INT59718

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Context Info
Confidence 0.44
First Reported 1993
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 3.90
Pain Relevance 5.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Htr1a) plasma membrane (Htr1a) signal transducer activity (Htr1a)
Anatomy Link Frequency
trigeminal ganglion 1
synaptic cleft 1
DRN 1
brain 1
Htr1a (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 151 100.00 Very High Very High Very High
Migraine 1 100.00 Very High Very High Very High
agonist 21 99.96 Very High Very High Very High
fluoxetine 30 99.78 Very High Very High Very High
Sumatriptan 6 99.60 Very High Very High Very High
corticosteroid 8 99.48 Very High Very High Very High
trigeminal ganglion 5 97.28 Very High Very High Very High
adenocard 2 95.72 Very High Very High Very High
antagonist 75 94.80 High High
antidepressant 95 93.68 High High
Disease Link Frequency Relevance Heat
Headache 5 100.00 Very High Very High Very High
Anxiety Disorder 82 99.08 Very High Very High Very High
Sprains And Strains 3 99.08 Very High Very High Very High
Ganglion Cysts 5 96.84 Very High Very High Very High
Catalepsy 6 96.64 Very High Very High Very High
Stress 21 96.00 Very High Very High Very High
Skin Diseases 2 93.28 High High
Pressure And Volume Under Development 2 92.80 High High
Eczema 18 87.52 High High
Depression 28 85.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several lines of evidence indicate the crucial role of both 5HT1A and 5HT2A receptors in the regulation of serotonergic neurotransmission and the involvement of these receptors in the mechanism of action of many classes of antidepressant drugs, including SSRI, MAOI, and tricyclics (Hensler 2002; Middlemiss et al. 2002).
Regulation (role) of 5HT1A associated with antidepressant and ssri
1) Confidence 0.44 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2981731 Disease Relevance 0 Pain Relevance 0.69
These experiments demonstrate that, under basal and KCl stimulated conditions, adaptive mechanisms in the 5-HT system compensate for the lack of 5-HT1A autoreceptor regulation of DRN.
Regulation (regulation) of 5-HT1A in DRN
2) Confidence 0.44 Published 2001 Journal Brain Res. Section Abstract Doc Link 11376590 Disease Relevance 0.21 Pain Relevance 0.36
Differential effects of 5-HT1A receptor deletion upon basal and fluoxetine-evoked 5-HT concentrations as revealed by in vivo microdialysis.
Regulation (effects) of 5-HT1A associated with fluoxetine
3) Confidence 0.44 Published 2001 Journal Brain Res. Section Title Doc Link 11376590 Disease Relevance 0.24 Pain Relevance 0.36
Fluoxetine failed to alter 5-HT1A receptor functional activity in mice of both strains and diminished 5-HT2A receptor functional activity in CBA but not in ASC mice.
Neg (failed) Regulation (alter) of 5-HT1A associated with sprains and strains and fluoxetine
4) Confidence 0.26 Published 2009 Journal Zh Vyssh Nerv Deiat Im I P Pavlova Section Abstract Doc Link 19445393 Disease Relevance 0.79 Pain Relevance 0.55
Hypo-responsiveness of the 5-HT1A receptor is linked to anxiety and constitutive deletion of the 5-HT1A receptor produces anxiety-like behaviors in the mouse.
Regulation (responsiveness) of 5-HT1A associated with anxiety disorder
5) Confidence 0.26 Published 2001 Journal Brain Res. Section Abstract Doc Link 11376590 Disease Relevance 0.25 Pain Relevance 0.26
Furthermore, it has been suggested that this modulation of postsynatptic 5-HT1A function by corticosteroids can be mediated at the level of G protein coupling (Okuhara and Beck 1998).
Regulation (modulation) of 5-HT1A associated with corticosteroid
6) Confidence 0.26 Published 2010 Journal J Neurodev Disord Section Body Doc Link PMC2882561 Disease Relevance 0.37 Pain Relevance 0.23
We also investigated the expression of genes that may affect 5-HT1A receptor function and correlated the localization of GTF2IRD1 protein with the neurophysiological difference found in the Gtf2ird1?
Regulation (hat ma) of 5-HT1A
7) Confidence 0.26 Published 2010 Journal J Neurodev Disord Section Body Doc Link PMC2882561 Disease Relevance 0.71 Pain Relevance 0.07
Fluoxetine increases extracellular serotonin in the brain. 5HT1A autoreceptors regulate synaptic levels of serotonin.
Regulation (regulate) of 5HT1A in brain associated with serotonin and fluoxetine
8) Confidence 0.16 Published 1998 Journal Brain Res. Section Abstract Doc Link 9507085 Disease Relevance 0 Pain Relevance 1.07
Serotonin generally exerts its effects through seven families of receptors.15 Of these subtypes, the 5HT1A and 5HT2A receptors have been suggested to have opposing functions in a variety of cellular and behavioural processes.16 The serotonin transporter protein (SERT) regulates 5-HT concentrations in the synaptic cleft via recycling released serotonin, thus terminating the action of 5-HT, and is a target for serotonin reuptake inhibitors.
Regulation (target) of 5HT1A in synaptic cleft associated with serotonin
9) Confidence 0.12 Published 2008 Journal Journal of the European Academy of Dermatology and Venereology Section Body Doc Link PMC2229631 Disease Relevance 0.94 Pain Relevance 0.81
The aim of this study was to investigate the effect of the anti-migraine drug and selective 5-HT1 receptor agonist, sumatriptan, on membrane potential of guinea-pig isolated trigeminal ganglion.
Spec (investigate) Regulation (effect) of 5-HT1 receptor in trigeminal ganglion associated with ganglion cysts, sumatriptan, trigeminal ganglion, migraine and agonist
10) Confidence 0.07 Published 1993 Journal Cephalalgia Section Abstract Doc Link 8395343 Disease Relevance 0.33 Pain Relevance 0.53
Additionally, the reinstatement of 5HT1A auto-regulation decreases serotonin concentrations by allowing negative feedback inhibition of serotonin production and release.
Regulation (regulation) of 5HT1A associated with serotonin
11) Confidence 0.01 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 0.06 Pain Relevance 0.51

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