INT597

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Context Info
Confidence 0.62
First Reported 1975
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 26
Total Number 26
Disease Relevance 19.14
Pain Relevance 2.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PON1) extracellular region (PON1) lipid metabolic process (PON1)
Anatomy Link Frequency
liver 3
white blood cells 2
synovial fluid 1
muscle 1
proximal 1
PON1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 83 100.00 Very High Very High Very High
rheumatoid arthritis 31 100.00 Very High Very High Very High
psoriasis 6 100.00 Very High Very High Very High
imagery 3 98.22 Very High Very High Very High
qutenza 8 97.56 Very High Very High Very High
spinal inflammation 74 97.16 Very High Very High Very High
nud 1 95.32 Very High Very High Very High
abdominal pain 3 92.40 High High
withdrawal 4 88.80 High High
headache 4 83.56 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 90 100.00 Very High Very High Very High
Arthritis 74 100.00 Very High Very High Very High
Rheumatoid Arthritis 31 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 19 100.00 Very High Very High Very High
Disorders Of Creatine Metabolism 12 100.00 Very High Very High Very High
Psoriasis 6 100.00 Very High Very High Very High
Muscle Weakness 7 99.96 Very High Very High Very High
Hemolysis 1 99.96 Very High Very High Very High
Cancer 26 99.76 Very High Very High Very High
Acid Base Imbalance 1 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TAME producers showed a dose-dependent increase in TAME-esterase activity, whereas TAME nonproducers showed no change at any capsaicin dose.
Positive_regulation (increase) of TAME-esterase associated with qutenza
1) Confidence 0.62 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1762079 Disease Relevance 0.98 Pain Relevance 0.65
The main modifications are the increase of the spontaneous esterase activity and the prekallikrein lowering.
Positive_regulation (increase) of esterase
2) Confidence 0.62 Published 1976 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 1084681 Disease Relevance 0 Pain Relevance 0
mol of paraoxon substrate in 1 minute.21,22 The percent stimulation of PON1 was calculated as follows:

[(PON1 activity with 1 mol/L NaCl)-(basal activity)/basal PON1 activity] x100.23

Positive_regulation (stimulation) of PON1
3) Confidence 0.50 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2827704 Disease Relevance 0 Pain Relevance 0
Recently, a number of studies investigated serum PON and ARE activities in response to inflammatory arthritic conditions such as rheumatoid arthritis (RA), psoriasis, and systemic lupus erythematosus (SLE) with conflicting results.2,12–17 To the best of our knowledge, serum PON and ARE activities have not previously been assessed in patients with AS.
Positive_regulation (response) of PON associated with spinal inflammation, psoriasis, inflammation, rheumatoid arthritis, systemic lupus erythematosus and arthritis
4) Confidence 0.44 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2827704 Disease Relevance 1.33 Pain Relevance 0.65
Decreased PON1 activity and mild elevation in hs-CRP have drawn considerable interest, in relation to the development of atherosclerosis that exemplifies a low-grade chronic inflammatory process [37,38].
Positive_regulation (elevation) of PON1 associated with inflammation and atherosclerosis
5) Confidence 0.41 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911856 Disease Relevance 1.64 Pain Relevance 0.05
This was followed by a rise in the cholin esterase levels and the increased activity was accompanied by a rapid and definite improvement in the clinical findings.
Positive_regulation (rise) of cholin esterase
6) Confidence 0.39 Published 1976 Journal Prakt Anaesth Section Abstract Doc Link 967794 Disease Relevance 0.35 Pain Relevance 0
Peroxydase reaction stains were negative, chloroacetate esterase were strongly positive.
Positive_regulation (positive) of chloroacetate esterase
7) Confidence 0.33 Published 1975 Journal Nouv Rev Fr Hematol Section Abstract Doc Link 54900 Disease Relevance 0.35 Pain Relevance 0.09
The surviving child showed ECG and echocardiographic evidence of myocardial injury and transient elevation of the MB fraction of serum creatinine phosphokinase.
Positive_regulation (elevation) of serum creatinine phosphokinase associated with injury
8) Confidence 0.32 Published 1980 Journal JAMA Section Abstract Doc Link 7382074 Disease Relevance 1.40 Pain Relevance 0.08
Increased esterase specific activity, as measured by PNPB, in the biological media did not necessarily correlate with increased bioconversion rates of the cyclic prodrugs.
Positive_regulation (Increased) of esterase
9) Confidence 0.08 Published 2005 Journal J Pharm Sci Section Abstract Doc Link 16136552 Disease Relevance 0 Pain Relevance 0.14
Laboratory test results include neutrophil leucocytosis, thrombocytopenia, initial hemoconcentration and later anemia resulting from extravasation into the bitten limb, and rarely hemolysis, elevation of serum creatine phosphokinase, and metabolic acidosis [3].
Positive_regulation (elevation) of serum creatine phosphokinase in limb associated with anaemia, disorders of creatine metabolism, hemolysis, thrombocytopenia and acid base imbalance
10) Confidence 0.07 Published 2010 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC2949668 Disease Relevance 2.06 Pain Relevance 0.11
Thus, Alda-1 may restore the active site conformation, resulting in increased NAD binding affinity and, as a consequence, increased dehydrogenase and esterase activities.
Positive_regulation (increased) of esterase
11) Confidence 0.03 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2801295 Disease Relevance 0 Pain Relevance 0.04
Thus, limited cofactor availability may be a major cause for the low dehydrogenase and esterase activities of ALDH2*2 measured under our experimental conditions.
Positive_regulation (cause) of esterase
12) Confidence 0.03 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2801295 Disease Relevance 0 Pain Relevance 0.03
GTN bioconversion has been proposed to be catalyzed through this esterase activity of ALDH2 (4).
Positive_regulation (through) of esterase
13) Confidence 0.03 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2801295 Disease Relevance 0.16 Pain Relevance 0
(C) Multiple reports show increased enzymatic activity including esterase activity at sites of inflammation (Mørk and Bundgaard 1992; Sriram 2004).
Positive_regulation (increased) of esterase associated with inflammation
14) Confidence 0.03 Published 2008 Journal International Journal of Nanomedicine Section Body Doc Link PMC2626937 Disease Relevance 0.58 Pain Relevance 0.20
Abdominal CT and magnetic resonance imaging revealed a right primary ovarian tumor and liver metastases (Figures 1 and 2a), and her serum lactic dehydrogenase was elevated (490IU/dL).
Positive_regulation (elevated) of serum lactic dehydrogenase in liver associated with ovarian cancer, imagery and metastasis
15) Confidence 0.02 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2896377 Disease Relevance 1.00 Pain Relevance 0.14
Additionally, statin therapy has been shown to stimulate the activity of paraoxonase (PON), which has a putative role in protecting LDL from oxidation [72].
Positive_regulation (stimulate) of paraoxonase
16) Confidence 0.02 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1131912 Disease Relevance 0.34 Pain Relevance 0
Elevated esterase levels have been detected in the synovial fluid of rheumatoid arthritic patients providing a mechanism for site-specific release of ester-linked prodrugs (Kar et al 1976).
Positive_regulation (Elevated) of esterase in synovial fluid associated with arthritis
17) Confidence 0.02 Published 2008 Journal International Journal of Nanomedicine Section Body Doc Link PMC2626937 Disease Relevance 0.52 Pain Relevance 0.18
Chronic low ethanol intake stimulated paraoxonase activity by upregulating liver paraoxonase mRNA in rats and humans (Rao et al 2003).
Positive_regulation (upregulating) of paraoxonase in liver
18) Confidence 0.02 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993980 Disease Relevance 0.74 Pain Relevance 0.06
Chronic low ethanol intake stimulated paraoxonase activity by upregulating liver paraoxonase mRNA in rats and humans (Rao et al 2003).
Positive_regulation (stimulated) of paraoxonase in liver
19) Confidence 0.02 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993980 Disease Relevance 0.75 Pain Relevance 0.06
Neuroleptic malignant syndrome (NMS) is a rare side effect of antipsychotic therapy characterized by fever, muscular rigidity, altered mental status, increased level of serum creatinine phosphokinase, and increased number of white blood cells.
Positive_regulation (increased) of serum creatinine phosphokinase in white blood cells associated with neuroleptic malignant syndrome, fever and muscle rigidity
20) Confidence 0.02 Published 2005 Journal Therapeutics and Clinical Risk Management Section Abstract Doc Link PMC1661629 Disease Relevance 0.95 Pain Relevance 0.09

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