversed) of IL-1
13) Confidence 0.34 Published 1990 Journal Endocrinology Section Abstract Doc Link 2226323 Disease Relevance 0 Pain Relevance 0.35
Central administration of IL-1 beta strongly increases c-Fos immunoreactivity in the PVN, mainly within CRF neurons.
Negative_regulation (administration) of IL-1 in PVN
14) Confidence 0.31 Published 1993 Journal Ciba Found. Symp. Section Abstract Doc Link 8491087 Disease Relevance 0 Pain Relevance 0.18
Intracerebroventricular (i.c.v.) administration of IL-1 alpha or IL-1 beta suppressed LH release, but IL-1 beta was relatively more effective than IL-1 alpha in terms of the onset (IL-1 beta = 30 min; IL-1 alpha = 105 min) as well as the magnitude and duration of LH suppression.
Negative_regulation (suppression) of IL-1 alpha associated with intracerebroventricular
15) Confidence 0.30 Published 1993 Journal Brain Res. Section Abstract Doc Link 8392427 Disease Relevance 0 Pain Relevance 0.16
DEX slightly inhibited IL-1-induced IL-6 release, while IL-1 releasing action on IL-6 was significantly reduced by IND.
Negative_regulation (reduced) of IL-1 associated with dexamethasone
16) Confidence 0.25 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9784426 Disease Relevance 0.07 Pain Relevance 0.32
FR133605 also inhibited serum IL-1 and TNF-alpha concentrations in LPS treated mice.
Negative_regulation (inhibited) of IL-1
17) Confidence 0.22 Published 1996 Journal J. Rheumatol. Section Body Doc Link 8895158 Disease Relevance 0.17 Pain Relevance 0
OBJECTIVE: We evaluated the effect of FR133605, a novel inhibitor of interleukin 1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha), on bone and cartilage destruction in adjuvant arthritic rats and compared it to corticosteroid, nonsteroidal antiinflammatory drugs (NSAID), and disease modifying antirheumatic drugs (DMARD).
Negative_regulation (inhibitor) of IL-1 in cartilage associated with necrosis, corticosteroid, inflammation, cancer, cinod, disease and arthritis
18) Confidence 0.22 Published 1996 Journal J. Rheumatol. Section Abstract Doc Link 8895158 Disease Relevance 0.56 Pain Relevance 0.18
We demonstrated the signal transduction pathway of IL-1 overproduction-induced cortical neuron loss during TBI.
Negative_regulation (loss) of IL-1 in neuron associated with brain injury
19) Confidence 0.22 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 16024175 Disease Relevance 0.69 Pain Relevance 0.14
Administration of ERK inhibitor, PD98059, IL-1alpha antibody and IL-1beta antibody protected animals from TBI-induced neuronal damage.
Negative_regulation (inhibitor) of IL-1alpha in neuronal associated with brain injury
20) Confidence 0.18 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 16024175 Disease Relevance 0.67 Pain Relevance 0.11

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